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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Involvement of let-7c in alveolar macrophage M2 polarization in coal mine dust-induced epithelial-mesenchymal transition in rat lung tissue [PDF]
BackgroundCoal workers' pneumoconiosis (CWP) is a serious occupational lung disease and one of the prescript occupational diseases in China. Epithelial-mesenchymal transition (EMT) is involved in the diffuse fibrosis of lung tissue of pneumoconiosis ...
Huifang ZHANG +5 more
core +1 more source
The role of wound macrophage anti-inflammatory polarization and MANF production in the treatment of diabetic foot with tibial cortex transverse transport [PDF]
Objective To investigate the correlation between midbrain astrocyte-derived neurotrophic factor (MANF) levels in peripheral blood and local wound of diabetic foot patients and the anti-inflammatory polarization of macrophages induced by tibial cortex ...
HUA Qikai +3 more
core +1 more source
New insights in small airway dysfunction of childhood asthma [PDF]
, 2023 Small airway dysfunction (SAD) widely exists in different stages of childhood asthma, which is based on airway inflammation, airway remodeling and airway hyperresponsiveness. Among them, airway inflammation is the main pathological feature of SAD. It has
DONG Xiaoyan, ZHU Siyu
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Research progress on lactylation in atherosclerosis [PDF]
Atherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular ...
LAN Yining, MO Qin, QIN Chao
core +1 more source
TFF2 Regulates LPS-induced Macrophages Polarization and Inhibits Inflammation [PDF]
, 2017 病原感染修复过程中，不同极化分型的巨噬细胞与微环境相互作用，启动促炎或抗炎机制：一方面，巨噬细胞M1型活化，释放炎症介质，导致炎症发生，进而损伤；另一方面，巨噬细胞M2型活化启参与炎症控制和寄生虫感染抵抗，并在组织修复与重建、脂类代谢、过敏反应和肿瘤形成中发挥作用。两种机制相互拮抗共同决定着炎症的发生发展及转归。因此，巨噬细胞不仅是重要的疾病治疗靶点，其极化调控也成为研究热点之一。最新研究进展提示脂多糖（LPS）是炎症和巨噬细胞M1型极化的强大诱导剂。LPS主要通过TLRs受体激活NF- ...
吴晓玲
core
Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization [PDF]
Objective: To explore the molecular mechanism by which ginseng-derived nanoparticles (GDNPs) inhibit the growth of human non-small cell lung cancer cells (A549) by altering the polarization state of macrophages.
Daqing ZHAO +7 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2018 目的检测姜黄素对LPS诱导小鼠巨噬细胞极化的影响,并检测不同极化状态下细胞培养上清对小鼠胰岛β细胞的损伤作用;研究姜黄素通过拮抗LPS诱导巨噬细胞M1极化保护胰岛β细胞的效应与机制。方法体外培养小鼠小鼠巨噬细胞RAW264.7细胞,通过LPS（2μg/ml）诱导建立M1极化模型,采用姜黄素（7.5 1μmol/l）单独或与LPS共同处理细胞。通过流式细胞术检测巨噬细胞CD40、CD86和CD206表达,并通过ELISA技术检测细胞培养上清液中TNF-α含量 ...
史立言 +4 more
doaj
Traditional Chinese Medicine Regulates Tumor-associated Macrophages in Colorectal Cancer：A Review [PDF]
Colorectal cancer（CRC），a most common malignant tumor of the digestive tract，is often manifested by abdominal pain，changes in stool quality，blood in the stool，and weight loss，with rising morbidity and mortality year by year.
Cai, Mengyuan +5 more
core +2 more sources
变应性鼻炎患者血浆细胞外囊泡对树突状细胞和巨噬细胞的调控作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的树突状细胞（DCs）和巨噬细胞（Mφ）在变应性鼻炎（allergic rhinitis， AR）的发病过程中起重要调控作用。本研究主要探讨AR血浆细胞外囊泡（EVs）对DCs和Mφ分化的调控作用。方法招募健康志愿者（HC）和AR患者各6人，应用超速离心法制备HC-EVs和AR-EVs；将磁珠分选所得人CD14+单核细胞在体外分别诱导分化成DCs和Mφ，并用5×108/mL HC-EVs和AR-EVs分别对单核细胞、DCs和Mφ进行刺激，通过ELISA、聚合酶链反应（PCR）或流式分析的方法进行分析 ...
方淑斌, 付清玲
doaj