Results 61 to 70 of about 905 (144)
Zhongguo shiyan zhenduanxue, 2011 目的观察西洛他唑对慢性脑缺血大鼠皮层中低氧诱导因子-1α（HIF-1α）和HO-1表达的影响并探讨其发病机制。方法采用大鼠双侧颈总动脉永久性阻断法（2-VO）建立动物模型,Wistar大鼠随机分为假手术组、2-VO组和西洛他唑组,选取9周（n=10）时间点,应用Morris水迷宫实验测定大鼠的学习记忆能力,采用免疫组化法检测大鼠皮层HIF-1α和HO-I蛋白的表达。结果 2VO组和西洛他唑组大鼠逃避潜伏期和游泳路程均显著增加,但西洛他唑组大鼠的学习记忆成绩显著优于2VO组 ...
魏爱宣
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[Effect of inhibiting miR-204 expression on the learning and memory abilities of neonatal rats with intrauterine growth restriction and related mechanism]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Zhu DL +5 more
europepmc +1 more source
胰岛素降低海马谷氨酸及-Ｄ-丝氨酸含量改善糖尿病大鼠空间学习记忆能力 [PDF]
目的 观察胰岛素对糖尿病大鼠空间学习记忆及海马组织中谷氨酸、Ｄ-丝氨酸含量的影响。方法 采用尾静脉注射链脲佐菌素（ＳＴＺ）制备大鼠糖尿病（ＤＭ）模型。注射ＳＴＺ第３天模型成功后，每天 １次 ｓｃ给予胰岛素 ２Ｕ·ｋｇ－１，持续 ８２ｄ。定期检测各组动物体重及空腹血糖。造模 １１周后进行 Ｍｏｒｒｉｓ水迷宫实验，检测大鼠学习记忆能力；实验结束后取海马组织，观察形态变化，并测定谷氨酸及 Ｄ-丝氨酸含量。结果 与正常对照组比较，ＤＭ模型组大鼠体重明显减轻（Ｐ＜０．０１），血糖明显升高（Ｐ＜０．０１ ...
宋扬(辽宁医学院辽宁省心脑血管药物基础研究重点实验室) +6 more
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Gaoya dianqi, 2023 针对生弧材料弱化故障电弧特征和监督式学习方法依赖于大量标记数据的问题，提出了包络微分算子增强故障电弧特征，并采用半监督学习模型融合该特征辨识直流故障电弧和生弧材料的方法。首先依据UL 1699B搭建直流故障电弧实验平台，采集了铝、黄铜、不锈钢、石墨铸铁以及球墨铸铁常见电力设备材料下的故障电弧信号，再采用包络微分算子增强电弧小波特征，有效提升了多生弧材料条件下的故障电弧特征显著性。然后通过K-Means算法进行离群点检测，有效降低了同种生弧材料的特征波动 ...
陈思磊 +4 more
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Zhongguo shiyan zhenduanxue, 2013 发作性睡病是一种慢性潜在的、可致能力丧失的睡眠障碍性疾病,人群中10-20岁发病率最高[1],以睡眠过多,猝倒、睡瘫、睡眠幻觉为主要特征。虽不能对生命造成严重威胁,但影响正常工作、生活和学习,进而对情绪、心理产生负面影响。由于儿童正处于学习知识及生长发育阶段,发作性睡病常出现白日不分时间、场合的嗜睡,困倦导致记忆力减低、脾气暴躁,影响到学业及社会交往;有些时候过度困意又使他们反应迟钝,甚至被认为智力低下受到歧视;猝倒发作在就诊时可能误判为癫痫性疾病 ...
辛翠娟 +3 more
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Research progress on digestion, absorption and health efficacy of astaxanthin ester [PDF]
Astaxanthin is primarily found in both free and esterified forms in nature, With astaxanthin esters presenting various structural variations. These forms differ significantly in their digestive, absorption, and health-related functions compared to free ...
CHE Hongxia +4 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究血管性痴呆（VD）大鼠形成过程中PSD-95的变化规律及作用机制。方法永久性结扎双侧颈总动脉制备VD大鼠模型,用Morris水迷宫衡量大鼠的学习记忆水平,用免疫印记法检测大鼠海马PSD-95的表达。结果随缺血时间延长,VD大鼠的学习记忆能力下降,缺血4周后与对照有显著差异 ...
何雨, 李彤, 胡艳兵
doaj
Postbiotics Regulate Intestinal Microbiota and Reduce Amyloid β-Protein Deposition in the Brain, Thereby Ameliorating Cognitive Impairment in Rats with Alzheimer’s Disease [PDF]
This study aimed to investigate the impact of three postbiotics at different doses on cognitive function in a rat model of Alzheimer’s disease (AD) induced by D-galactose combined with AlCl3. Specific pathogen-free (SPF) Wistar rats were randomly divided
XIAO Ling, TANG Linlin, SONG Xiaoyan, ZHANG Yihua, HAN Xuemei, LÜ Houjiao, LIANG Wu, WANG Yanping, GENG Weitao, JIA Longgang
core +1 more source
, 2011 建立荧光高效液相色谱(fluorescence detector-high performance liquid chromatography,HPLC-FLD)测定母乳中唾液酸N-乙酰神经氨酸(N-acetylneuraminic acid,Neu5Ac)和N-羟乙酰神经氨酸(N-glycolyl neuraminic acid,Neu5Gc)含量的分析方法。利用酸水解法释放出母乳中的唾液酸,以4,5-亚甲二氧基-1,2-邻苯二胺盐(4,5-methylenedioxy-1,2 ...
李红卫, 王萍, 陈海娇, 陈越
core
Natto Ameliorates D-Galactose-Induced Aging in Mice through Regulating the PI3K/Akt Signaling Pathway and Intestinal Nutrient Metabolism [PDF]
Purpose: The effect of natto on the behavioral ability and nutrient metabolism of aging mice was investigated from the perspectives of the liver, muscle and intestine.
WANG Jing, HUA Mei, HE Yuguang, MIAO Xinyu, SUN Mubai, LI Da, NIU Honghong, YANG Luran, LU Jinyuan, XU Hongyan, WANG Jinghui
core +1 more source