旋毛虫排泄分泌抗原53-ku重组蛋白上调M2型肺泡巨噬细胞减轻脓毒症小鼠急性肺损伤
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨重组旋毛虫排泄分泌抗原53-ku蛋白（rTsP53）对小鼠急性肺损伤的保护作用及其机制。【方法】采 用尾静脉脂多糖注射（LPS，10 mg/kg）建立BALB/c小鼠急性肺损伤模型。在肺损伤后2 h尾静脉注射rTsP53（50 μg/只）治 疗。统计各组小鼠72 h累计死亡率，HE染色法观察各组小鼠肺脏病理损伤情况，测量肺脏湿/干质量比（W/D），ELISA法检 测各组小鼠肺泡灌洗液 IL-6 和 IL-4 浓度，RT-PCR 法检测各组小鼠肺泡灌洗巨噬细胞 TNF-α、iNOS、IL-
关开泮 +3 more
doaj
Progress in the role of exosomes in sepsis⁃induced cardiomyopathy [PDF]
"Sepsis is a life⁃ threatening organ dysfunction triggered by a dysregulated host response to infection. Sepsis⁃ induced cardiomyopathy（SICM）is an acute cardiac condition caused by sepsis，characterized by high incidence and extremely high mortality ...
ZHENG Ye*，LI Shaoling，HAN Fei
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急性白血病患者血清SDF-1、GM-CSF、α-HBDH的表达水平及临床意义
Zhongguo shiyan zhenduanxue, 2018 基质细胞衍生因子-1（SDF-1）可通过细胞因子的网络系统影响机体造血、免疫、血管发育等多种生理病理过程,可与CXCR4相互作用,从而对急性白血病具有促进作用[1];粒细胞-巨噬细胞集落刺激因子（GM-CSF）在早期造血阶段具有一定的光谱效应,在放化疗所致造血功能障碍恢复中具有积极作用[2]。此外,急性白血病不仅外周血以及骨髓表现异常,其酶学表达同样存在异常 ...
杨娜 +5 more
doaj
Mechanism of astragaloside Ⅳ remodeling tumor immunosuppressive microenvironment [PDF]
Tumor immunosuppressive microenvironment (TIME) plays a crucial role in tumor growth and immune escape. A number of studies have found that Astragaloside Ⅳ (AS-Ⅳ) effectively reshaped TIME by reducing the expression of programmed cell death ligand 1 (PD ...
FU Nan*, ZHANG Siyue, WANG Jinhua
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Pathological Characteristics and Classification of Unstable Coronary Atherosclerotic Plaques [PDF]
Important forensic diagnostic indicators of sudden death in coronary atherosclerotic heart disease, such as acute or chronic myocardial ischemic changes, sometimes make it difficult to locate the ischemic site due to the short death process, the lack of ...
Yun-hong XING, Yang LI, Wen-zheng WANG, Liang-liang WANG, Le-le SUN, Qiu-xiang DU, Jie CAO, Guang-long HE, Jun-hong SUN
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, 2019 肝脏作为体内代谢外源因素暴露最重要的器官之一,具有独特的血窦结构和丰富的免疫细胞亚群,构成了肝脏局部免疫微环境。其中,肝脏的先天免疫细胞既可通过清除病原体、抗原提呈作用参与宿主防御,还通过与肝实质细胞的相互作用参与外源因素介导的急性免疫反应、肝细胞毒性转归、慢性肝损伤以及肝致癌作用。线粒体作为细胞应激的关键靶细胞器,是整合肝脏局部免疫信号的分子互作平台,既通过线粒体质量控制精细调控细胞内的分子事件,也通过线粒体损伤相关分子模式介导不同细胞间通讯和交互作用调控免疫微环境的稳态 ...
张力引, 林忠宁, 林育纯
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Research Progress on the Pathogenesis of Sarcopenia and the Mechanism of Action and Application of Natural Active Components in Alleviating and Preventing This Disease [PDF]
Sarcopenia is a progressive, systemic skeletal muscle disorder associated with aging. With the increase in the global aging population, sarcopenia has become a significant health issue for the elderly. Studies have shown that natural bioactive compounds,
DING Xiaoyu, JIA Lei, LIU Huimin, LIU Jingsheng
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Mechanism of Nrf2 in the treatment of ulcerative colitis via regulating macrophage polarization. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Zhang Y, Liu Y, Yang S, Yan S.
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CX3CR1 regulates the development of renal interstitial fibrosis through macrophage polarization. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Xu L +5 more
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Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection [PDF]
Heart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection.
LIU Dezhao, ZENG Zhiyu
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