Results 1 to 10 of about 582,698 (160)

水貂源致病性大肠杆菌对喹诺酮类药物耐药表型与耐药基因型检测与分析

野生动物学报, 2021
为了分析水貂源致病性大肠杆菌对喹诺酮类药物耐药表型与耐药基因型相关性，采用KB药敏纸片法和PCR法分别检测临床分离的15株水貂源致病性大肠杆菌耐药性与耐药表型。结果表明，15株水貂源致病性大肠杆菌对恩诺沙星、诺氟沙星、氧氟沙星、环丙沙星耐药率为467%—267%，呈现多重耐药性；耐药基因gyrA、gyrB 、qnrA、pare、qnrB检出率为80%—100%，其他耐药基因检出率为7%—40%，呈现多种耐药基因型；恩诺沙星、诺氟沙星、氧氟沙星、环丙沙星耐药表型与耐药基因gyrA、gyrB ...
郭家媚 1 葛成 1 张文斌 1 吴同垒 1 张志强 1 贾青辉 1 张召兴 1, 2 张艳英 1   +1 more
doaj   +1 more source

Is fluoroscopy‐guided percutaneous bone biopsy of diabetic foot with suspected osteomyelitis worthwhile? A retrospective study 一项回顾性研究:怀疑骨髓炎的糖尿病足在透视引导下经皮骨活检是否具有价值?

Journal of Diabetes, Volume 15, Issue 4, Page 332-337, April 2023., 2023
Abstract Background Diabetic foot infection, particularly osteomyelitis, is a major risk factor of amputation in persons with diabetes. Bone biopsy with microbial examination is considered the gold standard of diagnosis of osteomyelitis, providing information about the offending pathogens as well as their antibiotics susceptibility.
Hassan Al‐Balas, Zeyad A. Metwalli, Aaditya Nagaraj, David M. Sada   +3 more
wiley   +1 more source

The nose is not enough: Multi‐site sampling is best for MRSP detection in dogs and households

Veterinary Dermatology, Volume 33, Issue 6, Page 576-580, December 2022., 2022
Abstract Background Following recovery from meticillin‐resistant Staphylococcus pseudintermedius (MRSP) infection of any type, dogs may continue to carry MRSP asymptomatically on skin and mucosae, contributing to the spread of this multidrug‐resistant, veterinary hospital‐associated pathogen with zoonotic potential to others and into the environment ...
Sian‐Marie Frosini, Ross Bond, Ruth H. King, Anette Loeffler   +3 more
wiley   +1 more source

Nonalcoholic fatty liver disease in relation to the remission and progression along the glycemic continuum 非酒精性脂肪性肝病与血糖的缓解和进展

Journal of Diabetes, Volume 14, Issue 9, Page 606-619, September 2022., 2022
Highlights To what extent NAFLD is associated with glycemic remission among the general population remains unclear. The study elaborated that presence of NAFLD and fibrosis status decreased the chance of glycemic remission whereas NAFLD improvement mitigated glycemic deterioration, emphasizing joint management to liver‐focused subgroups of diabetes ...
Zhuojun Xin, Jiaojiao Huang, Qiuyu Cao, Jialu Wang, Ruixin He, Tianzhichao Hou, Yi Ding, Jieli Lu, Min Xu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu, Mian Li   +15 more
wiley   +1 more source

DUAL I China: Improved glycemic control with IDegLira versus its individual components in a randomized trial with Chinese participants with type 2 diabetes uncontrolled on oral antidiabetic drugs DUAL I China:在一项对未服用口服降糖药物的中国2型糖尿病患者进行的随机试验中, IDegLira与其单独成分相比改善了血糖控制

Journal of Diabetes, Volume 14, Issue 6, Page 401-413, June 2022., 2022
Highlights Insulin degludec/liraglutide (IDegLira) has good efficacy and tolerability in Chinese adults with type 2 diabetes not controlled on oral antidiabetic drugs. IDegLira provides the clinical advantages of insulin and glucagon‐like peptide 1 receptor agonists, improving glycemic control while reducing the main adverse effects of insulin (weight ...
Weiqing Wang, Bue F. Ross Agner, Bin Luo, Lei Liu, Ming Liu, Yongde Peng, Shen Qu, Karolina Amelia Stachlewska, Guixia Wang, Guoyue Yuan, Qiu Zhang, Guang Ning   +11 more
wiley   +1 more source

