Results 1 to 10 of about 6,253 (118)

Nonalcoholic fatty liver disease in relation to the remission and progression along the glycemic continuum 非酒精性脂肪性肝病与血糖的缓解和进展

Journal of Diabetes, Volume 14, Issue 9, Page 606-619, September 2022., 2022
Highlights To what extent NAFLD is associated with glycemic remission among the general population remains unclear. The study elaborated that presence of NAFLD and fibrosis status decreased the chance of glycemic remission whereas NAFLD improvement mitigated glycemic deterioration, emphasizing joint management to liver‐focused subgroups of diabetes ...
Zhuojun Xin, Jiaojiao Huang, Qiuyu Cao, Jialu Wang, Ruixin He, Tianzhichao Hou, Yi Ding, Jieli Lu, Min Xu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu, Mian Li   +15 more
wiley   +1 more source

DUAL I China: Improved glycemic control with IDegLira versus its individual components in a randomized trial with Chinese participants with type 2 diabetes uncontrolled on oral antidiabetic drugs DUAL I China:在一项对未服用口服降糖药物的中国2型糖尿病患者进行的随机试验中, IDegLira与其单独成分相比改善了血糖控制

Journal of Diabetes, Volume 14, Issue 6, Page 401-413, June 2022., 2022
Highlights Insulin degludec/liraglutide (IDegLira) has good efficacy and tolerability in Chinese adults with type 2 diabetes not controlled on oral antidiabetic drugs. IDegLira provides the clinical advantages of insulin and glucagon‐like peptide 1 receptor agonists, improving glycemic control while reducing the main adverse effects of insulin (weight ...
Weiqing Wang, Bue F. Ross Agner, Bin Luo, Lei Liu, Ming Liu, Yongde Peng, Shen Qu, Karolina Amelia Stachlewska, Guixia Wang, Guoyue Yuan, Qiu Zhang, Guang Ning   +11 more
wiley   +1 more source

Evaluation of the effects of chlorhexidine digluconate with and without cBD103 or cCath against multidrug‐resistant clinical isolates of Staphylococcus pseudintermedius

Veterinary Dermatology, Volume 33, Issue 1, Page 17-e6, February 2022., 2022
Background – Because of the increased incidence of multidrug‐resistant (MDR) bacteria, the use of disinfectants over antibiotics has been encouraged. However, the interactions between disinfectants and host local immunity are poorly understood. Objective – To assess the effects of chlorhexidine digluconate (Chx), with and without selected host defence ...
Domenico Santoro, Lopamudra Kher, Vanessa Chala, Christelle Navarro   +3 more
wiley   +1 more source

A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine‐month controlled study

Veterinary Dermatology, Volume 33, Issue 1, Page 55-e18, February 2022., 2022
Background – Canine atopic dermatitis (cAD) is a common chronic relapsing pruritic skin disease for which management commonly relies on life‐long use of immunomodulatory drugs. A number of the medications used are associated with adverse effects and the potential for complications during long‐term use.
Adrian Watson, Ana Rostaher, Nina M Fischer, Claude Favrot   +3 more
wiley   +1 more source

Whole genome sequencing and de novo assembly of Staphylococcus pseudintermedius: a pangenome approach to unravelling pathogenesis of canine pyoderma

Veterinary Dermatology, Volume 32, Issue 6, Page 654-663, December 2021., 2021
Background Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro‐organisms. Hypothesis/Objectives Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S.
Lluís Ferrer, Rocío García‐Fonticoba, Daniel Pérez, Joaquim Viñes, Norma Fàbregas, Sergi Madroñero, Gabriele Meroni, Piera A. Martino, Sofía Martínez, M. Laura Maté, Sergio Sánchez‐Bruni, Anna Cuscó, Lourdes Migura‐García, Olga Francino   +13 more
wiley   +1 more source

逆转骨肉瘤耐药的实验研究

Zhongguo shiyan zhenduanxue, 2021
目的构建骨肉瘤耐药细胞,探讨LIMK1(LIM Kinase1)逆转骨肉瘤耐药的作用及机制。方法通过长春新碱(VCR)诱导建立人成骨肉瘤MG63的耐药细胞亚系,应用半数抑制浓度公式计算IC50值及耐药指数评估细胞的耐药性;CCK-8法检测细胞增殖抑制率;相差倒置显微镜观察耐药细胞细胞形态的改变;PT-PCR实验检测耐药基因MDR1及其相关基因LIMK1的表达;转染pSUPER-LIMK1重组质粒,验证沉默LIMK1基因逆转MG63耐药的作用并分析其机制。结果本研究所构建的耐药细胞的耐药指数为7.01 ...
黄丽红, 秦迪, 徐为民, 高奕瑶, 王岩   +4 more
doaj  

Comparative Study on Foodborne Bacterial Antimicrobial Resistance Surveillance System in China, America and Europe and Its Implication(中美欧食源性细菌耐药性监测系统比较研究及启示) [PDF]

Shipin kexue jishu xuebao, 2023
Antimicrobial resistance (AMR) is involved in veterinary medicine, food, environment, medicine, and other fields. It endangers food safety, international trade, economic development, and life health. It has become a major public health problem facing the
LI Ning(李宁), BAI Li(白莉)
doaj   +1 more source

RBM5过表达后吉非替尼耐药肺癌细胞中RBM5、EGFR的表达

Zhongguo shiyan zhenduanxue, 2021
肺癌是常见肺原发恶性肿瘤,近年来随着EGFR抑制剂等基因靶向药物的问世,肺癌的治疗取得了长足的进步。吉非替尼是EGFR-TKI类靶向治疗的代表性药物,是一种口服的选择性EGFR酪氨酸激酶抑制剂。RBM5作为一个肿瘤抑制基因,前期研究发现RBM5与肺癌化疗耐药有关,可逆转肺腺癌细胞顺铂耐药性。本研究通过体外实验,检测RBM5过表达对吉非替尼耐药细胞EGFR基因表达及细胞增殖的影响,探讨RBM5在改善吉非替尼耐药中的作用,探寻其逆转耐药机制。
梁红, 王奕文, 智玥, 宋杨
doaj  

人胃癌耐药细胞的建立方法及意义

Zhongguo shiyan zhenduanxue, 2021
目的 建立人胃癌耐药细胞,为研究人胃癌耐药细胞的耐药机制以及为耐药肿瘤细胞的治疗提供耐药肿瘤细胞模型。方法 体外培养人胃癌细胞SGC-7901,用50μmol/L顺铂多次反复冲击,对冲击4次和6次的SGC-7901分别检测对顺铂的抑制率和多药耐药基因（MDR）及多药耐药特异基因片段的表达,并计算药物对细胞的半数抑制浓度（IC50）。结果 经4次和6次冲击后,受冲击的SGC-7901胃癌细胞对顺铂的抑制率明显高于亲本细胞,IC50为63.98μmol/L和66.34μmol/L,而亲本细胞SGC ...
刘玉侠, 齐红, 段北野, 付尧, 夏莉, 于鸿, 王斌   +6 more
doaj  

Synergistic Chemodynamic–Photothermal Antibacterial Activity of a Nanozyme Derived From Processed Pyritum

Rare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT Pyritum can eliminate blood stasis and promote the healing of muscles and bones, which has been used as a traditional mineral medicine in China for thousands of years. However, the mechanisms of action and processing methods of Pyritum were not illustrated.
Mingxia Li, Jia Li, Guo Feng, Yanan Li, Xiuping Ma, Qingfeng Pi, Yong Chen, Xianshu Wang, Mingxian Liu   +8 more
wiley   +1 more source