Results 21 to 30 of about 21,245,874 (166)

Pattern recognition: recent insights from Dectin-1

Current Opinion in Immunology, 2009
The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase,
Reid, Delyth M, Gow, Neil AR, Brown, Gordon D   +2 more
openaire   +3 more sources

Role of <i>TLR2</i> rs5743708 and dectin-1 rs16910526 polymorphisms in susceptibility to fungal infections in COVID-19 patients. [PDF]

Cent Eur J Immunol
Introduction: The progression of fungal co-infection with COVID-19 depends on the patient's genetic innate immunity. Our goal is to understand the connection between the single nucleotide polymorphisms (SNPs) rs5743708 and rs16910526 in the toll-like ...
Mohammad KA, Ismael HM, Smail SW, Rasheed TK, Rahman MO, Albarzinji N, Salih RH, Taha KO, KHAleel KS, Amin K, Janson C.   +10 more
europepmc   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Dectin-1 and its role in antifungal immunity [PDF]

Medical Mycology, 2008
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms.
Matti, Kimberg, Gordon D, Brown
openaire   +2 more sources

Dectin-1 staining of WT hyphae, WT yeast and eng1 ywp1 yeast using laminarin and secondary antibody only as staining controls.

, 2022
Hyphae was induced in YPD for 1 h at 37°C. WT and eng1 ywp1 yeast were cultured in YPD for 6h at 30°C. Dectin-1-Fc was pre-incubated with 1mg/mL of laminarin for 20 minutes before added to fixed cells and incubated for 1 hour.
Daidong Wang (11919948), Michaela Marshall (6912062), Mengli Yang (4818078), Scott G. Filler (202661), Marc Swidergall (185453), Haoping Liu (170993), Eric Pearlman (246406), Rachel Garleb (11919945), Tingting Zhou (163678), Norma V. Solis (8339217)   +9 more
core   +1 more source

Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice [PDF]

mBio, 2013
ABSTRACTWe assessed the role of Dectin-1 in the immune response to the pathogenic fungusCoccidioides, bothin vitroandin vivo, using mice with a targeted mutation inClec7a. Elicited peritoneal macrophages responded to formalin-killed spherules (FKS) and alkali-treated FKS by secreting proinflammatory cytokines in a Dectin-1- and β-glucan-dependent ...
Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer   +4 more
openaire   +3 more sources

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Lech, Maciej, Günthner, Roman, Regina Gröbmayr, Römmele, Christoph, Heni Eka Susanti, Susanti, Heni Eka, Heni Susanti, Maciej Lech, Roman Günthner, Hans-Joachim Anders, Christoph Römmele, Gröbmayr, Regina, Anders, Hans-Joachim   +12 more
core   +1 more source

Dectin-1 Is A Major β-Glucan Receptor On Macrophages [PDF]

The Journal of Experimental Medicine, 2002
Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and complement receptor 3 (CR3) have historically been considered the major macrophage lectins involved in the nonopsonic recognition of these yeast-derived ...
Brown, Gordon D., Taylor, Philip R., Reid, Delyth M., Willment, Janet A., Williams, David L., Martinez-Pomares, Luisa, Wong, Simon Y.C., Gordon, Siamon   +7 more
openaire   +5 more sources

Dectin-1 alone does not recognize cryptococcal spores.

, 2017
(A) Reporter cells expressing mouse FcRγ chain only (FcR), Mincle and FcRγ chain together (Mincle+FcR), MCL and FcRγ chain together (MCL+FcR), Dectin-2 and FcRγ chain together (Dec-2+FcR), and Dectin-1-CD3ζ (Dec-1) were left unstimulated (black bars ...
Naomi M. Walsh (3830494), Marcel Wuthrich (3830491), Christina M. Hull (366731), Huafeng Wang (2304877), Bruce Klein (432955)   +4 more
core   +1 more source

Dectin-1, MR and Dectin-2 mainly bind to the surface of F. pedrosoi-hyphae, but not the transformed sclerotic cells.

, 2018
(A-C) The binding of murine-derived Dectin-1, Mannose Receptor (MR), and Dectin-2 to F. pedrosoi cultured in ATCC 830 medium with 10−6 M PAF at 35°C for 30 days was detected respectively by PE-conjugated anti-murine Dectin-1 mAb (A), FITC-conjugated anti-
Yiqun Duan (295026), Sharon C.-A. Chen (342075), Dongsheng Li (222712), Bilin Dong (295021), Weihuang Liu (172053), Liuqing Chen (295025), Yao Chen (149006), Xu Zhang (49484), Zhongsheng Tong (295022), Ruoyu Li (74020), Wei Liu (20030)   +10 more
core   +1 more source