Nanodrug delivery in reversing multidrug resistance in breast cancer cells [PDF]
, 2016 乳腺癌细胞产生多药耐药（Multidrugresistance，MDR）是乳腺癌化疗失败最主要的原因之一，深入研究拮抗或逆转乳腺癌多药耐药有着重要的理论和临床意义。紫杉醇（Paclitaxel，PTX)是目前临床上广泛应用的广谱抗癌药物。临床广泛使用的紫杉醇制剂（商品名“泰素”）毒副反应严重，超敏反应强烈，无明显靶向性，可诱发多药耐药，因此紫杉醇新制剂研究是当前国际国内的热点问题。 本文旨在研制出具有良好临床适应性、可逆转肿瘤多药耐药的紫杉醇纳米制剂，并使其具有磁靶向和光动力治疗的多重功能。首先 ...
王颖君
core
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2020 目的了解东莞市2015-2018年结核分支杆菌对四种一线抗结核药物的耐药情况以及耐药患者人群分布特征,为制定科学的耐药结核病治疗和预防策略提供依据。方法收集东莞市2015-2018年登记的痰培养阳性的肺结核患者3975例,菌群鉴定为结核分支杆菌的标本进行药敏试验。药敏试验采用比例法,药物敏感试验药物种类包含异烟肼（INH）、利福平（RFP）、链霉素（SM）、乙胺丁醇（EMB）四种一线抗结核药物。结果 3751株结核分枝杆菌对一线抗结核药物总体耐药率为25.70%（964/3751 ...
闫莉 +4 more
doaj
Studies on the regulation of membrane microdomains (lipid rafts) / Flot to mitogen-activated protein kinase signaling pathway and its effect on reversing multidrug resistance of hepatocellular carcinoma cells [PDF]
, 2015 目的： 1.构建耐药肝癌细胞模型。 2.检测Flot下调对ERK1/2信号通路的影响，明确能否通过Flot调控ERK1/2信号通路从而实现肝癌细胞耐药性的逆转。 3.检测脂筏破坏剂甲基-β-环糊精破坏脂筏结构对ERK1/2的影响，探索脂筏与ERK1/2之间的关联。 4.检测下调Flot对耐药肝癌细胞侵袭能力的影响。 5.构建过表达质粒Flot1/pcDNA3.1（+）、Flot2/pcDNA3.1（+），为后续研究工作奠定基础。 方法： 1.用阿霉素大剂量冲击法诱导细胞，Celltiter ...
王亚丽
core
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 研究发现,神经内科病区、医院的重症监护病房(ICU)以及神经外科病区等,病原菌耐药率相较于医院病原菌的整体耐药水平要高出许多,与此同时,其高耐药性与多重耐药性(MDROs)等特征也较为明显,在医院多重耐药菌检出率科室中位居前列[1]。在治疗过程中侵入性操作增加了医院多重耐药菌感染的风险[2]。多重耐药菌的流行增加了不良临床结果的发生率,延长了住院时间,提高了医疗成本。因此,降低神经内科重症住院患者多重耐药菌感染的发生率,提高患者的生活质量,已成为临床医护人员重点关注的问题[3 ...
南鹤, 蔡媛媛, 黄丹
doaj
Involvement of Abnormal MicroRNA Expression in the Mechanism of Drug Resistance with Acute Myeloid Leukemia [PDF]
, 2016 目的：分析miRNA-98的表达异常在急性髓系白血病化疗耐药机制的作用，通过靶向过表达miRNA-98的表达水平探讨以miRNA-98为靶点增加化疗药物敏感性的可能性并分析其可能作用的机制。评价异常表达的血清miRNA-155是否可作为急性髓系白血病的预后标志。 方法：离体实验中，采用qRT-PCR方法检测K562和其耐药株K562/A02中miR-98、E2F1基因表达情况。通过瞬时转染miR-98mimic处理耐药细胞K562/A0248h后，通过qRT-PCR法检测miR-98表达情况；通过qRT-
黄英丹
core
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
Total Synthesis of Hapalosin and Its Analogues：Construction of Three Small Hapalosin C-9 Analogues Libraries and Studies on Total Synthesis of Melleumins A and B [PDF]
, 2007 环肽类化合物是一类结构复杂多样的天然产物。自然界中存在大量的环肽类化合物，表现出多种生物活性，如杀虫、抗菌、抗肿瘤、抗病毒、和免疫抑制等。环肽类化合物作为富有实用前景的先导化合物在药物发现中受到越来越多的关注，新的活性天然产物也不断被发现。同时，环肽类天然产物的全合成也成为不对称合成的新热点。Hapalosin(1a)是1994年从蓝藻中分离提取的一类新型结构的环肽化合物，因其对肿瘤细胞的多药耐药性细胞系有很强的抑制作用，一经发现就引起了广大合成化学家和药物化学家的关注。本论文的目标在于拓展手性合成砌块(
戴朝峰
core
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He +11 more
wiley +1 more source