Results 31 to 40 of about 21,245,874 (166)

Dectin-1/2–induced autocrine PGE₂ signaling licenses dendritic cells to prime Th2 responses [PDF]

, 2018
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which
Schramm, Gabriele, Martin Giera, da Costa, Clarissa Prazeres, Gabriele Schramm (703015), Maria M M Kaisar, Laura E. Layland (173877), David Sancho, Kaiser, Maria M. M., Ritter, Manuel, Leyland, L.E., Bart Everts, Jonesdottir, Hulda S., David Sancho (5117801), Giere, Martin, Laura E Layland, Schramm, G., Kaiser, M.M.M., Manuel Ritter, Maria Yazdanbakhsh, Leonard R. Pelgrom, Carlos del Fresno (336568), Hulda S Jónasdóttir, Leonard R Pelgrom, Bart Everts (125289), Sancho, David, Maria M. M. Kaisar (287175), Clarissa Prazeres da Costa, Leonard R. Pelgrom (5117807), Clarissa Prazeres da Costa (104701), Costa, C.P. da, Jonesdottir, H.S., Carlos Del Fresno, Martin Giera (1598620), Gabriele Schramm, Everts, B., Hulda S. Jónasdóttir (5117804), Leyland, Laura E., Ham, A.J. van der, Pelgrom, L.R., Giere, M., Maria M. M. Kaisar, Ritter, M., Alwin J. van der Ham (554013), Yazdanbakhsh, Maria, van der Ham, Alwin J., Maria Yazdanbakhsh (90295), Laura E. Layland, Yazdanbakhsh, M., Alwin J. van der Ham, Pelgrom, Leonard R., Fresno, C. del, Manuel Ritter (104679), Sancho, D., Everts, Bart, Hulda S. Jónasdóttir, Alwin J van der Ham, del Fresno, Carlos   +56 more
core   +1 more source

Dectin-2 binds to Gusb.

, 2017
(A and B) Identification of Dectin-2-binding molecules on BMDCs. Affinity-purified proteins using Ig, Dectin-2QPD-Ig (QPD) and Dectin-2-Ig (WT) were eluted with (A) heating or (B) addition of elution buffer containing 100mM Mannose.
Kensuke Shibata (3612512), Sho Yamasaki (522606), Daiki Mori (3612515)   +2 more
core   +1 more source

Dectin-1 Exerts Dual Control in the Gut [PDF]

Cell Host & Microbe, 2015
Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.
openaire   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Dectin-1 alone is not sufficient to bind C. neoformans spores.

, 2017
CHO-K1 cells were engineered to express murine Dectin-1 (Clec-7a) with a C-terminal HA tag. Dectin-1-HA protein expression and localization were verified with an antibody directed against HA and conjugated to Cy3 (red).
Naomi M. Walsh (3830494), Marcel Wuthrich (3830491), Christina M. Hull (366731), Huafeng Wang (2304877), Bruce Klein (432955)   +4 more
core   +1 more source

Human Dectin-1 Deficiency Impairs Macrophage-Mediated Defense Against Phaeohyphomycosis

, 2022
Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis
Simon Vautier, Zelazny, Adrian M., Zerbe, Christa S., Butman, John A., Katrin D. Mayer-Barber, Bennett, John E., Nicholas S.P. Viall, Lawrence C. Kenyon, Rodrigo Hasbun, Drummond, Rebecca A.; id_orcid, Holland, Steven M., Brian Driscoll, John E. Bennett, Oikonomou, Vasileios, Oler, Andrew J., Mahmood, Maryam, Muthulekha Swamydas, David Bianchi, Matthew Sincock, Lim, Jean K., Lionakis, Michail S., Amy P. Hsu, Vasileios Oikonomou, Yoichiro Iwakura, Drummond, Rebecca A., Acklin, Joshua A., Yamanaka, Daisuke, Rebecca A. Drummond, Maryam Mahmood, Gordon D. Brown, Vinh, Donald C., Adrian M. Zelazny, Kenyon, Lawrence C., Vautier, Simon, Bianchi, David, Swamydas, Muthulekha, Natarajan, Mukil, Abers, Michael S., DiMaggio, Tom, Kyung J. Kwon-Chung, Whitener, Cindy J., Freeman, Alexandra F., Hauck, Ken, Kline, Ahnika, Michail S. Lionakis, Anzick, Sarah L., Desai, Jigar V., Rao, Ganesh, Kelly, Sean G., Ahnika Kline, Magdalena A. Walkiewicz, William R. Miller, Pittaluga, Stefania, Ken Hauck, Daisuke Yamanaka, Miller, William R., Kuhns, Douglas B., Yvonne R. Shea, Mukil Natarajan, Shea, Yvonne R., Walkiewicz, Magdalena A., Jean K. Lim, Mikelis, Constantinos M., Katia Boggian, John A. Butman, Alexandra F. Freeman, Iwakura, Yoichiro, Hsu, Amy P., Steven M. Holland, Bloch, Karen C., Zelalem Temesgen, Karen C. Bloch, Ferré, Elise M.N., Sarah L. Anzick, Stefania Pittaluga, Ashbaugh, Cameron, Hasbun, Rodrigo, Cameron Ashbaugh, Sean G. Kelly, Christa S. Zerbe, Kwon-Chung, Kyung J., Monica M. Schmitt, Mayer-Barber, Katrin D., Viall, Nicholas S.P., Cesar A. Arias, Juan Gea-Banacloche, Varsha Moudgal, Joshua A. Acklin, Tom DiMaggio, Donald C. Vinh, M. Suzanne Whitworth, Andrea Gilbert, Brown, Gordon D., Ganesh Rao, Mafi, Neema, Elise M.N. Ferré, Arias, Cesar A., Douglas B. Kuhns, Sincock, Matthew, Alexander G. Theofiles, Nigo, Masayuki, Whitworth, M. Suzanne, Boggian, Katia, Temesgen, Zelalem, Belkaid, Yasmine, Theofiles, Alexander G., Constantinos M. Mikelis, Driscoll, Brian, Andrew J. Oler, Schmitt, Monica M., Yasmine Belkaid, Jigar V. Desai, Moudgal, Varsha, Gea-Banacloche, Juan, Gilbert, Andrea, Cindy J. Whitener, Michael S. Abers, Masayuki Nigo, Neema Mafi   +118 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Dectin-1^-/- and Dectin-2^-/- phagocytes show modest changes in internalization of C. neoformans spores.

, 2017
Flow cytometry was used to differentiate and assess internalization and binding of C. neoformans spores by DC-enriched bone marrow-derived phagocytes and AMs. (A) Results of flow cytometry analysis using DC-enriched phagocytes shown as FACS plots and (B)
Naomi M. Walsh (3830494), Marcel Wuthrich (3830491), Christina M. Hull (366731), Huafeng Wang (2304877), Bruce Klein (432955)   +4 more
core   +1 more source

Dectin-1 Mediates the Biological Effects of β-Glucans [PDF]

The Journal of Experimental Medicine, 2003
The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized phenomenon. Although efforts have been made to understand how these carbohydrate polymers exert their immunomodulatory effects, the receptors involved in generating ...
Brown, Gordon D., Herre, Jurgen, Williams, David L., Willment, Janet A., Marshall, Andrew S.J., Gordon, Siamon   +5 more
openaire   +4 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source