Preparation and Characterization of Liposomes Encapsulating Cyclina sinensis Immunoreactive Peptides(包埋青蛤免疫活性肽脂质体的制备及性质表征) [PDF]
Shipin kexue jishu xuebaoTo further exploit the immunomodulatory effects of Cyclina sinensis immunoreactive peptides (SCSP) and to seek a better method of peptide delivery, liposome technology was employed to encapsulate SCSP.
WANG Zhen(王震) +4 more
doaj +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】研究间充质干细胞（MSC）是否可以通过诱导肺泡巨噬细胞向M2型极化来改善急性肺损伤。【方法】①贴壁法提取脐带MSC，用流式细胞仪分析细胞表型，细胞化学染色法观察细胞体外成骨和成脂肪能力。②小鼠肺泡巨噬细胞系（MH-S细胞）加入脂多糖（LPS）刺激，和MSC隔离共培养，并加入MSC可溶性因子抑制剂，设置LPS组、LPS+MSC组和MSC抑制剂组，共培养48h后用流式和qPCR技术分析巨噬细胞极化状态。③30只balb/c雄性小鼠随机均分成control组、ALI组、ALI+MSC组（均n=10 ...
孙瑶 +4 more
doaj
Research progress on graphene and its derivatives modulating the bone regeneration microenvironment [PDF]
Graphene family nanomaterials (GFNs) are highly popular in the field of bone tissue engineering because of their excellent mechanical properties, biocompatibility, and ability to promote the osteogenic differentiation of stem cells.
LAN Yuanchen, LIN Hengyi, JIANG Yukun, HU Zhiai, ZOU Shujuan
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Engineering of mesenchymal stem cell-derived exosomes and their application progress in the field of oral medicine [PDF]
In recent years, mesenchymal stem cell-derived exosomes (MSC-EXO) have garnered increasing attention in the field of stomatology and have become an established research area in biomedical research. This article reviews the engineering of exosomes derived
ZHAO Yunfeng, LIU Qian, LI Meng, LI Luying, ZHANG Wei, HU Xiantong, MA Chufan
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Toxic effects of indium tin oxide nanoparticles on macrophages [PDF]
Objective The toxic effects of indium tin oxide nanoparticles (ITO NPs) on RAW264.7 macrophages, including cell viability, oxidative stress, and inflammatory cytokine release, were studied in order to elucidate the underlying mechanisms of ITO NPs ...
ZHANG Yu
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Novel Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia [PDF]
, 2016 缺血乏氧是肿瘤微环境的重要特征之一，肿瘤的缺血乏氧不仅促进了肿瘤细胞的侵袭转移，同时还增强肿瘤对化疗药物的耐药性。肿瘤相关巨噬细胞（Tumor-associatedmacrophages，TAMs）浸润在肿瘤微环境之中，通常在肿瘤缺血乏氧区域富集。肿瘤相关巨噬细胞作为肿瘤微环境的重要功能细胞，其在肿瘤细胞的增殖、侵袭、转移、化疗耐药等肿瘤进展的各个阶段均发挥着重要作用。鉴于此，我们提出一种新型的肿瘤治疗策略，以期改变肿瘤微环境的同时，增强实体瘤对化学治疗的疗效 ...
宋曼莉
core
The role of macrophage metabolic reprogramming in myocardial infarction [PDF]
Myocardial infarction (MI) is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis.
CHENG Xiang, GU Muyang, ZOU Zicong
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Zhongguo shiyan zhenduanxue动脉粥样硬化是一种主要累及大中型动脉的慢性炎症性疾病,是心血管疾病如冠心病的主要病理学基础。巨噬细胞是先天性免疫细胞,其作为抵御入侵人体病原体的第一道防线在免疫应答中起着重要的作用。巨噬细胞是心脏中含量最多的免疫细胞,同时也是动脉粥样硬化中病变最丰富的免疫细胞类型,几乎贯穿整个病理过程。巨噬细胞谱系的多样化和高度可塑性是其发挥功能的关键,在不同的微环境刺激下可以分化为促炎或抗炎表型并且发挥相应的功能。再者巨噬细胞代谢,如糖酵解、三羧酸循环、脂质和氨基酸代谢的改变也会影响巨噬细胞的表型和功能 ...
杨楠 +4 more
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Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy [PDF]
Objective·To investigate the effects of trimethylamine oxide (TMAO) on cardiac function in mice with hypertrophic cardiomyopathy (HCM) and its potential molecular mechanism.Methods·Mice with myosin heavy chain 6 (Myh6) c.1211G>A (p.R404Q+/-) point ...
CHEN Hanzhang +8 more
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Research progress of plant exosome-like nanoparticles on characteristics, components and functions [PDF]
Exosome-like nanoparticles （ELNs） are nano-sized extracellular vesicles enclosed by lipid bilayer membrane and secreted by cells; And carrying a variety of cargo, including lipids, proteins, miRNAs and secondary metabolites.
CHEN Chunping +4 more
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