Results 41 to 50 of about 18,918 (210)

Internalization of Dectin‐1 terminates induction of inflammatory responses [PDF]

European Journal of Immunology, 2009
AbstractDectin‐1 is a pattern‐recognition receptor recognizing β‐(1,3)‐glucans found on fungal cell walls. Dectin‐1 plays an important role in immunity to fungi by mediating phagocytic clearance of fungal particles and inducing transcription of innate response genes.
Hernanz-Falcón, Patricia, Joffre, Olivier, Williams, David L., Reis e Sousa, Caetano   +3 more
openaire   +3 more sources

1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells.

PLoS ONE, 2016
BackgroundThe objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A.
Yiping Xia, Guiqiu Zhao, Jing Lin, Cui Li, Lin Cong, Nan Jiang, Qiang Xu, Qian Wang   +7 more
doaj   +1 more source

Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo

BMC Oral Health, 2022
Background Toll like receptors (TLR) 2 and 4 present on innate immune cells of the dental pulp detect cariogenic bacteria. Along with bacteria, C. albicans may also be present in dental caries. The presence of C.
Arshad Hasan, Talat Roome, Mohsin Wahid, Shazia Akbar Ansari, Hira Akhtar, Syeda Neha Ahmed Jilani, Amber Kiyani   +6 more
doaj   +1 more source

Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]

, 2020
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik, Bossier, Peter, Cox, Eric, Han, Biao, Vanrompay, Daisy   +4 more
core   +2 more sources

FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells

Frontiers in Immunology, 2017
The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcεRI γ-chain (FcRγ) has been found in many immune functions.
Yi-Gen Pan, Yen-Ling Yu, Chi-Chien Lin, Lewis L. Lanier, Lewis L. Lanier, Ching-Liang Chu   +5 more
doaj   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source

Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst [PDF]

, 2014
Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of ...
Chan, Rebecca J., Feng, Gen-Sheng, Goodwin, Charles B., Hanenberg, Helmut, Li, Xing Jun, Matozaki, Takashi, Nabinger, Sarah C., Ohnishi, Hiroshi, Richine, Briana M., Yang, Zhenyun   +9 more
core   +2 more sources

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.

PLoS ONE, 2009
BackgroundDectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall.
Hilbert S de Vries, Theo S Plantinga, J Han van Krieken, Rinke Stienstra, Ad A van Bodegraven, Eleonora A M Festen, Rinse K Weersma, J Bart A Crusius, Ronald K Linskens, Leo A B Joosten, Mihai G Netea, Dirk J de Jong   +11 more
doaj   +1 more source

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis

The Journal of Clinical Investigation, 2022
Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S.P. Viall, Christa S. Zerbe, Elise M.N. Ferré, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis   +58 more
doaj   +1 more source

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections [PDF]

New England Journal of Medicine, 2009
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
Ferwerda, E.B., Ferwerda, G., Plantinga, T.S., Willment, J.A., van Spriel, A.B., Venselaar, H., Elbers, C.C., Johnson, M.D., Cambi, A., Huysamen, C., Jacobs, L., Jansen, T.J.G., Verheijen, K., Masthoff, L., Morre, S.A., Vriend, G., Williams, D.L., Perfect, J.R., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., Wijmenga, C., van der Meer, J.W.M., Adema, G.J., Kullberg, B.J., Brown, G.D., Netea, M.G.   +26 more
openaire   +7 more sources