Results 31 to 40 of about 16,209 (168)
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】观察miR-34a在低氧诱导的大鼠肺动脉平滑肌细胞增殖中的作用并探讨其可能的机制。【方法】原代分离和培养大鼠肺动脉平滑肌细胞（PASMC），并给予3%低氧处理后，用Real-time PCR法检测miR-34a和Notch1mRNA在大鼠PASMC中的表达；低氧条件下用细胞转染法过表达和抑制miR-34a、沉默Notch1基因的表达后用EDU法观察细胞增殖情况，并用Real-time PCR和Western blot法检测细胞核增殖抗原PCNA的表达。【结果】分离和培养大鼠PASMC并给予3 ...
马兰
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Principal Physical Study and Burnup Calculation Analysis on Traveling-Wave Reactor [PDF]
, 2015 行波堆是快堆的一种，但具有常规快堆所不具备的特点，它是是一种趋近理想状态的先进核能系统，其焚烧策略可以实现一次装料连续运行数十年。本文使用蒙特卡罗计算程序MCNPX(MentoCarloNeutron-PhotonTransportCode)及其内耦合的燃耗计算程序CINDER90为计算工具，对行波堆的物理性质进行了初步研究，并对用于研究的计算工具的计算性能做了初步的探讨。 首先，本文参照泰拉能源原型堆的组件大小对其进行组件的均匀化，通过建立不同燃料棒尺寸，其他堆芯参数都相同的堆芯模型 ...
沈道祥
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Veterinary Dermatology, Volume 36, Issue 5, Page 668-678, October 2025.Background – Erythemato‐ceruminous otitis externa (ECOE) is commonly associated with Malassezia spp. and microbial imbalance. Hypothesis/Objective – To assess the clinical performance of an ear cleaner in dogs suffering from ECOE associated with Malassezia spp. overgrowth and to measure its impact on the microbiota. Conclusions and Clinical Relevance –
Amaury Briand +11 more
wiley +1 more source
双靶向TRAIL过表达联合辐射对乳腺癌MDA-MB-435细胞增殖和凋亡的影响
Zhongguo shiyan zhenduanxue, 2013 目的探讨Egr-1和hTERT双靶向介导TRAIL过表达联合辐射对乳腺癌细胞增殖和凋亡的作用,为肿瘤基因-放射治疗提供必要的参考。方法实验分为正常对照组（Control）、CRAd.pEgr-1-TRAIL组、2.0Gy照射组及CRAd.pEgr-1-TRAIL+2.0Gy照射组。病毒感染和X射线照射后,分别采用CCK-8试剂盒和AnnexinⅤ-FITC试剂盒检测细胞增殖和细胞凋亡。结果随着时间延长,各组细胞均表现增殖状态,control和CRAd.pEgr-1-TRAIL组MDA-MB ...
王巍, 陈文庆, 王长青, 徐贵颖
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Design, Synthesis and Evaluation of Novel Benzamide Derivatives as Antitumor Agents [PDF]
, 2016 肿瘤作为威胁人类身体健康的一种重大疾病，其治疗一直被全世界所重视。随着研究的不断深入，研究发现肿瘤是复杂的疾病，其生长和存活不仅仅依赖于一种受体或一种信号通路。单一靶点药物不能阻断肿瘤的所有信号通路，而联合用药又有可能影响药物的吸收和代谢，甚至造成更加严重的药物不良反应。因此，多靶点抗肿瘤药物随之诞生，它能够同时作用于某一肿瘤的多个靶点从而产生多种药理活性。相较于单一靶点而言，具有避免药物相互影响、作用全面、不良反应少等优势。 本文以课题组前期研究中发现的化合物HJ-47和YSM-14为先导化合物 ...
黄志宁
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Integrative Conservation, Volume 4, Issue 3, Page 381-392, September 2025.Grazing bans improved vegetation but increased predator activity, reducing pheasant nesting success in Giant Panda National Park—highlighting trade‐offs in conservation policy. ABSTRACT Grazing has a profound impact on forest ecosystems and biodiversity.
Yifei Zhang +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究CpGODN在体外刺激人PBMC的增殖情况。方法分别以肿瘤抗原（Ag）、白细胞介素-2（IL-2）和CpGODN单独或联合刺激正常人和肿瘤患者PBMC,并对其增殖活性进行测定。结果以CpGODN刺激人PBMC组的细胞增殖活性明显高于对照组 ...
李金龙, 耿力, 韩刚, 贾明库
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Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma [PDF]
, 2010 Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell ...
Baohui HAN +4 more
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Fluctuating salinity during development impacts fish life histories
Journal of Animal Ecology, Volume 94, Issue 9, Page 1848-1865, September 2025.Global freshwater ecosystems are increasingly threatened by salinisation. Salinity levels not only rise but also fluctuate due to extreme climate events and human activities. This study shows that stable elevated salinity accelerates reproduction in a freshwater fish, but fluctuations in salinity reduce reproductive output, with sex‐specific effects on
Meng‐Han Joseph Chung +4 more
wiley +1 more source
野生动物学报, 1995 麻雀的消化道在繁殖期总重量、鲜重及干重均高于繁殖前期，分别增加了６１．２１％、３９．４２％和３２．１２％。其中小肠的长度、重量、鲜重及干重也明显增加了４．９２％、１３２．９５％、１７３．７４％和１２８．３３％，而胃内含物重量的增加更为显著。表明了鸟类在繁殖期间通过改变消化道的形态以增加对能量的需求，是鸟类保证繁殖成功的生存对策之一．
柳劲松 +4 more
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