Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 探讨姜黄素预先给药对兔单肺通气导致的肺炎性损伤的影响及可能机制。【方法】 将12只健康新西兰白兔随机分为2组,每组6只:开胸单肺通气+对照剂组(组1)和开胸单肺通气+姜黄素组(组2)。两组兔经腹腔注射分别预先给予对照剂和姜黄素,每天早晚各1次。连续给药7 d后,两组兔均经口插入单腔气管导管行右侧单肺通气,并左胸开一小口模拟手术操作。分别于机械通气前(T0)及实验结束前(T4)采集动脉血行血气分析,计算氧合指数。处死动物后,行右侧支气管肺泡灌洗测定髓过氧化物酶 (MPO)含量及中性粒细胞数量 ...
李慧婷
doaj
Intervention effect of Chinese herb components HJJB Compound on PP1-DNA-PK-USF1 signaling pathway of non-alcoholic fatty liver rats [PDF]
, 2017 目的:基于蛋白磷酸酶(PP1)-DNA依赖的蛋白激酶(DNA-PK)-上游刺激因子1(USF1)信号通路,探讨中药组分HJJB方防治非酒精性脂肪; 肝(NAFLD)的作用机制。方法:采用高脂饮食诱导的大鼠NAFLD模型。设模型组、HJJB方组和罗格列酮组,分别灌胃给药6周。HE染色观察肝组织; 病理变化;测定肝组织甘油三酯(TG)、游离脂肪酸(FFA)含量的变化;肝组织PP1、DNA-PK、USF1; mRNA水平和蛋白含量的变化。结果:模型组肝组织出现显著的肝细胞脂肪变性及空泡样变,肝组织TG ...
周飞 +4 more
core
The neuroprotective effect of curcumin in a mouse model of Parkinson’s disease and its mechanism [PDF]
Objective To investigate the neuroprotective effect of curcumin on mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) and its mechanism.
WANG Ziyi, MAO Hua, JIN Tingting, ZHANG Xiangning, HAN Shuai, LIANG Yongxin
core +1 more source
Study on the mechanism of curcumin in the treatment of periodontitis through network pharmacology and mole-cular docking. [PDF]
Hua Xi Kou Qiang Yi Xue Za Zhi, 2023 Yang J, Zhou Z, Wu Y, Nie M.
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2012 前列腺癌细胞的多耐药性（multidrug-resistance,MDR）常常导致临床上前列腺肿瘤化疗的失败。研究耐药机制,寻找分子靶点,研发高效、低毒的MDR抑制剂是目前面临的挑战。研究表明,化疗药物诱导凋亡耐受在前列腺肿瘤细胞MDR形成过程中起着十分重要的作用。因此,寻找前列腺癌多耐药抑制剂,促进细胞凋亡可以在很大程度上降低前列腺癌MDR。
赵雷
doaj
[Curcumin suppresses proliferation, migration and invasion of papillary thyriod cancer B-CPAP cells through the Keap1-Nrf2 pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Ren L +7 more
europepmc +1 more source
Differences in In Vitro Digestibility of Curcumin Nanoemulsions Stabilized by Whey Protein Isolate and Whey Protein Isolate-(–)-Epigallocatechin-3-gallate [PDF]
In this study, the release of free fat acids (FFA) from and the digestion characteristics of curcumin nanoemulsions constructed using whey protein isolate (WPI)-(-)-epigallocatechin-3-gallate (ECGG) graft copolymers with 3% and 4% grafting degrees as ...
LI Yanxin, CHEN Liying, LI Yan, XIE Xin’an, LI Lu
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Effect of HJJB Compound on Insulin Signal Transduction Link of Non-alcoholic Steatohepatitis Rats [PDF]
, 2017 目的观察红景天苷、姜黄素、绞股蓝总苷、白术多糖(HJJB)复方对非酒精性脂肪性肝炎(NASH)大鼠胰岛素信号转导环节的干预作用。方法采用高脂饮食; 14周诱导的大鼠胰岛素抵抗NASH模型。在造模第9周起,随机分为模型组、西药组(罗格列酮,0.4; mg/kg)和中药组(HJJB)。干预6周后,观察肝组织病理变化(HE染色),检测肝组织TG含量、ALT活性、血清空腹胰岛素(FINS)含量、空; 腹血糖(FBG)含量、胰岛素抵抗指数(HOMA-IR),检测肝组织胰岛素受体底物1 (IRS1 ...
应豪 +4 more
core
Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 研究姜黄素对人宫颈癌细胞Caski侵袭转移的影响并探讨其可能的机制。【方法】 以10, 25, 50 μmol/L姜黄素处理Caski细胞24,48,72 h后,MTT法检测其对Caski细胞的生长抑制作用。应用Transwell小室进行人工重组基底膜(Matrigel)侵袭和运动实验,观察姜黄素对Caski细胞侵袭和转移的影响。Western blot检测细胞中MMP-2。MT1-MMP和NF-κB蛋白水平变化。 【结果】应用姜黄素处理后人宫颈癌细胞生长受到抑制且作用呈时效-量效依赖关系 ...
doaj
[Activity of curcumin against human cytomegalovirus infection in vitro]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2022 Ding X, Yue J, Dong B, Sean X L.
europepmc +1 more source