Results 11 to 20 of about 1,791 (123)
Zhongguo shiyan zhenduanxue, 2021 目的研究D-缬氨酸对巨噬细胞M1极化的影响。方法在不同浓度的D-缬氨酸情况下,通过CCK-8方法测定分析细胞毒性,利用实时PCR分析多个基因的mRNA表达。然后通过Elisa方法检测IL-6,IL-1β,TNF-α的蛋白表达,使用荧光显微镜分析iNOS表达。结果 50mM D-缬氨酸对巨噬细胞没有细胞毒性,D-缬氨酸在mRNA和蛋白质水平下调IL-6,IL-1β和TNF-α的表达,细胞中iNOS也下调明显。结论 D-缬氨酸抑制RAW264.7巨噬细胞中LPS/IFN-γ诱导的M1巨噬细胞极化。
倪宇昕, 王勇, 邓艳芳
doaj
Latest Research Development in Histone Acetylation in the Pathogenesis of Asthma [PDF]
, 2022 Asthma is primarily marked by airway hyperresponsiveness, inflammation, and remodeling. Histone acetylation is one of the most common epigenetic modifications that regulates histone acetyltransferase and histone deacetylase, and imbalanced regulation may
CHEN Shaopeng, ZENG Minjuan, LAI Tianwen
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Research Progress on the Influence of Intermittent Fasting on Cardiovascular Disease Risk Factors [PDF]
, 2022 In recent years, the prevalence and mortality of cardiovascular diseases in China have shown a significant upward trend, cardiovascular disease has become a major disease endangering the health of Chinese residents.
CUI Yanru, CEN Qiuyu, WEI Juanfang, WANG Wenchun, ZHANG Anren
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Fructose regulates M1 macrophage polarisation by promoting glycolysis [PDF]
Objective To investigate the regulatory effect of fructose (Fru) on the polarization of M1 macrophages induced by lipopolysaccharide (LPS) and interferon gamma (IFN-γ) and its possible mechanism.
CHEN Sihong +9 more
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Research progress on roles of ultraviolet irradiation in diseases [PDF]
, 2023 The electromagnetic spectrum emitted by the sun includes visible light, infrared, and ultraviolet (UV). Among them, UV is one of the hotspots of research.
Qianqian ZHU +3 more
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Experimental study on the effect of lncRNA-Scarna10 on resveratrol-induced M2 polarization of macrophages [PDF]
Objective To investigate the effect of lncRNA-Scarna10 (Scarna10) on resveratrol (RSV)-induced polarization of macrophages. Methods M1 polarization model of RAW264.7 macrophages was established by LPS and treated with RSV for 24 hours.
CHENG Dongyu +6 more
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Research progress in the role of M1/M2 polarization of macrophages in different liver diseases [PDF]
Macrophages have strong plasticity and heterogeneity, and can undergo functional transformation in response to different signal stimuli, such as classical activation of M1 type (M1 type polarization) and selective activation of M2 type (M2 type ...
LI Zhengju +5 more
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Effects of Treponema pallidum on THP-1 derived macrophage polarization [PDF]
, 2015 梅毒螺旋体（Treponemapallidum）是性传播疾病梅毒的致病菌，尽管有关T.pallidum的研究已经开展近一个多世纪，对其生物学及病原学特性有了一定的了解，然而对于T.pallidum致病机制的认识还处于起步阶段。巨噬细胞作为机体防御外来病原体的第一道防线，在对T.pallidum的识别、吞噬、抗原提呈、杀伤等方面均发挥着重要作用。随着对巨噬细胞研究不断深入，有学者将巨噬细胞分为两种不同的极化类型，即促进炎症发展的M1型巨噬细胞和在抑制炎症反应及组织修复等方面发挥作用的M2型巨噬细胞 ...
席亚
core
Physiological function of nerve injury-induced protein 1 and its role in relevant diseases [PDF]
, 2023 Nerve injury-induced protein 1 (NINJ1) is a cell-surface adhesion molecule containing an extracellular adhesion domain and two transmembrane domains. NINJ1 is named for its original discovery in damaged nerve endings.
LU Xinwu +4 more
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