Results 21 to 30 of about 18,918 (210)

Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

Frontiers in Microbiology, 2021
More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C.
Aiysha Thompson, Aiysha Thompson, Diogo M. da Fonseca, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, James S. Griffiths, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr, Selinda J. Orr   +12 more
doaj   +1 more source

Expression of dectin-1 during fungus infection in human corneal epithelial cells

International Journal of Ophthalmology, 2014
AIM:To evaluate the expression of dendritic cell-associated C-type lectin-1 (dectin-1) in human corneal epithelial (HCE) cells infected by fungus.METHODS:A total of 20 cases of healthy donor corneas were group A, and 20 patients (20 eyes) suffered from ...
Cui Li, Gui-Qiu Zhao, Cheng-Ye Che, Na Li, Jing Lin, Qiang Xu, Qian Wang, Ying Liu, Sheng Qiu   +8 more
doaj   +1 more source

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira, Anders, Bjorge, Camby, Caminschi, Christoph Römmele, Elola, Ferwerda, Geijtenbeek, Gingras, Gringhuis, Gross, Hans-Joachim Anders, Heil, Heni Eka Susanti, Hornung, Kimbrell, Kock, Kono, Kronin, Kulkarni, Lassen, Lech, Lech, Lech, Lopez-Guisa, Maciej Lech, Medzhitov, Mocsai, Osorio, Patole, Rakoff-Nahoum, Regina Gröbmayr, Roman Günthner, Schreibelt, Skuginna, Van Vliet, Wagner, Zarember, Zhang   +39 more
core   +5 more sources

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]

, 2013
Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V., Bratton, Donna L., Brown, Gordon D., Gow, Neil A. R., Leslie, Christina C., Mahaffey, Spencer, Murphy, Robert C., Silveira, Lori J., Suram, Saritha, Williams, David L.   +9 more
core   +16 more sources

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

PLoS Pathogens, 2011
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses.
Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek   +7 more
doaj   +1 more source

Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells

Frontiers in Immunology, 2021
The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L and CCL17 expression by myeloid dendritic cells (mDCs), which contributes to aberrant Th2-type immune responses.
Chao Gu, Katherine Upchurch, Joshua Horton, Mathew Wiest, Mathew Wiest, Sandra Zurawski, Mark Millard, Robert R. Kane, Robert R. Kane, HyeMee Joo, HyeMee Joo, Lisa A. Miller, SangKon Oh, SangKon Oh   +13 more
doaj   +1 more source

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells [PDF]

, 2012
Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells.
Akira, Anderson, Anna Karolina Palucka, Anne O’Garra, Anne-Laure Flamar, Awasthi, Bacchetta, Banchereau, Banchereau, Barrat, Baumgart, Bergman, Brown, Caparrós, Caux, Dapeng Li, Delneste, Dillon, Dorothée Duluc, Dudziak, Feng, Figdor, Gabrielle Romain, Gabrysová, Geijtenbeek, Geijtenbeek, Gerard Zurawski, Geurtsen, Gringhuis, Gringhuis, Groux, Häringer, Ito, Jacques Banchereau, Jankovic, Kaiser, Kappos, Klechevsky, LeibundGut-Landmann, Levings, Macián, Maldonado-López, Melissa Dullaers, Moore, Nathalie Bosquet, Ni, O’Garra, Pulendran, Reddy, Rissoan, Roger Le Grand, Rogers, Roncarolo, Sagoo, Saijo, Sandra Zurawski, SangKon Oh, Saraiva, Saraiva, Schreiber, Shortman, Smits, Soares, Steinman, Trinchieri, Valladeau, Xiao-Hua Li   +66 more
core   +2 more sources

Dectin-1-Mediated DC-SIGN Recruitment to Candida albicans Contact Sites

Life, 2021
At host–pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C.
Rohan P. Choraghe, Aaron K. Neumann
doaj   +1 more source

Dectin-1

, 2004
In host defence, pattern recognition plays an essential role by enabling the immune system to discriminate self from pathogenic non-self. Pattern recognition is mediated by leukocyte expressed pattern recognition molecules (PRMs), which recognise pathogen associated molecular patterns (PAMPs) on pathogens.
Herre, Jürgen., Herre, Jürgen
openaire   +2 more sources

Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.

PLoS Pathogens, 2017
Inflammasome is an intracellular protein complex that serves as cytosolic pattern recognition receptor (PRR) to engage with pathogens and to process cytokines of the interleukin-1 (IL-1) family into bioactive molecules.
Tzu-Hsuan Chang, Juin-Hua Huang, Hsiu-Chao Lin, Wen-Yu Chen, Yu-Hsiang Lee, Li-Chung Hsu, Mihai G Netea, Jenny P-Y Ting, Betty A Wu-Hsieh   +8 more
doaj   +1 more source