Results 21 to 30 of about 583,411 (160)
Zhongguo shiyan zhenduanxue, 2021 研究发现,神经内科病区、医院的重症监护病房(ICU)以及神经外科病区等,病原菌耐药率相较于医院病原菌的整体耐药水平要高出许多,与此同时,其高耐药性与多重耐药性(MDROs)等特征也较为明显,在医院多重耐药菌检出率科室中位居前列[1]。在治疗过程中侵入性操作增加了医院多重耐药菌感染的风险[2]。多重耐药菌的流行增加了不良临床结果的发生率,延长了住院时间,提高了医疗成本。因此,降低神经内科重症住院患者多重耐药菌感染的发生率,提高患者的生活质量,已成为临床医护人员重点关注的问题[3 ...
南鹤, 蔡媛媛, 黄丹
doaj
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT The pathogenesis of diabetic foot ulcers is complex, often involving polymicrobial infection and persistent inflammatory responses, which lead to delayed or nonhealing wounds, posing a formidable clinical challenge. Existing photodynamic therapy reagents and traditional treatments generally address only a single pathological aspect, and the ...
Yu Zhang +16 more
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Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou +6 more
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Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling +9 more
wiley +1 more source
热化疗逆转人肝癌细胞系BEL-7402/ADM多药耐药性的实验研究
Zhongguo shiyan zhenduanxue, 2005 目的 研究热化疗对多药耐药人肝癌细胞系BEL- 74 0 2 /ADM耐药性的影响并探讨相关的机制。方法 通过MTT法测定热化疗对多药耐药人肝癌细胞系BEL -74 0 2 /ADM耐药性影响;利用流式细胞仪检测多药耐药相关基因（MDR）的表达产物P糖蛋白（P- gp）、多药耐药相关蛋白（MRR）、谷胱甘肽转移酶（GSH/GST）的表达。结果 热化疗使多药耐药人肝癌细胞系BEL- 74 0 2 /ADM耐药性降低;P -gp、MRP和GSH/GST的表达均有所下降。结论 ...
王宁, 杨海山, 刘洁, 李玉
doaj
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的建立人肝癌多药耐药细胞系并研究其耐药特性及机制。方法应用人肝癌细胞株HepG2,采用阿霉素（ADM）浓度梯度递增诱导法,建立多药耐药细胞系HepG2/ADM。相差显微镜观察细胞,用MTT法检测该耐药细胞株对多种化疗药物的多药耐药性,采用流式细胞术检测该耐药细胞表面多药耐药基因（mdr）的表达产物P糖蛋白（P-gp）、多药耐药相关蛋白（MRP）及谷胱甘肽硫转移系统（GSH/GST）的表达情况,应用RT-PCR检测MDR、MRP基因表达水平。结果HepG2/ADM对多种抗癌药物产生耐药 ...
王宁, 李玉, 刘洁
doaj
Zhongguo shiyan zhenduanxue, 2022 目的 探讨吉林省2018年到2020年4个地市178名结核病患者结核分枝杆菌药物一线及二线敏感性检测结果,为吉林省结核病防治策略的制定提供依据。方法 根据Microsoft Excel 2013软件建立数据库,使用SPSS23.0软件对吉林省2018-2020年178名结核病患者阳性培养物的药敏检测结果进行数据分析。结果 随机抽取的178名患者耐药率为48.3%,其中单耐药患者35名(19.7%),耐多药患者18名(10.1%),多耐药患者15名(8.5%),广泛耐药患者5名(2.8 ...
doaj
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
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