Results 61 to 70 of about 20,056 (169)

Conservation Status, Decline Factors, and Strategies for Globally Endangered Musk Deer (Moschus spp.) in China 中国境内全球濒危麝属 (Moschus spp.) 物种的保护现状、致危因素及应对策略

open access: yesWildlife Letters, Volume 4, Issue 1, Page 42-55, March 2026.
This review summarizes the status of musk deer in China, highlighting severe population declines due to illegal hunting and habitat loss, and proposes integrated conservation strategies including habitat protection, captive breeding, and law enforcement to support the recovery and sustainable management of this ecologically and economically important ...
Feng Jiang   +8 more
wiley   +1 more source

血管紧张素原基因M235T多态性与结直肠癌易感性关系的研究

open access: yesZhongguo shiyan zhenduanxue, 2012
目的探讨血管紧张素原(AGT)基因M235T多态性与中国人群结直肠癌易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法检测结直肠癌组151例患者和健康对照组202例AGT基因M235T多态性。结果结直肠癌组与对照组AGT20M235T基因型和等位基因分布差异无统计学意义(P>0.05)。根据临床病理特征进行分层分析,发现携带TT基因型个体患低分化结直肠癌的风险比携带MT/MM基因型高2.50倍(P=0.008,OR=2.50;95%CI,1.26-4.97 ...
侯波
doaj  

MDR1基因多态性与肝癌易感性的关系 [PDF]

open access: yes, 2009
目的:探讨MDR1基因位点单核苷酸多态性与肝癌易感性的关系。方法:采用病例对照研究,应用聚合酶链反应限制性片段长度多态性(PCR-RFLP)基因型分析技术测定原发性肝癌组及正常健康对照组各100例MDR1基因G2677T/A位点。以χ2检验比较MDR1多态基因型及相关危险在病例与对照之间分布的差异,采用非条件Logistic回归分析多态基因型与肝癌发生危险度的关系。结果:肝癌组MDR1基因2677A携带型低于健康对照组 ...
冯水土, 张永兴, 杨芳, 陈毅德
core  

Landscape Composition and Proximity to Water Affect American Badger Occupancy in Shortgrass Prairies 景观组成和与水的距离影响矮草草原中美洲獾的占域率

open access: yesWildlife Letters, Volume 4, Issue 1, Page 23-31, March 2026.
American badgers, a medium‐sized carnivore occurring in much of North America, are important predators in prairie landscapes though our understanding of their habitat use requirements in these areas is unclear. We used a multi‐scale approach to understand American badger habitat use at both local and landscape scales.
Colleen W. Piper   +5 more
wiley   +1 more source

TaqMan-MGB法检测ACTN3基因R577X多态性

open access: yesZhongguo shiyan zhenduanxue, 2017
目的研制检测ACTN3基因R577X多态性的TaqMan-MGB探针方法。方法根据美国国立医学图书馆网站公布的人类ACTN3基因序列(rs1815739),设计检测ACTN3基因R577X多态性的特异引物和TaqMan-MGB探针,建立和优化实验条件。结果对98例西北大学汉族学生进行ACTN3基因R577X多态性检测,并对上述所有检测标本再进行碱基序列测序,两种检测方法的检测结果经Kappa分析,Kappa=0.99。结论两种检测方法结果一致性较好,建立了检测ACTN3基因R577X多态性的TaqMan-
张志明, 高鹏华, 胡辽辽, 马莹
doaj  

Effects of ApoE Isoforms Expression on Brain ApoE Lipidation and Amyloid-β Accumulation [PDF]

open access: yes, 2015
在编码人三种不同apoE蛋白亚型(E2、E3和E4)的APOE等位基因(ε2、ε3和ε4)中,APOEε4等位基因是阿尔茨海默病(Alzheimer’sdisease,AD)最重要的遗传风险因子,APOEε2等位基因则具有保护作用。鉴于apoE蛋白亚型对基于调节apoE蛋白表达的AD治疗可能会有不同的影响,我们通过在人APOE基因定位替换(Targetedreplacement,TR)小鼠脑中过表达不同的人apoE亚型,研究脑中表达不同apoE亚型对apoE脂化和β-淀粉样蛋白(Amyloid-β,Aβ)
胡进
core  

A Tale of Two Programs? Stigma and Administrative Burdens in CHIP and Medicaid

open access: yesWorld Medical &Health Policy, Volume 18, Issue 1, March 2026.
ABSTRACT One contributing factor to undersubscriptions is administrative burdens. To explore whether program stigma affects attitudes about administrative burdens, a survey (N = 2204) was fielded to assess differences in attitudes about seven policies decreasing administrative burdens and two policies increasing administrative burdens.
Simon F. Haeder
wiley   +1 more source

吉林地区汉族人群脂联素基因多态性与冠心病的相关性

open access: yesZhongguo shiyan zhenduanxue, 2006
目的探讨吉林地区汉族人群脂联素基因(apM1)多态性与与冠心病的关系。方法运用单核苷酸多态性分析技术在251例无亲缘关系的吉林地区汉族人群(正常对照人群131例,冠心病120例)中检测apM1基因2号外显子及3号外显子的多态性。结果吉林地区汉族人群中SNP45(T/G)和SNP331(T/C)多态性的基因型频率和等位基因频率在冠心病组和正常对照组间的分布存在显著性差异 ...
王楠, 李淑梅
doaj  

The coordination of dehydration tolerance and avoidance in oaks is mediated by leaf habit across a precipitation gradient

open access: yesFunctional Ecology, Volume 40, Issue 3, Page 750-763, March 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Forests worldwide are increasingly impacted by drought due to climate change, prompting plants to adapt through dehydration tolerance (DT) and avoidance (DA), two distinct physiological strategies.
Xingyun Liang   +11 more
wiley   +1 more source

转化生长因子β1基因多态性与食管癌的关系

open access: yesZhongguo shiyan zhenduanxue, 2010
目的研究转化生长因子β1(TGF-β1)基因启动子区-800G/A和第1外显子+915G/C基因多态性各等位基因及基因型在食管癌患者中的分布频率,初步分析其基因型及血清水平与食管癌的相关性。方法采用序列特异性引物聚合酶链反应(PCR-SSP)和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测118例食管癌患者和130例正常对照组TGF-β1的基因多态性,包括TGF-β1基因启动子-800G/A、第1外显子+915G/C位点,同时采用酶联免疫吸附试验(ELISA)检测血清TGF-β1水平 ...
唐任光   +5 more
doaj  

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