Results 31 to 40 of about 5,621 (166)

The role and mechanism of hnRNP A2/B1 in breast cancer [PDF]

open access: yes, 2015
核不均一核糖核蛋白A2/B1(hnRNPA2/B1)是hnRNP蛋白家族成员,在肿瘤细胞增殖与凋亡过程中具有重要作用。本实验为了探究hnRNPA2/B1蛋白在乳腺癌组织中的表达及其在乳腺癌细胞中的定位。研究hnRNPA2/B1在乳腺癌细胞中所涉及的主要功能、信号通路以及可变剪接和蛋白融合过程,并探究hnRNPA2/B1对细胞增殖、凋亡、迁移等生物功能的影响。从而阐明hnRNPA2/B1在乳腺癌中的作用机制,为肿瘤的机理研究、临床诊断和治疗提供一个新靶点。本实验用免疫组化方法检测hnRNPA2 ...
韩荣
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Traditional knowledge promotes the protection of large old trees: A case from China's richest biocultural diversity area

open access: yesPeople and Nature, Volume 7, Issue 11, Page 2700-2713, November 2025.
Abstract Large old trees are important ecological entities in human settlements, providing cultural values and ecological services that are threatened by current and future changes in global climate, land use and disturbance regimes. Some studies suggest incorporating social and cultural significance into the conservation of large old trees.
Zhuo Cheng   +5 more
wiley   +1 more source

suPAR在原发性局灶节段性肾小球硬化足细胞损伤的作用

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2023
目的探讨suPAR在原发性FSGS患者足细胞损伤中的作用。方法①收集原发性FSGS患者(17 例)血清,以健康志愿者(10 例)及其他类型原发性肾病综合征患者(10 例)作为正常及疾病对照,采用ELISA检测suPAR水平;②采用suPAR体外刺激足细胞,收集细胞行流式细胞术分析细胞凋亡情况;收集细胞,提取RNA,行RNAseq;③足细胞RNAseq数据差异基因筛选,上下调基因行KEGG及GO通路富集分析,热图展示足细胞局部黏附、滤过膜、细胞骨架及内吞相关基因变化情况,并行qPCR验证 ...
胡浩强   +3 more
doaj  

Study on the Roles of Long Noncoding RNA HCAL in Hepatocellular Carcinoma [PDF]

open access: yes, 2016
【背景】 原发性肝癌是最常见的恶性肿瘤之一,是我国发病率和死亡率均排名第二的恶性肿瘤。原发性肝癌中,大部分为肝细胞肝癌(简称肝癌)。虽然肝癌的诊断及手术切除、放化疗等治疗手段取得了很大的进步,但肝癌患者总体的生存率仍不理想。近年来,对肝癌的分子生物学机制进行了多方面的研究,并证实肝癌的发生发展伴随着一系列分子表达的失调及信号通路的异常。因此,从分子水平深入探讨肝癌发生发展及转移的机制,对寻找早期诊断、预测预后的生物标志物和治疗的分子靶点具有重要的临床意义。 长链非编码RNA ...
谢程融
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Institutional Legacies and Governance Models: A Comparative Study of Broadband State Aid in Europe

open access: yesPolitics &Policy, Volume 53, Issue 5, October 2025.
ABSTRACT This article explores how historical legacies and institutional configurations impact the governance models used in implementing State aid policies for broadband in France, Portugal, Spain, and the United Kingdom. The analysis is based on historical institutionalism, focusing on path dependence, critical junctures, and gradual institutional ...
Luís Manica   +2 more
wiley   +1 more source

Studies on Genes Related to Copper Accumulation of the Fujian Oyster Crassostrea angulata [PDF]

open access: yes, 2015
牡蛎是具有重要经济价值的海水养殖品种,在世界很多地区都有养殖。而我国牡蛎养殖产量居世界首位。同时,牡蛎对铜、锌等金属具有很强的富集能力,经常被用于指示河口污染情况。随着工业发展,近岸河口区遭受越来越严重的金属污染,铜就是其中非常有代表性的金属污染物。因此牡蛎对铜的超富集现象越来越被人们所关注。学者们发现牡蛎对铜富集存在非常大的个体差异,然而相关的研究却非常有限,特别是缺少分子机制的解析。对这一现象的深入研究不但可以探寻、丰富牡蛎铜富集相关机制,更可以为选育牡蛎不同金属富集能力品系提供理论依据 ...
史博
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Transcriptomics-based Exploration of the Effects of Oviductus Ranae on Rats with Impaired Follicular Development [PDF]

open access: yes
Objective: The effects of Oviductus Ranae (OR) on cyclophosphamide-induced follicular developmental disorders were analyzed from the perspective of transcriptomics, which provided sufficient theoretical and experimental basis for the study of estrogen ...
Fengqing ZHANG   +7 more
core   +1 more source

Generalist predators function as pest specialists: Examining diet composition of spiders and ladybeetles across rice crop stages

open access: yesJournal of Applied Ecology, Volume 62, Issue 8, Page 1889-1901, August 2025.
By quantifying the diet composition of GAPs over crop stages, farm types and years, this study reveals that generalist predators have potential to produce a stable, predictable top‐down effect on pests in rice agro‐ecosystems. Therefore, promoting the field densities of ubiquitous generalist predators will likely enhance pest management and support ...
Gen‐Chang Hsu   +4 more
wiley   +1 more source

喀斯特坡地侵蚀泥沙养分流失与粒径分布的关系

open access: yesShuitu Baochi Xuebao, 2019
在丹江口库区喀斯特地区,研究分析自然降雨条件下5种不同植被覆盖类型(疏林地(C1)、乔木林地(C2)、坡耕地(C3)、荒草地(C4)、灌草地(C5))坡面侵蚀泥沙的氮、磷、钾养分流失及泥沙粒径分布特征,探讨泥沙养分流失与粒径分布的关系。结果表明:(1)侵蚀泥沙以粉粒(2~50 μm)、砂粒(50~2 000 μm)为主,0~20 μm颗粒含量随降雨强度的增加而减少。0~2 μm颗粒富集度集中在3.08~6.62,2~20 μm颗粒富集度集中在2.48~3.58,20~2 000 ...
周梦玲   +6 more
doaj  

The Role of Messenger RNA Alternative Polyadenylation During Developmental Gene Expression Regulation and Adapdation of Rice [PDF]

open access: yes, 2016
水稻(Oryzasativa)不仅是世界上最重要的粮食作物之一,也是单子叶模式植物。水稻品种japonicaNipponbare和indica93-11为两个水稻亚种代表,广泛的种植于我国的南北区域,对环境与气候形成一定的适应性,在我国形成北粳南籼的生产格局。它们各自具有独自的生理特性和生长周期。转录组为特定生理条件下,细胞中全部转录产物的集合。通过对水稻发育过程转录组的研究,可以全面地了解基因表达调控在水稻发育过程中的调节作用以及对环境适应性。多聚腺苷化是基因在转录形成成熟的转录本之前的加工过程之一 ...
付海辉
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