Research Progress on Mechanism of NAD+ Metabolic Remodeling in Occurrence and Development of Glioblastoma Multiforme [PDF]
Gliomas, especially high-grade gliomas such as glioblastoma multiforme (GBM), are primary malignant tumors of the central nervous system, characterized by high proliferative capacity, invasiveness, and therapeutic resistance.
Chengwen WANG +6 more
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The functional characteristics of GPR120 and its mechanism in preventing atherosclerosis [PDF]
Free fatty acids are important substances for regulating energy metabolism in the body and mainly exert their functions by binding to G protein-coupled receptors（GPRs）on the cell membrane. GPR120 is the receptor for medium and long-chain free fatty acids
XIAO Jiahai, CHEN Gengji, ZHANG Pengfei, WU Tianyu, CHEN Xiaojia, ZHANG Zhizhen
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Biological activity and food application of carboxymethyl pachymaran [PDF]
Carboxymethyl pachymaran （CMP） is a carboxymethylated modification product of the water-insoluble polysaccharides from Poria cocos. It has many biological activities such as immune regulation, antibacterial, anti-inflammatory, anti-tumor, anti-oxidation,
DAI Xinwen +4 more
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Research progress on low-intensity pulsed ultrasound in promoting osseointegration of dental implants [PDF]
How to effectively promote osseointegration of dental implants remains a pressing clinical challenge. Low-intensity pulsed ultrasound (LIPUS) has demonstrated remarkable efficacy in accelerating the healing of various bodily tissues, including bone ...
ZHANG Xinyu, QU Fang, XU Chun
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Research progress of the immunosuppressive tumor microenvironment in multiple myeloma [PDF]
Multiple myeloma (MM) is a hematological malignancy originating from the immune system, and the immune microenvironment plays a pivotal role in its pathogenesis and progression.
Peng LIU, Yue WANG
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Dectin-1通过巨噬细胞极化影响STEMI的机制研究 附视频
Zhongguo shiyan zhenduanxue目的 探究Dectin-1通过巨噬细胞极化影响STEMI的机制研究。方法 将45只SPF级SD大鼠随机分为假手术组(n=15)、模型组(n=15)、si-Dectin-1组(n=15),模型组与si-Dectin-1组分别通过尾静脉注射NC-质粒和si-Dectin质粒，2周后建立ST段抬高型心肌梗死(ST-Segment Elevation Myocardial Infarction, STEMI)模型，2周后分离心脏组织，qPCR检测心脏组织Dectin-1表达水平，TTC染色检测心肌坏死面积 ...
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Research progress on the effect of type 2 diabetes and hypoglycemic drugs on the prognosis of patients with colorectal cancer [PDF]
In recent years，the comorbidity of CRC and DM has become more and more common，and has become one of the public health problems that seriously endanger human health.
ZHANG Meng，LEI Xuefen，CHEN Haixia，CHEN Yixuan，JIANG Li
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[Regulatory mechanism of deferoxamine on macrophage polarization and wound healing in mice with deep tissue injury]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2022 Shan H +4 more
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[Oral Squamous Cell Carcinoma-Derived Cell-Free DNA Modulates Stemness and Migration of Oral Squamous Cell Carcinoma Cell Line by Inducing M2 Macrophage Polarization]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Zheng SZ +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban巨噬细胞作为心脏固有免疫系统的关键细胞，具有高度异质性和可塑性，在心脏生理和病理进程中发挥双重作用。近年，巨噬细胞源性外泌体作为细胞间通讯的重要介质，在心脏疾病中的调控机制及潜在治疗应用备受关注。本文系统总结心脏常驻巨噬细胞的起源、分布和功能，探讨M1和M2型巨噬细胞在心脏炎症反应和组织修复中的作用，以及巨噬细胞外泌体在心脏疾病中的调控机制和治疗应用前景。在心脏损伤急性阶段，M1型巨噬细胞通过分泌促炎细胞因子等引发炎症，清除细胞碎片，但过度激活会导致心肌细胞损伤和纤维化；恢复阶段，M2型巨噬细胞主导 ...
谭云科, 杨正飞
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