Results 61 to 70 of about 1,791 (123)
单羧酸转运蛋白4调控口腔鳞状细胞癌肿瘤相关巨噬细胞极化的机制研究
Zhongguo shiyan zhenduanxue目的探讨靶向抑制单羧酸转运蛋白4（MCT4）对肿瘤相关巨噬细胞（TAMs）极化的影响及机制。方法采用佛波醇-12-十四酸酯-13-乙酸酯（PMA）诱导人单核细胞白血病细胞（THP-1）为巨噬细胞后，以MCT4特异性抑制剂VB124或二甲基亚砜（DMSO）预处理，再与人口腔鳞状细胞癌（OSCC）细胞株CAL27进行Transwell共培养诱导TAMs。蛋白免疫印迹（Western blot）法检测巨噬细胞和TAMs中MCT4的蛋白表达;流式细胞术、免疫荧光染色以及Western ...
刘璐 +4 more
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Linchuang shenzangbing zazhi, 2014 目的 肾间质呈肉芽肿样改变是少见的病理表现,既往报道的病因多为结节病、药物、感染、结核导致的肾间质肉芽肿样改变。本研究拟了解肾间质呈肉芽肿样改变的病因、临床特点及预后。方法 回顾性分析四川省人民医院肾内科2006年7月至2013年6月共2 330例肾活检患者资料,其中肾活检组织肾小球数目大于10个的患者纳入分析。免疫组织化学染色方法标记CD3 T淋巴细胞、CD20B淋巴细胞、CD68单核巨噬细胞在肾间质的表达。结果 表现为肉芽肿样间质肾炎的8例患者占肾活检的0.34%(8/2 330),其中男女各半 ...
王蔚
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[Research progress on the effect of iron oxide nanoparticles in macrophage polarization]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023 Zhang H +5 more
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[Influencing Factors and Significance of Tumor-associated Macrophage Polarization in Tumor Microenvironment]. [PDF]
Zhongguo Fei Ai Za Zhi, 2023 Ge W, Wu W.
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Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization. [PDF]
J Zhejiang Univ Sci B, 2023 You C +5 more
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Advances in the interaction between intestinal macrophages and the gut microbiota in intestinal diseases [PDF]
The human body harbors a vast array of microorganisms on its surface, with the intestine serving as the primary habitat. The gut microbiota comprises thousands of species of bacteria, viruses, fungi, and protozoa, forming a vast and dynamic microbial ...
CHEN Xiuqi +3 more
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Intratumoral Microbiota Promotes Tumor Progression by Modulating Tumor Metabolism [PDF]
A wealth of prior studies has confirmed that intratumoral microbiota can survive within tumor tissue, thereby promoting or inhibiting tumor growth. With the development of high-throughput sequencing and metabolomics, increasing attention has been paid to
Liyuan FANG +4 more
core +1 more source
微小RNA146b通过靶向调节干扰素调节因子5控制M1型巨噬细胞极化
Zhongguo shiyan zhenduanxue, 2017 目的为了证实miR-146b在小鼠M1/M2型巨噬细胞分化平衡中的作用和机制,我们通过分离小鼠骨髓来源巨噬细胞,在LPS和IFN-γ联合刺激下促进M1型细胞分化;并结合李斯特菌感染和内毒性休克,共同证实miR-146b对M1型巨噬细胞分化的作用。方法分离野生型（WT）和IL-10-/-小鼠骨髓细胞,采用GM-CSF诱导成为巨噬细胞。并在IL-10-/-M1型巨噬细胞中转染miR-146bmimic;评价miR-146b对M1型巨噬细胞分化的影响,以及致炎因子TNF-γ、IL-6和IL-12等表达 ...
胡晶晶, 李开学, 刘若丹, 熊鹰
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Zhongguo shiyan zhenduanxue目的 探究Dectin-1通过巨噬细胞极化影响STEMI的机制研究。方法 将45只SPF级SD大鼠随机分为假手术组(n=15)、模型组(n=15)、si-Dectin-1组(n=15),模型组与si-Dectin-1组分别通过尾静脉注射NC-质粒和si-Dectin质粒，2周后建立ST段抬高型心肌梗死(ST-Segment Elevation Myocardial Infarction, STEMI)模型，2周后分离心脏组织，qPCR检测心脏组织Dectin-1表达水平，TTC染色检测心肌坏死面积 ...
孙倩, 苏艳, 张雅兰, 李晓林
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[Research progress on the regulation of macrophage polarization by mechanical stimulation in wound healing]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2022 Xu C, Yu D, Zhu H.
europepmc +1 more source