Invasion and Metastasis Significance of Serum MMP-9 in Lung Cancer Patients [PDF]
目的 研究基质金属蛋白酶-9(matrix metalloproteinase 9，MMP-9)在肺癌患者侵袭和转移的意义。方法 收集肺癌患者血清70例，健康体检者血清60例，通过酶联免疫吸附法(ELISA)检测鳞癌、腺癌、小细胞肺癌患者和不同年龄健康者血清样本中MMP-9的表达水平，进行统计学分析。结果 MMP-9在肺癌患者血清中的含量明显高于健康人群；且伴有淋巴结转移组血清MMP-9水平显著高于无淋巴结转移组；在鳞癌组、腺癌、小细胞肺癌组组间差异无统计学意义；在不同年龄的健康组中差异无统计学意义 ...
HOU, Pan-fei +3 more
core +2 more sources
miR-4465靶向KPNA2调控宫颈癌细胞增殖、迁移及侵袭的机制研究
Zhongguo shiyan zhenduanxue, 2021 目的探讨微小RNA-4465(miR-4465)靶向核转运蛋白基因α2(KPNA2)调控宫颈癌细胞增殖、迁移及侵袭的分子机制。方法采用实时荧光定量聚合酶链反应(qRT-PCR)与蛋白免疫印迹法(Western blot)分别检测宫颈癌组织、癌旁组织中miR-4465、KPNA2的表达量;双荧光素酶报告检测miR-4465过表达对野生型和突变型KPNA2荧光素酶活性的影响;体外培养宫颈癌细胞Hela,利用脂质体法分别将miR-NC、miR-4465mimics、si-NC、si-KPNA2、miR ...
于利, 张明, 王迪
doaj
The study on the mechanism of topical propranolol gel in therapy of superficial infantile hemangiomas [PDF]
, 2015 目的：探讨外涂普萘洛尔凝胶对浅表型婴幼儿血管瘤（IHs）患儿血浆碱性成纤维生长因子（bFGF）、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子（VEGF）、肾素和血管紧张素Ⅱ（ATⅡ）水平的影响。初步探讨普萘洛尔凝胶治疗婴幼儿血管瘤的可能机制，以寻找治疗婴幼儿血管瘤高选择性用药，减少不良反应的发生。 方法：选取2013年2月至2014年2月厦门大学附属东方医院普通外科接受普萘洛尔凝胶治疗的33例婴幼儿血管瘤患儿，采用Achauer分级标准评估疗效，酶联免疫吸附试验（ELISA）检测患儿治疗前 ...
唐玉娟
core
Research progress of MDSCs-targeted immunotherapy for pancreatic cancer [PDF]
, 2023 Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
PENG Meiyu +4 more
core +1 more source
Evaluation value of combined detection of four serological indicators for the effect of concurrent chemoradiotherapy in cervical cancer [PDF]
Objective To explore the predictive value of combined detection of serum suppressor of cytokine signal 1 (SOCS1), matrix metalloproteinase-9 (MMP-9), squamous cell carcinoma antigen (SCCA), and thymidine kinase 1 (TK1) for clinical efficacy in cervical ...
LUO Qingbin, ZHENG Danning, WU Di
core +2 more sources
Network Pharmacology-based Research on Lipid Lowering Mechanism of Walnut Cold-press Meal [PDF]
, 2021 This paper explores the action mechanism of walnut cold-press meal in reducing fat from the perspective of network pharmacology.Active components and potential targets of walnut cold-press meal were obtained through TCMSP database and literature mining ...
CHEN Chao-yin +4 more
core +1 more source
Dieulafoy病的诊断与治疗(附9例病例分析) [PDF]
, 2004 目的 探讨Dieulafoy病的临床特点诊断及治疗方法。方法 回顾性分析9例Dieu lafoy病的临床表现、诊断、治疗方法。结果 均为上消化道大出血。胃镜确诊8例。手术确诊1例,胃镜下治愈7例。手术治愈2例。结论 提高对本病认识,急诊胃镜是首选诊断方法。内镜下止血为首选治疗方法 ...
刘忠臣, 吴艳环, 蒙国照
core
人参皂甙Rg3对乳腺癌细胞（MCF-7）表达金属蛋白酶2、9（MMP-2,MMP-9）的影响
Zhongguo shiyan zhenduanxue, 2005 目的为了研究人参皂甙Rg3对乳腺癌细胞（MCF-7）细胞分泌的基质金属蛋白酶（MMP-2,MMP-9）表达的影响。方法免疫组化法测定了用人参皂甙Rg3前后MCF-7细胞基质金属蛋白酶（MMP-2,MMP-9）的表达。结果分析表明人参皂甙Rg3能减少MCF-7细胞基质金属蛋白酶（MMP-2,MMP-9）表达。结论人参皂甙Rg3能抑制基质金属蛋白酶MMP-2、MMP-9的分泌。
李博, 于庭, 徐继杰
doaj
Establishment of gastric carcinoma cell clone with MMP-9 gene silence based on RNA interference [PDF]
, 2010 恶性肿瘤的主要特征是浸润和转移。根据文献报道，在浸润和转移过程中，基底膜和细胞外基质（ECM）的降解是关键环节。基质金属蛋白酶-9（MMP-9）作为蛋白水解酶的一种，它能特异性降解基底膜和ECM成分，从而促进肿瘤的浸润、转移及间质血管新生。胃癌组织MMP-9检测结果与临床病理资料对比研究表明，该酶的表达往往与胃癌的分化程度、病理类型、临床病理分期、浸润、转移和预后有关。但是，MMP-9在RNA干扰后对胃癌的影响机制尚不清楚。 RNA干扰是通过dsRNA介导的同源mRNA降解引起的相应转录后基因沉默 ...
蔡建春
core
Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma [PDF]
, 2023 Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. The high recurrence and metastasis rate have become a common clinical problem to be solved, but there is no effective treatment.
CHEN Junjun +5 more
core +1 more source