Results 41 to 50 of about 21,245,874 (166)
Dectin-2 recognizes endogenous molecule(s) on BMDCs.
, 2017 (A-D) Dectin-2 recognized molecules derived from BMDCs. (A) Reporter cells expressing Dectin-2 together with FcRγ were incubated with or without BMDCs or BMDMs for 18 h.
Kensuke Shibata (3612512) +2 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat +5 more
wiley +1 more source
Data_Sheet_1_Role of Dectin-1 in peripheral nerve injury.PDF
, 2022 Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood.
Angela Yu-Huey Hsu (13166040) +1 more
core +1 more source
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, Accepted Article.Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source
Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens
Cell Proliferation, EarlyView.In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu +8 more
wiley +1 more source
, 2017 C57BL/6 (WT) and Dectin-3 KO mice were given an intranasal inoculation with C. neoformans strain H99 (serotype A). Mice were observed up to Day 41 for survival (A) and pulmonary fungal burden (B) was analyzed at days 7 and 14 post-inoculation ...
Karen L. Wozniak (229721) +4 more
core +1 more source
Characterization of rat β‐glucan receptor dectin‐1 [PDF]
Microbiology and Immunology, 2008 ABSTRACTDectin‐1 is a small C‐type lectin receptor for fungal cell wall β‐glucan. Its homologues in some species, including mouse and human, have been characterized, and their importance in antifungal immunity has also been clarified. However, its homologue in the rat has not yet been identified.
Yuya, Kato +2 more
openaire +2 more sources
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source