Evaluation of the effects of chlorhexidine digluconate with and without cBD103 or cCath against multidrug‐resistant clinical isolates of Staphylococcus pseudintermedius

Veterinary Dermatology, Volume 33, Issue 1, Page 17-e6, February 2022., 2022
Background – Because of the increased incidence of multidrug‐resistant (MDR) bacteria, the use of disinfectants over antibiotics has been encouraged. However, the interactions between disinfectants and host local immunity are poorly understood. Objective – To assess the effects of chlorhexidine digluconate (Chx), with and without selected host defence ...
Domenico Santoro, Lopamudra Kher, Vanessa Chala, Christelle Navarro   +3 more
wiley   +1 more source

载顺铂磁性纳米药物药动学研究

, 2011
目的高效液相色谱法（HPLC）测定血浆中顺铂（DDP）含量，研究载顺铂磁性纳米药物在家兔体内的药动学特征及其相关药动学参数。方法家兔12只，随机分为2组。分别于兔耳缘静脉注射3mg·kg^-1（按DDP含量计）剂量载顺铂磁性纳米药物和DDP，按设定时间于对侧耳缘动脉采血，通过改良HPLC法测定血浆中DDP浓度。以3P97药动学程序处理血浆药物浓度．时间数据，进行药动学分析。结果本实验单剂量静注DDP在家兔体内的药动学特征符合二室模型，载顺铂磁性纳米药物则符合三室模型。主要动力学参数与DDP相比 ...
谢民强, 陈帅君, 徐雪青, 张宏征, 沈辉, 万良财   +5 more
core   +5 more sources

医院碳青霉烯耐药肺炎克雷伯菌的耐药特征分析

Zhongguo shiyan zhenduanxue, 2022
目的 分析碳青霉烯耐药肺炎克雷伯菌的耐药表型和基因型等特征，为临床抗感染治疗提供实验依据。方法 收集2017年5月至2021年4月间住院患者感染性标本中分离的碳青霉烯耐药肺炎克雷伯菌，采用VITEK-2compact全自动细菌鉴定/药敏分析系统对碳青霉烯耐药菌株进行鉴定和药敏试验，应用SPSS Statistics 17.0软件进行耐药率差异分析。结果 共获得碳青霉烯耐药肺炎克雷伯菌55株，耐药菌株来源于痰液标本31株、尿液标本14株、血液标本10株；药敏结果显示 ...
孙胜君, 张昌莲, 赵自云
doaj  

结核分枝杆菌对一线抗结核药物的耐药情况分析

Zhongguo shiyan zhenduanxue, 2020
目的了解东莞市2015-2018年结核分支杆菌对四种一线抗结核药物的耐药情况以及耐药患者人群分布特征,为制定科学的耐药结核病治疗和预防策略提供依据。方法收集东莞市2015-2018年登记的痰培养阳性的肺结核患者3975例,菌群鉴定为结核分支杆菌的标本进行药敏试验。药敏试验采用比例法,药物敏感试验药物种类包含异烟肼（INH）、利福平（RFP）、链霉素（SM）、乙胺丁醇（EMB）四种一线抗结核药物。结果 3751株结核分枝杆菌对一线抗结核药物总体耐药率为25.70%（964/3751 ...
闫莉, 钟明浩, 关福源, 代艳杰, 罗兰娇   +4 more
doaj  

An Organo‐Pt(II) Photosensitizer With Robust Photo‐Assisted Antibacterial and Wound Recovery Performances in Diabetic Mice Wound Model

Rare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT The pathogenesis of diabetic foot ulcers is complex, often involving polymicrobial infection and persistent inflammatory responses, which lead to delayed or nonhealing wounds, posing a formidable clinical challenge. Existing photodynamic therapy reagents and traditional treatments generally address only a single pathological aspect, and the ...
Yu Zhang, Mengyao Han, Qianqian Cheng, Yin Jie, Qianqian Zheng, Ziwei Xu, Beixi Shi, Yueqi Zhao, Xiaofei Yang, Guangjie Zhong, Chenchen Chang, Xiaoxiao Yin, Xinai Zhong, Zhengru Fu, Shuying Bai, Hui Chong, Chengyin Wang   +16 more
wiley   +1 more source