Results 31 to 40 of about 17,261 (166)
Mechanism of Mst1/2 kinases regulating PKCα-mediated the activation of Rac1 [PDF]
, 2016 当病原细菌入侵机体时，吞噬细胞（如巨噬细胞和嗜中性粒细胞等）会通过吞噬泡吞噬细菌；这一过程还伴随着线粒体以及NADPH氧化酶向吞噬泡募集并释放大量的ROS，来杀伤和清除病原细菌；其中，结合GTP的激活形式的RhoGTP酶蛋白家族成员Rac1和Rac2对于NADPH氧化酶激活的细胞吞噬过程是必需的。本实验室已有研究表明，在髓系细胞（单核细胞、巨噬细胞和嗜中性粒细胞等）条件性双敲除Mst1和Mst2的小鼠（Mst1fl/flMst2fl/flLyz2-Cre，cDKO）中，与野生型小鼠相比 ...
熊晓琳
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
双靶向TRAIL过表达联合辐射对乳腺癌MDA-MB-435细胞增殖和凋亡的影响
Zhongguo shiyan zhenduanxue, 2013 目的探讨Egr-1和hTERT双靶向介导TRAIL过表达联合辐射对乳腺癌细胞增殖和凋亡的作用,为肿瘤基因-放射治疗提供必要的参考。方法实验分为正常对照组（Control）、CRAd.pEgr-1-TRAIL组、2.0Gy照射组及CRAd.pEgr-1-TRAIL+2.0Gy照射组。病毒感染和X射线照射后,分别采用CCK-8试剂盒和AnnexinⅤ-FITC试剂盒检测细胞增殖和细胞凋亡。结果随着时间延长,各组细胞均表现增殖状态,control和CRAd.pEgr-1-TRAIL组MDA-MB ...
王巍, 陈文庆, 王长青, 徐贵颖
doaj
The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]
, 2016 目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
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World Medical &Health Policy, Volume 17, Issue 4, Page 688-694, December 2025.ABSTRACT The study by Morshed‐Behbahani et al. highlights that financial barriers are not the sole obstacle to accessing infertility treatment. To ensure equal access for all, infertility treatment should be regarded as a universal human right, with the public sector assuming responsibility for its provision.
Arturs Kalva, Girts Brigis
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究CpGODN在体外刺激人PBMC的增殖情况。方法分别以肿瘤抗原（Ag）、白细胞介素-2（IL-2）和CpGODN单独或联合刺激正常人和肿瘤患者PBMC,并对其增殖活性进行测定。结果以CpGODN刺激人PBMC组的细胞增殖活性明显高于对照组 ...
李金龙, 耿力, 韩刚, 贾明库
doaj
Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]
, 2015 Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
core
Review of additively manufactured zinc alloys by laser powder bed fusion for biomedical applications
Rare Metals, Volume 44, Issue 11, Page 8262-8291, November 2025.Graphical abstract AbstractZinc (Zn) and its alloys have emerged as promising candidates for biomedical materials, owing to their controlled degradation kinetics, intrinsic biocompatibility, and the release Zn2+ ions which are known to promote bone regeneration and tissue healing.
Xuan Yang +5 more
wiley +1 more source
野生动物学报, 1995 麻雀的消化道在繁殖期总重量、鲜重及干重均高于繁殖前期，分别增加了６１．２１％、３９．４２％和３２．１２％。其中小肠的长度、重量、鲜重及干重也明显增加了４．９２％、１３２．９５％、１７３．７４％和１２８．３３％，而胃内含物重量的增加更为显著。表明了鸟类在繁殖期间通过改变消化道的形态以增加对能量的需求，是鸟类保证繁殖成功的生存对策之一．
柳劲松 +4 more
doaj
Shuitu Baochi Xuebao, 2020 为了探索腐殖酸对土壤水盐运移特征及入渗参数的影响，进行了5种施量（0，1，3，5，7 g/kg）的一维垂直入渗试验。结果表明，入渗时间相同，累积入渗量和湿润锋均随腐殖酸施量的增加而减小；相同入渗深度随腐殖酸施量的增加所需的入渗时间、累积入渗量、剖面平均含水量均不断增加。入渗完成时相较于CK，施量为7 g/kg时累积入渗量、含水量分别增加8.0%，10.0%；施加腐殖酸可促进土壤剖面盐分向土壤深层运移并有效降低土壤pH，相较于CK施量为7 g/kg时0—20 cm土层平均脱盐率增加10.2 ...
李晓菊 +4 more
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