Results 11 to 20 of about 23,950 (124)
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang +14 more
wiley +1 more source
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Weaving knowledges to support wildlife health surveillance in Kenya's pastoral rangelands
Abstract In wildlife–livestock–human interfaces, pathogens capable of spreading between wild and domestic animals and humans have important implications for conservation outcomes, economics, and public health. Robust wildlife health surveillance can help address these risks.
Brock Bersaglio +4 more
wiley +1 more source
ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
高同型半胱氨酸血症与非胰岛素依赖性糖尿病心、脑血管并发症关系 附视频
目的 探讨血清总同型半胱氨酸(tHcy)水平与非胰岛素依赖性糖尿病(2型DM)心脑血管并发症的关系。方法以高压液相色谱(HPLC)荧光检测法测定了30例正常人和78例2型DM患者(其中32例无并发症,46例伴有心、脑血管并发症)的血清tHcy水平。结果对照组血清tHey水平为10.8213.68μmol/L,2型DM无并发症患者tHey水平为17.32±5.63μmol/L, 2型DM伴有心脑血管并发症患者tHey水平为 27.43±8.86μmol/L,统计学结果表明对照组、2型 ...
王天成 +1 more
doaj
目的 探讨胰腺外感染(Extrapancreatic infection,EPI)对急性胰腺炎(Acute pancreatitis,AP)并发症和预后的影响。方法 回顾性分析2018年4月至2019年10月南通大学附属海安医院收治的182例AP患者的临床资料,统计EPI发生情况,对比有无并发EPI患者在胰腺坏死、持续性器官功能衰竭、死亡方面的差异,分析导致患者死亡的相关因素。结果本组57例(31.3%)AP患者并发EPI,其中45例(24.7%)AP患者并发1种EPI、10例(5.5%)并发2种EPI、
黄海龙, 周蓉, 王娟, 吴应冬
doaj

