Results 61 to 70 of about 21,245,874 (166)

RHOA mediated mechanical force generation through Dectin-1 [PDF]

Journal of Cell Science, 2019
ABSTRACT Dectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on the Candida albicans ( C. albicans ) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine ...
Choraghe, Rohan P., Kołodziej, Tomasz, Buser, Alan, Rajfur, Zenon, Neumann, Aaron K.   +4 more
openaire   +4 more sources

Harnessing Gut Microbiota to Enhance Immunotherapy in NSCLC: From Mechanisms to Translational Applications

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT The gut microbiome has emerged as a pivotal regulator of immunotherapy efficacy in non‐small cell lung cancer (NSCLC), with mounting evidence demonstrating that microbial‐immune crosstalk significantly influences therapeutic responses. Current research reveals that commensal bacteria modulate host immunity through complex metabolic and ...
Liming Zhu, Jiayao Xu, Dong Niu, Xiangyu Zhang, Chunhui Jin   +4 more
wiley   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Fungal‐Bacterial Interactions in Polymicrobial Infections: Hidden Threats

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
ABSTRACT Polymicrobial infections involving fungi and bacteria represent a major and increasingly recognized clinical challenge, in which interkingdom interactions significantly amplify disease severity, antimicrobial resistance, and treatment failure. Rather than passive co‐existence, fungal–bacterial communities form highly coordinated systems driven
Mohammad Javad Roustaye Gourabi, Masoud Kargar, Atefeh Kamali, Javad Yasbolaghi Sharahi   +3 more
wiley   +1 more source

Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins

, 2010
Tetraspanins are a superfamily of glycoproteins that function as ‘organisers’ of membranes by clustering with each other to form tetraspanin-enriched microdomains, into which certain other receptors and signalling proteins are recruited and regulated ...
Tomlinson, Neil David
core  

Image_2_Dependence on Dectin-1 Varies With Multiple Candida Species.JPEG

, 2019
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs).
Louise Walker (108683), Diogo M. da Fonseca (6883541), Aiysha Thompson (2622574), Selinda J. Orr (7137752), James S. Griffiths (6883544), Keunsook K. Lee (4040492), Neil A. R. Gow (6982910), Philip R. Taylor (7137749)   +7 more
core   +1 more source

Image_3_Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling.JPEG

, 2020
Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events such as
Jan Van den Bossche (7571246), Wouter J. de Jonge (7571258), Kyra E. de Goede (8647809), Sanne G. S. Verberk (8647812), Reina E. Mebius (3373049), Martje N. Erkelens (8115689), Marieke R. Beijer (8647806), Tanja Konijn (3373055), Rosalie Molenaar (8647803), Joke M. M. den Haan (7500083), Gera Goverse (5264510)   +10 more
core   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

Expression of functionally different dectin-1 isoforms by murine macrophages. [PDF]

, 2006
Dectin-1 is a specific receptor for beta-glucans and a major receptor for fungal particles on macrophages (Mphi). It is a type II membrane receptor that has a C-terminal, NK-like, C-type lectin-like domain separated from the cell membrane by a short ...
Willment, Janet A., Taylor, Philip R., Taylor, PR, Williams, DL, Heinsbroek, Sigrid, Heinsbroek, Sigrid E. M., Rosas, Marcela, Rosas, M, Brown, Gordon D., Williams, David L., Gordon, S, Willment, JA, Heinsbroek, SE, Brown, GD, Gordon, Siamon   +14 more
core   +1 more source