Results 21 to 30 of about 98,699 (173)
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
The transcriptional coactivator TAZ regulates reciprocal differentiation of T(h)17 cells and T(reg) cells [PDF]
, 2017 自身免疫性疾病是一类机体对自身抗原发生免疫反应而导致自身多器官、组织受累的慢性炎症性疾病。目前大量研究表明机体内促炎症的TH17细胞和抑制炎症Treg细胞在类群数量和活化状态的失衡是造成自身免疫疾病的主要致病因素。陈兰芬教授和周大旺教授团队的前期研究发现小鼠中Hippo信号通路中激酶Mst1/2缺失导致免疫缺陷，机体易受病原体感染并伴随着严重自身免疫疾病。该研究揭示了Hippo 信号通路转录共激活因子TAZ在决定CD4 ...
Changchuan Xie +19 more
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Review of Policy Research, Volume 43, Issue 2, March 2026.ABSTRACT This study adapts the Multiple Streams Framework (MSF) to explore why COVID‐19 vaccine mandates were applied at sectoral and subnational levels in Vietnam while the central government maintained that vaccination was voluntary. Document analysis reveals that these mandates arose from the effective coupling of the three streams—problem, policy ...
Hang Duong, Katie Attwell
wiley +1 more source
Huli yanjiu, 1989 一、名词解释微生物、质粒、芽胞、鞭毛、荚膜、热原质、菌落、条件致病菌、正常菌群、菌群失调、灭菌、无菌、防腐、消毒、噬菌体、外毒素、内毒素、类毒素、传染、败血症、毒血症、菌血症、脓毒血症、培养基、免疫、免疫监视、抗原、半抗原、不完全抗原、抗原决定簇、自身抗原、异嗜性抗原、佐剂、补体、抗体、免疫球蛋白、免疫活性细胞、免疫应答、体液免疫、细胞免疫、免疫耐受、免疫系统、特异性免疫、变念反应、Arthus现象、人工自动免疫 ...
寇全根
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Haiyang yu huzhao为探究山莨菪碱在浸泡免疫大黄鱼中的应用效果，以添加山莨菪碱佐剂的杀香鱼假单胞菌灭活疫苗浸泡免疫大黄鱼，结果显示，免疫后1~4周，无佐剂疫苗组(FKC组)和山莨菪碱疫苗组(FKCA组)血清抗体水平均显著升高，第2~3周FKCA组血清抗体显著高于FKC组。rt-PCR结果显示，从免疫后第4天开始，头肾、脾脏中免疫因子IgM、IL-1β、MHC-Iα、MHC-IIβ、CD4、CD8的表达量均出现升高，FKCA组头肾中IgM、IL-1β、MHC-Iα、CD8的表达峰值显著高于FKC组。酶活结果显示 ...
李 姣姣 +6 more
doaj +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 自然杀伤（NK）细胞是T细胞后具有临床应用前景的另一类抗肿瘤免疫细胞。NK 细胞的活性主要受其表面受体和免疫微环境的调控，胶质瘤较强的免疫抑制性肿瘤微环境使NK细胞免疫治疗效率较低。本综述从胶质瘤-NK细胞交互作用角度讨论NK细胞在脑胶质瘤免疫治疗中作用的最新研究进展，总结靶向NK 细胞的化合物、单克隆抗体和细胞因子疗法，重点讨论了基因修饰的NK细胞在胶质瘤免疫治疗的现状及趋势，以及胶质瘤细胞的相关免疫逃逸分子机制，为基于NK细胞的免疫治疗神经胶质瘤提供理论依据和新的思路。
孙士隆, 陈保东
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Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
野生动物学报, 2012 多年来动物园虽然严格按照国家强制要求对园内饲养的野生鸟类进行禽流感疫苗的免疫接种工作,但是对于接种后各种鸟类免疫效果的问题仍未有研究。本次研究主要目的为探究圈养鸟类免疫商品化禽流感疫苗后的免疫效果如何,以及各个物种对疫苗的免疫应答水平是否相同。实验中选取动物园几种圈养小型鹦鹉科鸟类为实验对象,对其进行禽流感H5N1亚型疫苗免疫接种后,利用血凝（HA）及血凝抑制（HI）实验监测禽流感抗体水平变化规律,评估免疫效果。从初步的实验结果发现,鹦鹉科鸟类仅接种一次商品化禽流感疫苗,其免疫应答水平普遍偏低 ...
李莹, 吴秀山, 张成林, 张金国
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