Results 11 to 20 of about 18,918 (210)

Dependence on Dectin-1 Varies With Multiple Candida Species [PDF]

Frontiers in Microbiology, 2019
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs).
Aiysha Thompson, Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr   +10 more
doaj   +6 more sources

Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice [PDF]

mBio, 2013
We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a.
Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer   +4 more
doaj   +3 more sources

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. [PDF]

Sci Adv, 2023
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable expressivity are characteristic of IDAIL caused by CTLA-4 haploinsufficiency ...
Turnbull C, Bones J, Stanley M, Medhavy A, Wang H, Lorenzo AMD, Cappello J, Shanmuganandam S, Pandey A, Seneviratne S, Brown GJ, Meng X, Fulcher D, Burgio G, Man SM, de Lucas Collantes C, Gasior M, López Granados E, Martin P, Jiang SH, Cook MC, Ellyard JI, Athanasopoulos V, Corry B, Canete PF, Vinuesa CG.   +25 more
europepmc   +8 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Dectin-1/IL-15 Pathway Affords Protection against Extrapulmonary Aspergillus fumigatus Infection by Regulating Natural Killer Cell Survival

Journal of Innate Immunity, 2023
Aspergillus fumigatus is a ubiquitous, yet potentially pathogenic, mold. The immune system employs innate receptors, such as dectin-1, to recognize fungal pathogens, but the immunological networks that afford protection are poorly explored.
Fábio S.Y. Yoshikawa, Maki Wakatsuki, Kosuke Yoshida, Rikio Yabe, Shota Torigoe, Sho Yamasaki, Glen N. Barber, Shinobu Saijo   +7 more
doaj   +1 more source

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Cell Reports, 2015
Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer.
Lena Seifert, Michael Deutsch, Sara Alothman, Dalia Alqunaibit, Gregor Werba, Mridul Pansari, Matthew Pergamo, Atsuo Ochi, Alejandro Torres-Hernandez, Elliot Levie, Daniel Tippens, Stephanie H. Greco, Shaun Tiwari, Nancy Ngoc Giao Ly, Andrew Eisenthal, Eliza van Heerden, Antonina Avanzi, Rocky Barilla, Constantinos P. Zambirinis, Mauricio Rendon, Donnele Daley, H. Leon Pachter, Cristina Hajdu, George Miller   +23 more
doaj   +1 more source

Dectin-1-Independent Macrophage Phagocytosis of <i>Mycobacterium abscessus</i>. [PDF]

Int J Mol Sci, 2023
Mycobacterium abscessus, a species of nontuberculous mycobacteria (NTM), is an opportunistic pathogen that is readily cleared by healthy lungs but can cause pulmonary infections in people with chronic airway diseases. Although knowledge pertaining to molecular mechanisms of host defense against NTM is increasing, macrophage receptors that recognize M ...
Ochoa AE, Congel JH, Corley JM, Janssen WJ, Nick JA, Malcolm KC, Hisert KB.   +6 more
europepmc   +3 more sources

Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells [PDF]

, 2014
β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is ...
Adachi, Adams, Bert Devriendt, Berton, Bose, Brown, Brown, Brown, Bruno M. Goddeeris, Dawson, Dominguez, Donne, Du, Eric Cox, Estrada, Eva Sonck, Gantner, Huang, Janeway, Kasorn, Kawai, Kim Baert, Kingeter, Lehne, Li, Lowell, Mair, Marakalala, Means, Miyanishi, Mocsai, Olynych, Parsons, Piriou-Guzylack, Qi, Ramberg, Reid, Rice, Ross, Ross, Sonck, Sonck, Taylor, Taylor, Thornton, Underhill, van Bruggen, Vetvicka, Williams, Willment, Willment, Xia, Yakubenko, Yokota, Yuan, Zimmerman   +55 more
core   +2 more sources

Dectin-1 and its role in antifungal immunity [PDF]

Medical Mycology, 2008
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms.
Matti, Kimberg, Gordon D, Brown
openaire   +2 more sources

Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani [PDF]

, 2017
Purpose: Fusarium solani (F. solani) keratitis is a potentially sight-threatening fungal infection of the cornea. Antimicrobial peptides (AMPs), such as human β-defensins (hBDs) and cathelicidins, essential components of the immune system, likely have a ...
Baidouri, Hasna, Kolar, Satya Sree, McDermott, Alison   +2 more
core   +1 more source