Results 51 to 60 of about 18,918 (210)

Dectin-1 as a therapeutic target for inflammatory bowel disease. [PDF]

Adv Pharmacol
Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the distal gastrointestinal tract, including Crohn's disease and ulcerative colitis. This chapter explores the potential of Dendritic cell-associated C-type lectin-1 (Dectin-1), a pattern recognition receptor, as a therapeutic target for IBD.
Li Y, Huang M, Cardinale S, Su Y, Peters DE, Slusher BS, Zhu X.   +6 more
europepmc   +3 more sources

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression [PDF]

, 2017
One of the major life-threatening infections for which severely immunocompromised patients are at risk is invasive aspergillosis (IA). Despite the current treatment options, the increasing antifungal resistance and poor outcome highlight the need for ...
Antachopoulos, Armstrong-James, Becker, Bellocchio, Bellocchio, Ben-Ami, Ben-Ami, Berrington, Bonnett, Bozza, Brock, Brown, Chai, Chamaillard, Chamilos, Chamilos, Chung, Cunha, Cunha, Drummond, Dubourdeau, Frutuoso, Galiger, Gantner, Gersuk, Gessner, Girardin, Gresnigt, Gresnigt, Gresnigt, Grube, Hohl, Joosten, Juarez, Kanayama, Kroll, Kyrmizi, Lamoth, Luther, Mehrad, Mencacci, Netea, Netea, Oosting, Opitz, Phadke, Philippe, Rodland, Said-Sadier, Sainz, Segal, Shepardson, Sprenkeler, Steele, Su, Tam, Underhill, Watanabe, Werner, Zhang   +59 more
core   +4 more sources

Dectin-1 Exerts Dual Control in the Gut [PDF]

Cell Host & Microbe, 2015
Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.
openaire   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors [PDF]

, 2014
Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune ...
Gow, Neil A R, Ifrim, Daniela C, Jacobs, Cor, Jacobs, Liesbeth, Jansen, Trees, Joosten, Leo A B, Netea, Mihai G, Quintin, Jessica, van der Meer, Jos W M, Williams, David L   +9 more
core   +8 more sources

Dectin‐1 promotes fungicidal activity of human neutrophils [PDF]

European Journal of Immunology, 2007
AbstractHuman polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease.
Kennedy, Adam D., Willment, Janet A., Dorward, David W., Williams, David L., Brown, Gordon D., DeLeo, Frank R.   +5 more
openaire   +3 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Co-regulation of Dectin-1 and TLR2 in inflammatory response of human corneal epithelial cells induced by Aspergillus fumigates [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the co-regulation of dendritic cell-associated C-type lectin-1 (Dectin-1), Toll-like receptor 2 (TLR2), and relative chemotactic factors in the Telomease-immortalized human corneal epithelial (THCE) cells after exposure to Aspergillus
Gui-Qiu Zhao, Xue-Yan Qiu, Jing Lin, Qing Li, Li-Ting Hu, Qian Wang, Hui Li   +6 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Dectin-1 Mediates the Biological Effects of β-Glucans [PDF]

The Journal of Experimental Medicine, 2003
The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized phenomenon. Although efforts have been made to understand how these carbohydrate polymers exert their immunomodulatory effects, the receptors involved in generating ...
Brown, Gordon D., Herre, Jurgen, Williams, David L., Willment, Janet A., Marshall, Andrew S.J., Gordon, Siamon   +5 more
openaire   +4 more sources