[An improved 4-vessel intermittent occlusion method for establishing rat models of global cerebral ischemia-reperfusion injury]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Sun W, Chen P, Tang X, Gu Y, Tian X.
europepmc +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨程序性坏死是否参与肠缺血再灌注所致肺损伤的发病机制。【方法】雄性SD大鼠32只，随机分 为4组（n = 8）：假手术组（sham组）、肠缺血再灌注组（I/R组）、程序性坏死特异性抑制剂Necrostatin?1组（Nec-1组）和溶剂二 甲基亚砜组（DMSO组）。采用夹闭肠系膜上动脉1.5 h再灌注6 h的方法制备肠缺血再灌注损伤模型。sham组仅分离血管； Nec-1组及DMSO组分别于夹闭肠系膜上动脉前30 min时腹腔注射Necrostatin?11.0 mg ...
温仕宏, 刘克玄
doaj
Sevoflurane preconditioning alleviates myocardial ischemia reperfusion injury through mitochondrial NAD+-SIRT3 pathway in rats. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Qin X +6 more
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Study on the action mechanism of lncRNA MIAT/miR-384-5p in rats with acute myocardial infarction [PDF]
Objective To investigate the role and molecular mechanism of lncRNA MIAT inhibition in acute myocardial infarction (AMI) in rats. Methods Sixty male Sprague-Dawley (SD) rats were randomly divided into sham, AMI, AMI+si-NC, AMI+si-MIAT, AMI+si-MIAT+miR-NC
CHEN Huibin, JIAN Jie, LI Can
core +1 more source
移植沉默ＴＳＧ－６基因的骨髓间充质干细胞对大鼠肝脏缺血再灌注损伤的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要： 【目的】 在大鼠肝脏缺血再灌注模型中，观察移植沉默ＴＳＧ－６基因的骨髓间充质干细胞（ＢＭＳＣ）对大鼠肝脏缺血再灌注损伤（ＨＩＲＩ）的影响。 【方法】 全骨髓培养法分离培养大鼠骨髓间充质干细胞，流式细胞学鉴定，慢病毒载体（ＬＶ３－ ｓｈＴＳＧ－６）感染下调ＴＳＧ－６基因的表达；６０只ＳＤ雌性大鼠７０％肝脏缺血再灌注损伤模型的建立，随机分４组，ＰＢＳ组、ＢＭＳＣ组，ｓｈＲＮＡ－ＮＣ－ＢＭＳＣ组、ＴＳＧ－６－ｓｈＲＮＡ－ＢＭＳＣ组；各组大鼠分别于恢复灌注后３、６、２４ ｈ取血检测血清中ＡＬＴ、ＡＳＴ、
doaj
[Soybean isoflavones alleviate cerebral ischemia/reperfusion injury in rats by inhibiting ferroptosis and inflammatory cascade reaction]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Li S +9 more
europepmc +1 more source
98例肝移植患者术后肝穿刺活检标本组织病理学分析 [PDF]
, 2007 【目的】对98例肝移植（OLTx）患者术后肝穿刺活检病理资料进行回顾性分析，探讨OLTx术后各种并发症的组织形态学表现，提高移植病理诊断水平。【方法】收集361例OLTx患者病例资料，其中98例OLTx患者术后因肝功能异常行肝穿刺活检，常规HE染色以及HBsAg、HBc、HCV、CMV免疫组化染色。部分病例行CK19免疫组化染色。【结果】98例患者共行肝穿刺129次，结果急性排斥反应最常见，共计42例（42．86％），其余为慢性排斥反应2例（2．04％），缺血一再灌注损伤8例（8．16 ...
冯智英, 周静, 邵春奎
core
Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols [PDF]
Reactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide.
Jinchan PI +5 more
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Zhongguo shiyan zhenduanxue, 2013 脑血管病是临床常见病、多发病,其发病率、病死率及致残率逐年上升[1]。其中缺血性脑血管病尤其脑缺血后的再灌注损伤,危害极大。因此中药对中枢神经系统保护作用的研究越来越受到重视,寻找新型有效药物是目前研究的热点 ...
张艳 +4 more
doaj
[Maresin1 inhibits the NF-κB/caspase-3/GSDME signaling pathway to alleviate hepatic ischemia-reperfusion injury]. [PDF]
Zhonghua Gan Zang Bing Za Zhi, 2023 Zeng HS, Wang YB, Chen LXZ, Zhu P.
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