Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]
Cell Reports, 2017 The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose ...
Angela Castoldi +2 more
exaly +9 more sources
Role of Dectin-1 in peripheral nerve injury [PDF]
Frontiers in Cellular Neuroscience, 2022 Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood.
Angela Yu-Huey Hsu +5 more
doaj +4 more sources
CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway. [PDF]
PLoS Pathogens, 2015 Collaboration between heterogeneous pattern recognition receptors (PRRs) leading to synergistic coordination of immune response is important for the host to fight against invading pathogens.
Juin-Hua Huang +7 more
doaj +26 more sources
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis [PDF]
Cellular and Molecular Immunology, 2012 We thank Dr. Cristina Massi Benedetti for digital art and editingRecognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses.
Agostinho Carvalho +2 more
exaly +2 more sources
TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes [PDF]
Journal of Translational MedicineBackground Dectin-1, a key innate immune receptor, plays a critical role in cellular responses and is implicated in chronic inflammation and metabolic syndromes.
Ashraf Al Madhoun +8 more
doaj +2 more sources
IL-6 regulates the polarization of Dectin-1 macrophages to weaken immune escape in thyroid cancer [PDF]
Journal of Translational MedicineBackground Immune evasion is a critical barrier to effective treatment of thyroid carcinoma (TC). Macrophage polarization plays a pivotal role in shaping the tumor microenvironment (TME). This study aimed to elucidate how IL-6 regulates Dectin-1–mediated
Xianzhao Deng +5 more
doaj +2 more sources
Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS [PDF]
HeliyonMicroglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly upregulated in a specific microglial response state called disease-associated ...
Justin You +9 more
doaj +2 more sources
Cells, 2022 In obesity, macrophage activation and infiltration in adipose tissue (AT) underlie chronic low-grade inflammation-induced insulin resistance. Although dectin-1 is primarily a pathogen recognition receptor and innate immune response modulator, its role in
Ashraf Al Madhoun +7 more
doaj +1 more source
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
doaj +1 more source
Microbiome, 2022 Background Innate immunity genes have been reported to affect susceptibility to inflammatory bowel diseases (IBDs) and colitis in mice. Dectin-1, a receptor for fungal cell wall β-glucans, has been clearly implicated in gut microbiota modulation and ...
Yazhou Wang +11 more
doaj +1 more source