Results 11 to 20 of about 1,266 (148)
Change of transcription factor EB activity and autophagy in hippocampus of type 2 diabetic encephalopathy mice [PDF]
, 2023 Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were randomly ...
CHEN Yixin +3 more
core +1 more source
Research Progress of Memory Improving Peptides(改善记忆肽研究进展) [PDF]
Shipin kexue jishu xuebao, 2015 Memory decline and degeneration can be associated with human health conditions, brain physiological aging, brain trauma, and pathologic changes. Due to the pressure caused by skyrocketing economic burden on society, from teenagers to the elderly all live
ZHAO Mouming(赵谋明) +2 more
doaj +1 more source
野生动物学报, 2021 主要综述了噪音对动物体学习和记忆的影响及其基本机制。研究结果表明，噪声暴露可以引起过度氧化应激、乙酰胆碱酯酶活性增加、髋关节内侧前额叶皮质区树突状细胞数量减少、血浆皮质酮水平升高，并导致空间学习记忆障碍。其中脑组织的氧化应激、胆碱能的下降、动物的恐惧调节、激素分泌、噪音性听力损失以及髋关节的改变和N甲基D天冬氨酸（NmethylDaspartate，NMDA）受体的介导可能是噪音引起认知障碍的主要机制。
彭鸿碧 1, 2, 3 朱万龙 1, 3
doaj
Effect of Neu5Ac supplementation on learning and memory in weanling rats and rat pups [PDF]
, 2016 研究背景：新生儿生长发育对营养物质有特殊的要求，任何营养素的匮乏对机体的正常生长和器官结构功能的发育都有深远影响，对脑发育的影响尤为重要。早期营养对大脑的结构和功能有着不可逆转的影响，一旦错过大脑发育的关键期，产生的缺陷后天将无法弥补。新生儿期营养素的缺乏会影响其认知功能。 N-乙酰神经氨酸（N-acetylneuraminicacids，Neu5Ac）是人体中最常见的唾液酸。Neu5Ac在人体中普遍存在，在脑组织及母乳中含量较高；唾液酸作用于神经元细胞膜及突触，在神经系统中产生重要作用 ...
卞冬生
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Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 2, June 2025.Abstract Prior disaster experiences often provide lessons for communities to respond to new disasters. In informal communities prone to disasters but conditioned within reactive disaster management regimes, residents and Community‐Based Organizations (CBOs) play immense roles in disaster risk reduction and response.
Stephen Kofi Diko +5 more
wiley +1 more source
Effect of Ba Zhu Decoction(BZD) on the related mechanisms of Aβ formation in 5xFAD transgenic mice [PDF]
, 2016 目的：巴茱合剂是本人硕士导师治疗阿尔兹海默病(AD)的经验方，前期临床研究证明，巴茱合剂能有效缓解AD患者认知功能障碍，但对巴茱合剂的作用机制尚未深入研究。本文旨在通过AD转基因动物再次验证巴茱合剂的治疗效果，并进一步探索巴茱合剂治疗AD的相关分子生物学机制。 方法：（1）选取新型APP/PS1转基因小鼠(5xFAD小鼠)作为实验对象。将3月龄5xFAD小鼠随机分为模型组(5xFAD-Control)、巴茱合剂低剂量组(5xFAD-BZD-L)、中剂量组(5xFAD-BZD-M)、高剂量组(5xFAD ...
彭阿香
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Conceptualizing Organizational Forgetting in a Crisis Context
Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 2, June 2025.ABSTRACT This conceptual article aims to promote research on organizational forgetting in the context of crises. Organizations do not only learn but they also forget: they lose previously acquired knowledge and practices over time. In contrast to a multitude of studies on organizational learning, the concept of organizational forgetting has been ...
Wout Broekema
wiley +1 more source
Toxicity of BaP exposure during embryonic stage in zebrafish: the mechanisms involved [PDF]
, 2016 多环芳烃（PolycyclicAromaticHydrocarbon，PAH）是环境中一类分布广泛的持久性有机污染物。苯并（a）芘（Benzo(a)pyrene，BaP）作为代表性的PAH具有包括神经毒性和生殖毒性在内的多种毒性。截至目前，关于BaP神经毒性的研究大多集中于高浓度或短期的暴露实验，而环境水平浓度下、长期的BaP暴露是否能引起同样的神经毒性则研究得较少；此外，胚胎时期低浓度BaP暴露对成年阶段的神经毒性、生殖毒性效应及其机制研究更为少见。因此本研究以斑马鱼为模式动物，分别进行环境水平浓度 ...
高东旭
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A Multiple‐Choice Exercise on Collocations: What Do Learners Actually Remember?
International Journal of Applied Linguistics, Volume 35, Issue 2, Page 824-833, May 2025.ABSTRACT Contemporary materials for second language (L2) learning feature exercises on collocations (i.e., word partnerships such as catch fire), many of which require learners to select correct word combinations from two or more candidates. A few studies of the effectiveness of these selected‐response exercises, which are essentially multiple‐choice ...
Alyssa Mengxue Li, Frank Boers
wiley +1 more source
The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]
, 2016 细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
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