, 2007 超广谱β-内酰胺酶(extended specturn β-lactamerses,ESBLs)是丝氨酸蛋白酶的衍生物,它能够水解青霉素、广谱及超广谱头孢菌素和单环β-内酰胺抗生素的β-内酰胺酶,且能被克拉维酸抑制。ESBLs主要由肠杆菌科细菌产生,
周赞虎 +3 more
core
Zhongguo shiyan zhenduanxue, 2011 目的了解我院多重耐药鲍曼不动杆菌临床分离株中Ⅰ类整合子的流行情况,建立一种快速简便的Ⅰ类整合子聚合酶链反应（PCR）检测方法。方法收集我院2008年9月至2010年9月临床分离的鲍曼不动杆菌63株,用MIC法检测耐药性,PCR技术检测Ⅰ类整合子基因。结果 63株鲍曼不动杆菌中Ⅰ类整合子基因阳性率56%（35株）。Ⅰ类整合子阳性和阴性的鲍曼不动杆菌对各种抗生素的耐药性存在明显差异。结论我院多重耐药鲍曼不动杆菌中Ⅰ类整合子携带率高,携带的耐药基因为aaeA4、catB8和aadA1 ...
胡晓波 +6 more
doaj
The function of Genistein in Gastric Cancer Stem Cell-like Properties [PDF]
, 2014 染料木素，大豆中发现的一种主要的大豆异黄酮，多项研究表明其在体外和体内能够抑制不同类型肿瘤的发生发展。越来越多的证据显示在胃癌中有肿瘤干细胞的存在。我们发现，在胃癌肿瘤细胞MGC-803和SGC-7901中，通过软琼脂克隆形成和无血清瘤球形成实验表明，由丰城鸡血藤中提取的染料木素（15μM）能够抑制肿瘤细胞的自我更新能力。同时，染料木素能够提高胃癌细胞对化疗药物5-Fu和ciplatin的敏感性。我们的进一步结果表明，染料木素抑制胃癌细胞的干细胞特性与其诱导的miR-145的表达密切有关。此外 ...
黄卫锋
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Zhongguo shiyan zhenduanxue, 2018 目的探讨碳青霉烯酶在鲍曼不动杆菌对亚胺培南耐药中的作用,为临床合理用药及控制医院感染提供依据。方法收集临床分离非重复鲍曼不动杆菌100株,其中亚胺培南耐药和敏感各50株,琼脂稀释法检测上述细菌对18种抗菌药物的敏感性,改良霍奇(Hodge)试验进行碳青霉烯酶表型检测。PCR技术检测10种碳青霉烯酶基因携带情况。结果所有菌株对替加环素、多粘菌素B均敏感,亚胺培南耐药菌除对头孢哌酮/舒巴坦(32%)和米诺环素(30%)耐药率低外,对其他抗菌药物耐药率均较高,而亚胺培南敏感菌对多数抗生素均较敏感 ...
侯盼飞, 祝丽晶, 潘艳
doaj
[Analysis of multidrug resistance gene locus mutations and clinical significance in children with Mycoplasma pneumoniae pneumonia]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiZhang W, Wang Y, Cai LJ.
europepmc +1 more source
[Literature review and experience in treatment of multidrug-resistant bacterial infection in operative area after cochlear implantation]. [PDF]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za ZhiLuo W, Wu P, Lai Y, Cui Y, Huang H.
europepmc +1 more source
[Overexpression of lncRNA SNHG12 promotes docetaxel resistance of prostate cancer cells by activating PI3K/AKT signaling <i>via</i> interacting with ELAVL1]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhao C +5 more
europepmc +1 more source
[Antitumor component-Ι in <i>Agkistrodon halys</i> venom inhibits proliferation and migration of cisplatin-resistant gastric cancer cells by downregulating RAI14]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLi Y +7 more
europepmc +1 more source
["Chongqing experiences" in treatment of bone infections]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiXie Z.
europepmc +1 more source
[Guideline for the diagnosis and treatment of chronic myeloid leukemia in China (2025)]. [PDF]
Zhonghua Xue Ye Xue Za ZhiChinese Society of Hematology +1 more
europepmc +1 more source