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临床医学与护理乳腺癌是全球女性中最常见的恶性肿瘤之一，化疗是治疗乳腺癌的重要手段。然而，化疗的疗效存在显著个体差异，近年来的研究表明，基因多态性可能在化疗效果中起到了关键作用。本论文旨在探讨基因多态性对乳腺癌化疗效果的影响，重点分析与药物代谢、药物靶标和DNA修复相关的基因变异如何影响患者对化疗药物的反应。通过对现有文献的回顾，结合临床研究数据，评估不同基因多态性对乳腺癌化疗效果的具体作用。最终，文中将为个体化治疗策略提供理论依据，推动乳腺癌的精准医学发展。
文睿 熊
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Association of MTHFR C677T polymorphism with male infertile in Xiamen area [PDF]
, 2017 目的探讨亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与男性不育的相关性。方法选取少、弱精症患者66例和无精症患者74例为实验组,精液正常且有正常孕育史的男性96例为对照组,分析MTHFR C677T基因多态性在三组中分布的差异。结果与对照组相比,少、弱精组中MTHFR C677T各基因型的频率差异没有显著性意义（P〉0.05）;与对照组相比,无精组中MTHFR C677T各基因型的频率差异没有显著性意义（P〉0.05）。结论在少、弱精症患者、无精症患者和健康人中,基因多态性分布无显著差异 ...
王厚照, 谭振军, 马芳芳
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陕西人群中IL-8、IL-10单核苷酸基因多态性与结直肠癌的易感性
, 2015 目的：探讨陕西人群中白介素-8（interleukin-8,IL-8）-251A/T、IL-10-1082A/G单核苷酸基因多态性（single nucleotide polymorphism,SNP）与结直肠癌的遗传易感性.方法：采用病例对照研究的方法,应用等位特异性聚合酶链式反应（allele specific polymerase chain reaction,AS-PCR）,分别检测102例结直肠癌患者和105例健康对照人群中IL-8-251A/T、IL-10-1082A/G的基因分布 ...
李红霞 +4 more
semanticscholar +1 more source
Research Progress on the Relationship between Genetic Polymorphism and Violent Behavior of Patients with Schizophrenia [PDF]
, 2020 Schizophrenia is a common disease characterized by thinking obstructions and accompanied by cognitive, emotional and behavioral disorders. Under the control of psychiatric symptoms, patients with schizophrenia may self-injure or impulsively wound others,
XU Shuo, LIANG Yi-ying, HONG Bin-xue,et al
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The effect of PNPLA3 ploymorphism in the intervention of non-alcoholic fatty liver disease [PDF]
, 2015 研究目的 运动是治疗非酒精性脂肪性肝疾病的一个重要方法，而脂肪滋养蛋白基因（PNPLA3）是非酒精性脂肪性肝疾病的一个重要的基因遗传因子。本研究的目的是为了探讨脂肪滋养蛋白基因的多态性表达是否影响到运动干预非酒精性脂肪性肝疾病的过程。 研究方法 本研究共招募40-65岁中心性肥胖受试者1059人，进行常规体检，并运用彩超检测脂肪肝。并随机抽取476名肥胖受试者进行1H-MRS对其肝内甘油三酯进行定量测定。在这476名肥胖受试者中，随机抽取220人分为三组，强化运动组（先进行6个月的强化运动期 ...
黄竹锋
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Integrative Conservation, EarlyView.Accurate species identification is critical for conserving endangered Firmiana trees in China. However, morphological similarities among closely related Firmiana species complicate its taxonomic identification. We conducted genome skimming on 62 samples representing all 10 Chinese species and discovered nrITS as the optimal DNA barcode, achieving 100 ...
Li‐Jun Yan +8 more
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Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Cisplatin-based Chemotherapy [PDF]
, 2010 Background and objective Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting.
Hui ZHANG +6 more
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Integrative Conservation, EarlyView.Key Largo woodrats are a small and endangered island species, whose individuals tend to occur in family groups. Isolation from mainland populations, predation, and habitat fragmentation have caused genetic drift, leading to low overall diversity. Here, we found that a major category 4 hurricane promoted genetic diversity in the Key Largo woodrat ...
Taylor Ackley +5 more
wiley +1 more source
Justice in coexistence: Pastoralism and large carnivores on the Qinghai‐Tibet Plateau
People and Nature, EarlyView.Abstract The conflict between livestock husbandry and large carnivore conservation presents significant challenges in grassland ecosystems worldwide. Achieving sustainable coexistence among herders, livestock and large carnivores requires reconciling diverse perspectives and interests through equitable, inclusive and fair processes that address both ...
Yufang Gao, Yue Yu
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Investigation of the association between adult intelligence and Apolipoprotein E genotype in the young Chinese Han population [PDF]
, 2015 载脂蛋白E（ApolipoproteinE）在脂质代谢及分布中具有重要作用。载脂蛋白E基因具有多态性，包含了APOEɛ2、APOEɛ3和APOEɛ4三种。其中，ɛ4等位基因是引起迟发型阿尔茨海默病（Late-onsetAlzheimer’sDisease）最重要的危险因素。尽管许多研究表明在老年人中APOE基因的多态性与认知功能密切相关，但其对青年人认知功能的影响研究非常少，并且有限的研究结果存在争议性。为了进一步探讨APOE基因多态性对青年人认知功能的影响 ...
魏孜辰
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