Results 81 to 90 of about 18,918 (210)

Mechanisms of Fc Receptor and Dectin‐1 Activation for Phagocytosis [PDF]

Traffic, 2012
Phagocytosis is a key cellular process, both during homeostasis and upon infection or tissue damage. Receptors on the surface of professional phagocytic cells bind to target particles either directly or through opsonizing ligands, and trigger actin‐mediated ingestion of the particles. The process must be carefully controlled to ensure that phagocytosis
Helen S, Goodridge, David M, Underhill, Nicolas, Touret   +2 more
openaire   +2 more sources

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses.

PLoS ONE, 2016
PurposeTo explore the possibility that inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and Dendritic cell-associated C-type lectin-1(Dectin-1) could modulate the innate immune response and alleviate the severity of corneal fungal ...
Jing Zhong, Weilan Huang, Qiuchan Deng, Minhao Wu, Huaili Jiang, Xiaolei Lin, Yifang Sun, Xi Huang, Jin Yuan   +8 more
doaj   +1 more source

Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells [PDF]

, 2014
Various polysaccharides purified from plants are considered to be biological response modifiers and have been shown to enhance immune responses. Ficus carica L. is a Chinese traditional plant and has been widely used in Asian countries for its anti-tumor
Chen, J, Lu, L, Ma, J, Rui, K, Tang, X, Tian, J, Wang, S, Xu, H, Yang, X, Zhang, Y   +9 more
core   +2 more sources

Dectin‐1 mediates zymosan responses in microglia

The FASEB Journal, 2007
Microglia are the major immune component of brain that play a central role in neuroinflammation. Microglia are normally quiescent but are rapidly activated in response to pathogens as well as physical, chemical, or ischemic injuries. Zymosan, a β‐glucan‐containing particle derived from yeast cell wall, is commonly used to activate microglia in ...
Vaibhav Shah, Yongcheng Huang, Lakhu Keshvara   +2 more
openaire   +1 more source

Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian   +6 more
wiley   +1 more source

Biomolecular Corona Remodelling of Aspergillus fumigatus Extracellular Vesicles Shapes Immune Recognition and Macrophage Activation Programs

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Extracellular vesicles (EVs) released by Aspergillus fumigatus play key roles in fungal–host communication. Similar to synthetic nanoparticles, fungal EVs acquire a biomolecular corona composed of a tightly bound “hard” corona layer of fungal proteins and a dynamic “soft” layer of host‐derived molecules adsorbed upon contact with biological ...
Lucas Fabrício Bahia Nogueira, Bianca T. M. de Oliveira, Renan E. A. Piraine, Lucas de Faria Nogueira, Júlia L. Froldi, Henrique T. de Oliveira, Larwsk Hayann, Luiz H. S. Andrilli, Lucas A. Tavares, Pietro Ciancaglini, Fausto Almeida   +10 more
wiley   +1 more source

Intestinal fungi contribute to development of alcoholic liver disease [PDF]

, 2017
This study was supported in part by NIH grants R01 AA020703, U01 AA021856 and by Award Number I01BX002213 from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (to B.S.). K.H.
Ali Keshavarzian, An-Ming Yang, Bernd Schnabl, Bode, Chien-Sheng Chen, Claus Hellerbrand, Cristina Llorente, Derrick E. Fouts, Ece A. Mutlu, Fettweis, Fouts, Gordon D. Brown, Guadalupe Garcia-Tsao, Hal M. Hoffman, Jun Xu, Karen Beeri, Katrin Hochrath, Kelvin Moncera, Kim Freese, Lee, Lirui Wang, Liu, Manolito G. Torralba, Peng Chen, Peter Stärkel, Phillipp Hartmann, Ramon Bataller, Samuel B. Ho, Sena Bluemel, Serene M.L. Lee, Sokol, Tatiana Kisseleva, Tatsuo Inamine, Wagner, Wajahat Z. Mehal, Yamahiro, Yang, Yukinori Koyama   +37 more
core   +3 more sources

RHOA mediated mechanical force generation through Dectin-1 [PDF]

Journal of Cell Science, 2019
ABSTRACT Dectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on the Candida albicans ( C. albicans ) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine ...
Choraghe, Rohan P., Kołodziej, Tomasz, Buser, Alan, Rajfur, Zenon, Neumann, Aaron K.   +4 more
openaire   +4 more sources

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source