, 2009 【目的】 观察细胞周期调控因子SKP265380;P27kip1在白血病耐药细胞株HL-60/A和非耐药细胞株HL-60细胞中的表达及细胞周期比例,探讨细胞增殖与耐药的关系65377; 【方法】 RT-PCR65380;Western blot 检测SKP265380;P27kip165380;MRP mRNA及蛋白表达,流式细胞仪检测细胞周期,采用药物毒性分析方法检测细胞对化疗药物的敏感性65377; 【结果】 白血病耐药细胞株HL-60/A对阿霉素65380;柔红霉素65380 ...
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[Everolimus inhibits malignant phenotype of erdafitinib-resistant bladder cancer cells through the p70S6K/PI3K/MAPK signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWu H, Jiang Y, Zhang X, Wang S.
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Zhongguo shiyan zhenduanxue不动杆菌属是革兰阴性杆菌，多为球杆形，不发酵糖类，对营养要求一般，可广泛存在于自然界和医院环境中[1-2]。痰液、尿液、血液、脓汁等标本中均可分离培养出不动杆菌属，是仅次于假单胞菌属的引起院内感染的重要致病菌[3-4]。近年来，不动杆菌属的分离率呈不断上升趋势，该菌属除了本身固有耐药机制，还可产生获得性耐药机制，因此容易对多种抗菌药物产生耐药性，临床用药的选择严重受限[5-7]。
褚为, 王莉, 宋伶俐, 马琳琳
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, 2013 目的研究中药Kacimex体内抗肿瘤的作用及初步机制。方法建立小鼠肝癌H22实体瘤模型,观察Kacimex胶囊对荷瘤小鼠胸腺、脾脏等免疫器官的影响;通过黄嘌呤氧化酶法、硫代巴比妥酸显色法观察Kacimex各浓度组对荷瘤小鼠血清中超氧化物歧化酶(SOD),丙二醛(MDA)含量的影响;免疫组化法观察Kacimex各浓度组对H22荷瘤小鼠瘤组织病理学形态的影响及对凋亡相关蛋白Bcl-2、Bax表达的影响。结果中药Kacimex能使各浓度组荷瘤小鼠的瘤组织不同程度的坏死;能显著降低MDA含量,提高SOD含量 ...
黄建春, 黄仁彬, 杨立芳, 焦阳
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[Characteristics and Drug Resistance Analysis of Urogenital Mycoplasma Infections in Patient Specimens From Non-Gynecologic Departments]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanZhou D, Yuan Y, Liu Y, Xiao Y.
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[Antimicrobial resistance characteristics of <i>Escherichia coli</i> in infants younger than 90 days]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiZhang DM +6 more
europepmc +1 more source
[Drug resistance characteristics of pulmonary tuberculosis and factors associated with rifampicin resistance in Changsha from 2018 to 2025]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanXie C, Yin P, Song L, Xiong Z.
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[Efficacy of fluconazole prophylaxis for late-onset invasive fungal infection in very preterm infants/very low birth weight infants: a retrospective cohort study based on propensity score matching]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiHuang FJ +11 more
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[A two-stage model for predicting postoperative pulmonary infection in esophageal cancer patients]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za ZhiWang Y, Yin L, Yao B, Wu J, Pu J.
europepmc +1 more source
[Novel therapeutic strategies for liver metastases driven by the common microenvironment]. [PDF]
Zhonghua Gan Zang Bing Za ZhiShen LX, Fang WJ, Tong Z.
europepmc +1 more source