Results 11 to 20 of about 21,245,874 (166)

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. [PDF]

Sci Adv, 2023
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable expressivity are characteristic of IDAIL caused by CTLA-4 haploinsufficiency ...
Turnbull C, Bones J, Stanley M, Medhavy A, Wang H, Lorenzo AMD, Cappello J, Shanmuganandam S, Pandey A, Seneviratne S, Brown GJ, Meng X, Fulcher D, Burgio G, Man SM, de Lucas Collantes C, Gasior M, López Granados E, Martin P, Jiang SH, Cook MC, Ellyard JI, Athanasopoulos V, Corry B, Canete PF, Vinuesa CG.   +25 more
europepmc   +12 more sources

Role of Dectin-1 in peripheral nerve injury. [PDF]

Front Cell Neurosci, 2022
Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages.
Hsu AY, Hsieh ST.
europepmc   +6 more sources

Dectin-1-Independent Macrophage Phagocytosis of <i>Mycobacterium abscessus</i>. [PDF]

Int J Mol Sci, 2023
Mycobacterium abscessus, a species of nontuberculous mycobacteria (NTM), is an opportunistic pathogen that is readily cleared by healthy lungs but can cause pulmonary infections in people with chronic airway diseases. Although knowledge pertaining to molecular mechanisms of host defense against NTM is increasing, macrophage receptors that recognize M ...
Ochoa AE, Congel JH, Corley JM, Janssen WJ, Nick JA, Malcolm KC, Hisert KB.   +6 more
europepmc   +4 more sources

Dectin-1

, 2004
In host defence, pattern recognition plays an essential role by enabling the immune system to discriminate self from pathogenic non-self. Pattern recognition is mediated by leukocyte expressed pattern recognition molecules (PRMs), which recognise pathogen associated molecular patterns (PAMPs) on pathogens.
Herre, Jürgen., Herre, Jürgen
core   +5 more sources

The role of dectin-1 in health and disease

Immunobiology, 2021
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). This CLR identifies ligands independently of Ca2+ and is majorly involved in coupling of innate with adaptive immunity. Formerly, Dectin-1 was best known for
Namarta Kalia, Jatinder Singh, Manpreet Kaur   +2 more
exaly   +3 more sources

Dependence on Dectin-1 Varies With Multiple Candida Species [PDF]

Frontiers in Microbiology, 2019
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C.
Aiysha Thompson, Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr   +10 more
core   +9 more sources

Internalization of Dectin‐1 terminates induction of inflammatory responses [PDF]

European Journal of Immunology, 2009
AbstractDectin‐1 is a pattern‐recognition receptor recognizing β‐(1,3)‐glucans found on fungal cell walls. Dectin‐1 plays an important role in immunity to fungi by mediating phagocytic clearance of fungal particles and inducing transcription of innate response genes.
Hernanz-Falcón, Patricia, Joffre, Olivier, Williams, David L., Reis e Sousa, Caetano   +3 more
openaire   +4 more sources

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections [PDF]

New England Journal of Medicine, 2009
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
Ferwerda, E.B., Ferwerda, G., Plantinga, T.S., Willment, J.A., van Spriel, A.B., Venselaar, H., Elbers, C.C., Johnson, M.D., Cambi, A., Huysamen, C., Jacobs, L., Jansen, T.J.G., Verheijen, K., Masthoff, L., Morre, S.A., Vriend, G., Williams, D.L., Perfect, J.R., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., Wijmenga, C., van der Meer, J.W.M., Adema, G.J., Kullberg, B.J., Brown, G.D., Netea, M.G.   +26 more
openaire   +9 more sources

Dectin‐1 promotes fungicidal activity of human neutrophils [PDF]

European Journal of Immunology, 2007
AbstractHuman polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease.
Kennedy, Adam D., Willment, Janet A., Dorward, David W., Williams, David L., Brown, Gordon D., DeLeo, Frank R.   +5 more
openaire   +4 more sources

Dectin-1 as a therapeutic target for inflammatory bowel disease. [PDF]

Adv Pharmacol
Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the distal gastrointestinal tract, including Crohn's disease and ulcerative colitis. This chapter explores the potential of Dendritic cell-associated C-type lectin-1 (Dectin-1), a pattern recognition receptor, as a therapeutic target for IBD.
Li Y, Huang M, Cardinale S, Su Y, Peters DE, Slusher BS, Zhu X.   +6 more
europepmc   +3 more sources