Results 21 to 30 of about 25,254 (214)
Investigation of the association between adult intelligence and Apolipoprotein E genotype in the young Chinese Han population [PDF]
, 2015 载脂蛋白E（ApolipoproteinE）在脂质代谢及分布中具有重要作用。载脂蛋白E基因具有多态性，包含了APOEɛ2、APOEɛ3和APOEɛ4三种。其中，ɛ4等位基因是引起迟发型阿尔茨海默病（Late-onsetAlzheimer’sDisease）最重要的危险因素。尽管许多研究表明在老年人中APOE基因的多态性与认知功能密切相关，但其对青年人认知功能的影响研究非常少，并且有限的研究结果存在争议性。为了进一步探讨APOE基因多态性对青年人认知功能的影响 ...
魏孜辰
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Representation of obligate groundwater‐dwelling copepod diversity in European protected areas
Conservation Biology, EarlyView.Abstract Groundwaters sustain diverse surface ecosystems and are populated by metazoan species, mostly invertebrates, that provide fundamental ecological functions and are often of prominent conservation value due to narrow endemism and high phylogenetic rarity.
Francesco Cerasoli +7 more
wiley +1 more source
The association study between the polymorphisms in P53 and MDM2 and the genetic susceptibility of primary hepatocellular carcinoma among Xiamen population [PDF]
, 2015 目的 探讨厦门市P53基因rs1042522位点、MDM2基因rs2279744位点的单核苷酸多态性（SNP）与原发性肝细胞癌（HCC）遗传易感性的关系，为筛检肝癌高危人群，以及进行肝癌一、二级预防提供参考依据。 方法 采用病例-对照研究设计，抽样调查在2011年1月至2014年10月间厦门市综合性三甲医院就诊的肝癌患者和健康对照者。病例组纳入标准：根据HCC诊断依据在调查期间被首次确诊为HCC、年龄≥18岁、现住址与调查地属同一区（县）级范围、无任何其他肿瘤史的患者。排除标准：患有HCC以外的肿瘤 ...
潘欢欢
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Conservation Biology, EarlyView.Abstract Despite the crucial role of human impacts on biodiversity loss, many assessments of this loss focus on single metrics, such as species richness, and overlook the multidimensional effects of human activities. Because of its importance to ecosystem functioning, we investigated the functional diversity of medium‐ and large‐sized mammal ...
Xueyou Li +8 more
wiley +1 more source
AKT1基因多态性与中国汉族人群双相情感障碍遗传易感性的关系探讨
Zhongguo shiyan zhenduanxue, 2021 目的探讨蛋白激酶B1(AKT1)基因多态性与中国汉族人群双相情感障碍(BPD)遗传易感性的关系。方法选取2018年10月-2020年10月阜阳市第三人民医院收治的110例BPD患者,设为BPD组;另选取同期进行体检的110例健康受试者,设为健康组。采用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)分析外周血AKT1基因位点rs2494732、rs3001371、rs3803300、rs2498799、rs3730358单核苷酸多态性(SNP),比较BPD组与健康组位点基因型分布及等位基因频率 ...
闻庆云, 周香云, 吴远雄
doaj
Geographic risks to functional groups of mammals and birds from habitat loss in Mexico
Conservation Biology, EarlyView.Abstract There is a need to quantify the impact of habitat loss due to anthropogenic factors on different aspects of biodiversity, such as functional trait diversity represented by functional groups (FGs). We developed a metric to assess the weighted risk of loss of habitat for 33 FGs of mammals and 36 FGs of birds in Mexico based on potential ...
Fernando Mayani‐Parás +4 more
wiley +1 more source
Association of the polymorphis ms in STIM1 / ORAI1 / TRPC1 genes with the risk of calcium u rolithiasis [PDF]
, 2015 目的：寻找基质相互作用因子1（Stromalinteractionmolecule1，STIM1）、钙释放激活钙通道调节分子1（Calciumrelease-activatedcalciummodulator1，ORAI1）和瞬时受体电位阳离子通道1（Transientreceptorpotentialcationchannel1，TRPC1）基因中与泌尿系含钙结石发病有关的易感位点及可能存在的单体型，探讨这三者基因多态性与泌尿系含钙结石发病的关联性。 方法：1、采用病例-对照研究策略 ...
林敬莱
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Biodiversity‐driven spatial conservation planning to delineate temporally stable regions
Conservation Biology, EarlyView.Abstract The accelerating loss of biodiversity underscores the critical need for effective conservation strategies, particularly in the face of climate change and anthropogenic pressures. We devised a conservation planning framework that adopts a temporal stacking approach to species distribution models and landscape connectivity analyses. These models
Mattia Iannella +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2003 目的 探讨儿童持续性蛋白尿与血管紧张素转换酶基因多态性的关系。方法 用PCR方法检测了 186例儿童持续性蛋白尿患儿ACE基因多态性及ACE基因多态性与尿蛋白量、血尿、高血压、氮脂血症的关系。结果 持续性蛋白尿患儿ACE -DD基因频率为 0 .2 0 ,II基因频率为 0 .5 2 ,DI基因频率为 0 .2 8;持续性蛋白尿患儿ACE基因多态性与正常对照组存在明显差异 ;尿蛋白量与ACE基因多态性有关 ,大量蛋白尿多为ACE -II型 ;在紫癜性肾炎组血尿的发生以II型为主 ...
李丽红 +16 more
doaj
Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis [PDF]
, 2014 Objective: Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent.
Lei-zhi Shi, Xiao Wang
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