Results 41 to 50 of about 1,791 (123)
大黄素对糖尿病肾病小鼠AMPKα1/TLR4/p65信号通路的影响 [PDF]
, 2019 目的观察大黄素(Emodin)对糖尿病肾病(DN)模型小鼠AMPKα1/TLR4/p65信号通路的影响。方法采用SPF级雄性KK-Ay小鼠,经高脂饲料诱导3周建立DN模型,将30只模型成功KK-Ay小鼠随机分为模型组,阳性药组,大黄素高、中、低剂量组,每组6只,另将6只雄性C57BL/6J小鼠设为正常组,分组后大黄素低剂量组由于操作失误导致1只小鼠死亡。正常组及模型组予去离子水10 ml/(kg·d),阳性药组予缬沙坦13. 33 mg/(kg·d),大黄素各组分别予大黄素13. 33 mg/(kg·d)
卜祥伟 +9 more
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浙江大学学报. 医学版铁死亡是一种依赖铁代谢失衡并以脂质过氧化为特征的调控性细胞死亡形式，在多种病理过程中发挥关键作用。研究表明，铁死亡的发生与肝细胞癌（HCC）的进展密切相关。铁死亡参与调控HCC的脂质代谢、铁离子稳态、线粒体代谢和氧化还原过程，在HCC肿瘤免疫中发挥着关键作用。铁死亡通过调节免疫微环境中不同细胞的表型和功能影响肿瘤的免疫逃逸和进展；铁死亡诱导的脂质过氧化物和氧化应激能促进M1型巨噬细胞的极化，增强肿瘤的促炎反应，同时抑制髓源性抑制细胞和调节性T细胞等免疫抑制细胞的功能，从而破坏免疫抑制 ...
莫 宇倩, 邹 志霖, 陈 二宝
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Recent Progress in Understanding the Mechanism of Action of Lactic Acid Bacteria in Promoting Calcium Absorption in the Human Body [PDF]
More and more evidence shows that lactic acid bacteria play an important role in improving calcium absorption and promoting bone health. However, there is a lack of systematic research on the mechanism by which lactic acid bacteria promote calcium ...
MA Zhihe, WANG Ruixue, WANG Junguo
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Zhongguo shiyan zhenduanxue目的 探讨烟曲霉孢子诱导M1型巨噬细胞极化的分子机制。方法 分离外周血单核细胞，体外经PMA刺激后诱导成M0巨噬细胞，经烟曲霉活化孢子刺激培养2 d后检测巨噬细胞表型和特征基因表达，确定其极化类型。流式细胞术(Flow Cytometry, FCM)、实时定量反转录聚合酶链式反应(Real-Time Quantitative Reverse Transcription, qRT-PCR)确定巨噬细胞极化状态，免疫共沉淀(Western-Blotting)法检测Dectin-1 ...
张晓威 +3 more
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, 2019 【目的】探讨伊马替尼（Ima）在体外对脂多糖（LPS）诱导的RAW264.7巨噬细胞炎症表型的影响。【方法】RAW264.7细胞在LPS（0.1μg/mL）或/和Ima（1μmol/L，5μmol/L）处理后，通过Q-PCR方法检测细胞因子IL-1β、IL-10、CCL2、iNOS、TNF-α和Arg1的mRNA表达变化；采用Western Blot检测iNOS蛋白表达变化以及NF-κB和MAPK信号通路活化情况；利用ELISA法检测细胞上清IL-1β、CCL2、IL-10和TNFα的蛋白表达情况 ...
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine [PDF]
Sepsis is a systemic inflammatory response syndrome caused by infection，with resulting organ dysfunction being the key factor in mortality. The lung is one of the organs most frequently affected by sepsis. Recent studies have shown that active components
RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin
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Significant fundamental translational research on breast cancer in China: progress and prospects [PDF]
Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through
LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin
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nIL-33介导的巨噬细胞极化在口腔鳞状细胞癌中的作用及机制研究进展
Zhongguo shiyan zhenduanxue口腔鳞状细胞癌（OSCC）是世界范围内最常见的头颈部恶性肿瘤，OSCC的发生与口腔黏膜的癌前病变密切相关。巨噬细胞是黏膜免疫的重要参与者，通过调控不同表型的极化状态促进OSCC进展。核白细胞介素-33（nIL-33）通过调控细胞线粒体代谢重塑巨噬细胞极化。本文系统综述巨噬细胞与口腔鳞癌进展的关系，从细胞核-线粒体调控极化表型角度阐明巨噬细胞极化自我调控机制，以期为靶向巨噬细胞抗OSCC治疗提供思路和参考。
王娜 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban口腔白斑病是一种发病率高的潜在恶性黏膜疾患，巨噬细胞在口腔白斑病恶性转化中发挥重要调控作用，但该过程的分子机制研究存在不足。近年研究发现巨噬细胞M2极化对口腔白斑恶性转化具有显著影响，且该过程受到免疫细胞、微生物、细胞因子、细胞外基质等一系列复杂的网络调控。因此本文就巨噬细胞在口腔白斑中的生物学功能、亚型以及其极化的调控因素进行综述，并结合课题组在口腔胞内定植菌与黏膜恶性肿瘤关系的前期研究基础，提出口腔胞内定植菌如牙龈卟啉单胞菌等可能通过促进巨噬细胞M2极化诱导免疫抑制微环境并最终促进白斑恶性转化的机制，
贾益群, 郑雨燕
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Experimental study of artesunate ameliorating head-and-neck radiation-induced skin fibrosis in rats through inhibiting Stat3/TGF-β1 signaling pathway [PDF]
Objective To study the effect and mechanism of artesunate (ART) in improving radiation-induced skin fibrosis (RISF) induced by head-and-neck radiotherapy in rats. Methods Thirty Sprague-Dawley rats were randomly divided into three groups: a control group,
NONG Xiaolin, OU Jianbo, TANG Chan
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