Results 1 to 10 of about 4,978 (145)
基质金属蛋白酶在口腔黏膜癌变过程中的表达及临床意义 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 摘 要:【目的】观察基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶抑制因子-2(TIMP-2) 在口腔黏膜白斑及其癌变组织中的表达, 推断MMP 在白斑癌变过程中的作用。【方法】通过免疫组织化学的方法检测22 例 白斑, 7 例白斑癌变组织以及14 例正常黏膜组织中MMP-2、MMP-9 及TIM P-2 表达的情况。【结果】白斑癌变组的MMP-2 、 MM P-9 表达阳性率分别为85.7 %、100 %, 均高于正常组(P 0.05), MMP-9 ...
蔡华雄, 潘朝斌
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辛伐他汀含药血清对U937单核巨噬细胞MMP-9及TIMP-1表达与分泌的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】探讨辛伐他汀含药血清对U937单核细胞源巨噬细胞基质金属蛋白酶-9（MMP-9）及金属蛋白酶组织抑制因子-1（TIMP-1）表达与分泌的影响。【方法】15只新西兰大白兔随机分为正常对照组（NL,n=5）、粥样硬化模型组（AS,n=5）和辛伐他汀含药血清组（SIM,n=5）。通过喂养高脂饲料,建立兔动脉粥样硬化模型后,予辛伐他汀药液灌胃,获得含药血清。分别予不同浓度含药血清（5%、10%、20%）培养U937单核细胞源巨噬细胞24 h,应用逆转录聚合酶链反应检测MMP-9 mRNA及TIMP-1 ...
刘金来, 朱强锋, 郝宝顺
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TK-1 和 TIMP-1 过表达对大鼠心肌梗死后心室重塑的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】探讨重组腺病毒介导的人TK-1和TIMP-1基因过表达对大鼠心肌梗死后的左室（LV）功能、炎症因子表达的影响及其机制。【方法】通过结扎Sprague-Dawley雄性大鼠冠脉左前降支诱导心肌梗死模型。观察假手术组（10只）、生理盐水组（13只）、对照病毒组（13只）、TK-1组（13只）、TIMP-1组（13只）、联合基因组（13只）的大鼠术后的心功能参数改变、心肌梗死面积、及各组大鼠基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）、核因子-κB（NF-κB ...
郑熙, 余惠珍, 高洁, 朱鹏立
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A case report of heat stroke with early severe brain edema [PDF]
, 2023 Heat stroke can be divided into two types: exertional and classic, mainly manifested as a clear history of exposure to hot temperature/high heat environment or intense physical activity in hot environment, core temperature exceeding 40 ℃, accompanied by ...
Liya PAN, Shisheng LUO, Tuoying WEN
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Physiological function of nerve injury-induced protein 1 and its role in relevant diseases [PDF]
, 2023 Nerve injury-induced protein 1 (NINJ1) is a cell-surface adhesion molecule containing an extracellular adhesion domain and two transmembrane domains. NINJ1 is named for its original discovery in damaged nerve endings.
LU Xinwu +4 more
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, 2017 中枢神经系统（CNS）由大量的神经细胞组成,星形胶质细胞是其中分布最广的一类神经胶质细胞,具有营养支持、调节神经递质及影响突触功能等多种生理功能。星形胶质细胞高表达基因-1（AEG-1）是一种原癌基因,对多种CNS肿瘤细胞的增殖、发展及转移有重要影响。本文从AEG-1对CNS肿瘤的诊断、治疗和预后评估方面的作用进行综述 ...
叶翔, 吴小艳, 许奇平, 邢惠琴
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Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis [PDF]
, 2014 Objective: Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent.
Lei-zhi Shi, Xiao Wang
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Significance of alpha-fetoprotein combined with apolipoprotein A1 and alkaline phosphatase in the diagnosis of hepatitis B virus-related liver cancer [PDF]
, 2023 Objective To investigate the changes of apolipoprotein A1 （ApoA1） and alkaline phosphatase in hepatitis B virus （HBV）-related liver cancer， and evaluate the diagnostic performance of alpha-fetoprotein （AFP） combined with other indexes for HBV-related ...
Li Mei, Liu Minsi, Huang Yuehua, Xu Yingjun
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Correlation analysis of Egr3， IL-6， TNF-α and the severity of coronary heart disease [PDF]
, 2023 Objective To investigate the correlation between early growth response factor 3（Egr3）， pro-inflammatory cytokines IL-6 and TNF-α and coronary atherosclerotic heart disease （CHD）.
Wang Siqing, Zumureti·Abudukeyimu, Li Xia
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Clinical analysis of insulin resistance in liver cirrhosis patients [PDF]
, 2023 Objective·To investigate the insulin resistance in liver cirrhosis patients.Methods·Patients with liver cirrhosis from Xinhua Hospital,Shanghai Jiao Tong University School of Medicine in 2013‒2017 were retrospectively assessed.
HUANG Heming +4 more
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