Results 31 to 40 of about 6,978 (169)
Polypeptide Micelle-based Theranostic Nanoplatform for Overcoming Cancer Multidrug Resistance [PDF]
, 2016 癌症是全球范围内导致人口死亡的一个重要原因，在各种癌症中，胃癌是一 种较为高发的癌症，特别是在发展中国家。在发展中国家中，胃癌是造成男性死 亡的第三大死因。由于胃癌容易产生潜在的淋巴结转移，单纯的手术切除通常不 是很有效。因而，临床治疗过程中，常在手术切除肿瘤病灶后，常利用化学疗法 对晚期或是已经发生转移的胃癌进行治疗。化学疗法在癌症的治疗中已经得到广 泛的应用，但化学治疗的同时，也产生了一个新的问题，即癌细胞在经过化疗药 物治疗后，出现了耐药性。为了解决癌细胞对化疗药物耐药的问题，临床常选用 ...
杨彩霞
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Veterinary Dermatology, Volume 36, Issue 5, Page 552-565, October 2025.Abstract Background Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler +9 more
wiley +1 more source
BSD2000 Deep Hyperthermia Combined with Chemotherapy of PT regimen in Patients with Non-small Cell Lung Cancer [PDF]
, 2010 Background and objective The aim of this study is to determine the short-term efficacy, toxicity and the rate of life-quality improvement of BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer ...
Jun ZHAO, Mengxiang YANG, Yanwen WANG
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Veterinary Dermatology, Volume 36, Issue 3, Page 234-282, June 2025.Background – Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives – To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler +9 more
wiley +1 more source
Targeting TGF-β1/smad3 Signal Pathways activity in Cancer Stem Cells to reverse Multi-drug Resistance [PDF]
, 2013 背景及目的导致肝癌治疗失败、肿瘤复发和转移的原因之一是肿瘤耐药性的产生。肿瘤干细胞被认为是肿瘤化疗失败并产生多药耐药性的罪魁祸首。然而肿瘤干细胞与肿瘤耐药之间的相关性，以及针对肝癌化疗中多药耐药性寻找新的治疗策略仍然是个急需解决的重大难题。本研究的目的是应用抗癌药物阿霉素（ADM）诱导建立人肝癌多药耐药细胞Huh7.5.1/ADM，通过检测多药耐药细胞、亲本细胞和TGF-β1/smad3抑制剂SIS3处理耐药细胞的CD133和TGF-β1/smads信号通路的变化，初步探讨TGF-β1 ...
文霆
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Veterinary Dermatology, Volume 36, Issue 2, Page 148-158, April 2025.Background – Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.
Bhumika F. Savaliya +3 more
wiley +1 more source
Study on the influence of human hepatocellular carcinoma multidrug resistance by MAPK signal pathway and the downregulation of ERK1/2 on multidrug resistance reversion [PDF]
, 2012 目的： 1.用组织芯片和免疫组化技术检测肝癌组织中MAPK相关蛋白及多药耐药蛋白的表达，检测MAPK与肝癌多药耐药的关系。 2.用组织芯片检测MAPK相关蛋白、多药耐药蛋白及增殖指标的表达，分析其与临床特点及预后的关系，探索其指标对肝癌病人的临床意义。 3.化疗药物诱导建立多株人肝癌多药耐药模型，鉴定其耐药性，比较亲本株与耐药株生物学特点的差异。 4.用索拉菲尼及ERK抑制剂PD98059下调ERK后检测人肝癌细胞耐药株耐药性的变化，探索耐药细胞耐药性与ERK的关系。 方法： 1.制作组织芯片 ...
阮文雯
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Veterinary Dermatology, Volume 36, Issue 1, Page 14-23, February 2025.Background – Bacterial identification and antimicrobial susceptibility testing is an important step in timely therapeutic decisions for canine superficial bacterial folliculitis (SBF), commonly caused by Staphylococcus pseudintermedius. Next‐generation sequencing (NGS) offers the appeal of potentially expedited results with complete detection of ...
Kimberly Smart +4 more
wiley +1 more source
野生动物学报, 2022 为了分析火烈鸟(Phoenicopterus ruber)腹泻沙门菌(Salmonella)的致病性及耐药性情况,2016—2020年采集动物园中患腹泻火烈鸟的粪便、肛拭子和死亡火烈鸟的肝脏等病料组织102份,采用细菌分离鉴定和PCR方法进行沙门菌鉴定,采用人工感染小白鼠致病性试验和K-B药敏纸片法分别检测分离菌株的致病性和耐药表型情况。结果显示:从102份病料组织中分离得到89株沙门菌,其中75株沙门菌对小白鼠具有致病性,这75株沙门菌分离菌株对链霉素、阿莫西林、氨苄西林等14种药物耐药率在45.3 ...
邓丽玲 汪明权 李雨芮
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Multifunctional ferritin-based nanoparticles for co-drug delivery to circumvent cancer resistance [PDF]
, 2017 胃癌在最常诊断的癌症中居全球第四，癌症患者中，因胃癌死亡的原因占据第三。全球每年有951，600新病例和723，100死亡数。尽管胃癌的患病率在整个全球都很高，但在东亚是最高的。根据肿瘤进展情况，可选择手术、化疗和放射治疗对胃癌进行治疗。化疗是治疗转移性胃癌患者的首选，但是仅仅依靠手术治疗效果非常有限。并且化疗药物除了对机体有明显副作用外，另一个重要问题便是癌细胞对药物的耐受性增加，即耐药性出现（MDR）。而且一旦出现耐药性，即便是寻找可替代的化疗药物或者加大药物的使用量，都很难从根本上解决问题。因而 ...
高海燕
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