Results 101 to 110 of about 24,580 (225)

Generation and Characterization of HCMV Specific Human Antibody to Explore Antibody Response Profile in HCMV Naturally Infected Individuals [PDF]

open access: yes, 2015
人巨细胞病毒(Humancytomegalovirus,HCMV)是一种常见的疱疹病毒,在人群中普遍感染,儿童感染率约为10%-40%,成人为50%-90%,大部分感染者为无临床症状的健康人。但机体免疫功能低下的人群如器官移植患者及AIDS病人,更易发生HCMV病毒的新发或复发感染,引起致命疾病如肺炎、肝炎、脑炎等,从而导致器官移植失败及术后死亡;同时HCMV病毒也是宫内感染中危害最大的病毒之一,感染率占怀孕妇女的0.5%-2%,尤其是在发展中国家较为常见,孕妇感染后自身多无明显症状或轻微症状 ...
夏琳
core  

Harnessing social media data to track species range shifts

open access: yesConservation Biology, EarlyView.
Abstract Biodiversity monitoring programs and citizen science data remain heavily biased toward the Global North. Especially in megadiverse countries with limited biodiversity records, incorporating social media data can help address existing data gaps.
Shawan Chowdhury   +15 more
wiley   +1 more source

肾素-血管紧张素系统基因多态性与慢性心力衰竭的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2006
[目的]探讨中国南方汉族人群中,血管紧张素转换酶(ACE)及血管紧张素原(AGT)双基因多态性与慢性心力衰竭发病的关系.[方法]用聚合酶链反应及限制性片段长度多态性技术检测111例慢性心力衰竭患者和110例健康者的ACE基因I/D及AGT基因M235T的多态性.[结果]①慢性心力衰竭组DD基因型与D等位基因的频率均高于对照组.DD基因型0.468比0.227,P<0.01;D等位基因0.667比0.436,P<0.01.②AGT基因M235T多态性在慢性心力衰竭组及对照组的分布无统计学差异 ...
doaj  

Biodiversity‐driven spatial conservation planning to delineate temporally stable regions

open access: yesConservation Biology, EarlyView.
Abstract The accelerating loss of biodiversity underscores the critical need for effective conservation strategies, particularly in the face of climate change and anthropogenic pressures. We devised a conservation planning framework that adopts a temporal stacking approach to species distribution models and landscape connectivity analyses. These models
Mattia Iannella   +5 more
wiley   +1 more source

遗传性多发性骨软骨瘤致病基因EXT1和EXT2的多态性研究

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2011
【目的】研究EXT1与EXT2基因在我国南方正常人及致病性突变已明确的遗传性多发性骨软骨瘤病人中的多态性。【方法】 选取50例中国南方健康汉族个体及13例致病突变已明确的遗传性多发性骨软骨瘤病人,提取基因组DNA,对包含5’UTR区、编码区、外显子-内含子交界区及3’UTR区的PCR产物进行直接测序。 鉴定基因内的遗传变异,并将结果和国际数据库中的数据进行对比。【结果】 在所有研究对象中共发现15个不同的EXT1基因的单核苷酸多态性(SNPs):3个在编码区,为同义突变,11个在内含子区,1个在3 ...
doaj  

IRF5 rs10954213基因多态性与系统性红斑狼疮的相关性研究

open access: yesZhongguo shiyan zhenduanxue, 2009
目的研究山东地区汉族人群干扰素调节因子5(IRF5)基因rs10954213单核苷酸多态性,探讨其与系统性红斑狼疮易感性之间的关系。方法采用聚合酶链反应和限制性片段长度多态性等方法对92例系统性红斑狼疮患者和88名健康对照IRF5基因rs10954213G/A多态性进行分析,计算基因型和等位基因频率。结果SLE患者IRF5rs10954213GG、GA、AA基因型频率分别是0.318、0.409和0.273,与对照组间有显著差异(χ2=6.36 ...
宋卫青   +4 more
doaj  

Relationship between IL-17A gene polymorphism and susceptibility to Kawasaki disease. [PDF]

open access: yesZhong Nan Da Xue Xue Bao Yi Xue Ban, 2023
Yang Y   +5 more
europepmc   +1 more source

Effects of ApoE Isoforms Expression on Brain ApoE Lipidation and Amyloid-β Accumulation [PDF]

open access: yes, 2015
在编码人三种不同apoE蛋白亚型(E2、E3和E4)的APOE等位基因(ε2、ε3和ε4)中,APOEε4等位基因是阿尔茨海默病(Alzheimer’sdisease,AD)最重要的遗传风险因子,APOEε2等位基因则具有保护作用。鉴于apoE蛋白亚型对基于调节apoE蛋白表达的AD治疗可能会有不同的影响,我们通过在人APOE基因定位替换(Targetedreplacement,TR)小鼠脑中过表达不同的人apoE亚型,研究脑中表达不同apoE亚型对apoE脂化和β-淀粉样蛋白(Amyloid-β,Aβ)
胡进
core  

Overlap of nonbreeding wandering albatrosses with fisheries and implications for colony‐specific population trajectories at South Georgia

open access: yesConservation Biology, EarlyView.
Abstract Bycatch in fisheries is one of the most serious threats to pelagic seabirds, causing major population declines. Mitigation measures can reduce bycatch substantially, but many fisheries fail to apply best practices, and seabird mortality remains high.
V. Warwick‐Evans   +2 more
wiley   +1 more source

TLR-9 rs187084基因多态性与山东汉族人群系统性红斑狼疮的相关性研究

open access: yesZhongguo shiyan zhenduanxue, 2009
目的研究山东地区汉族人群TLR-9基因rs187084单核苷酸多态性,探讨其与系统性红斑狼疮易感性之间的关系。方法采用聚合酶链反应和限制性片段长度多态性等方法对92例系统性红斑狼疮患者和88名健康对照TLR-9基因rs187084C/T多态性进行分析,计算基因型和等位基因频率。结果(1)SLE患者TLR-9基因rs187084CC、CT、TT基因型频率分别是0.185、0.413和0.402,与对照组相比没有统计学差异(χ2=2.99,P>0.05);(2)SLE患者TLR-9基因rs187084C ...
宋卫青   +4 more
doaj  

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