Results 31 to 40 of about 18,918 (210)
Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]
, 2016 AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke +50 more
core +1 more source
Frontiers in Immunology, 2018 We recently discovered that dectin-1-activated dendritic cells (DCs) drive potent T helper (Th) 9 cell responses and antitumor immunity. However, the underlying mechanisms need to be further defined.
Jintong Chen +11 more
doaj +1 more source
Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]
, 2018 This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R +5 more
core +1 more source
Dectin-1 Is A Major β-Glucan Receptor On Macrophages [PDF]
The Journal of Experimental Medicine, 2002 Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and complement receptor 3 (CR3) have historically been considered the major macrophage lectins involved in the nonopsonic recognition of these yeast-derived ...
Brown, Gordon D. +7 more
openaire +5 more sources
mBio, 2014 The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface
Kerstin A. Heyl +9 more
doaj +1 more source
Duality of β-glucan microparticles: antigen carrier and immunostimulants [PDF]
, 2016 Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper
Baert, Kim +4 more
core +2 more sources
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.
PLoS ONE, 2012 The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz +8 more
doaj +1 more source
RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]
, 2017 Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L +4 more
core +2 more sources
Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
BMC Gastroenterology, 2012 Background It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome.
Heinsbroek Sigrid EM +6 more
doaj +1 more source
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent. [PDF]
, 2012 PURPOSE: This study is aimed at demonstrating the in vivo potential of Gd(III)-loaded glucan particles (Gd-GPs) as magnetic resonance imaging (MRI)-positive agents for labeling and tracking phagocytic cells.
Aime, Silvio +7 more
core +1 more source