Results 11 to 20 of about 3,303 (156)
环状RNA circ_0120051通过miR-144-3p/IDH2轴抑制心肌成纤维细胞的纤维化表型研究 [PDF]
目的研究环形 RNA circ_0120051对心肌成纤维细胞的纤维化表型的调控作用和机制。方法通过实时萤光定量PCR（RT-qPCR）检测健康器官捐献者（n=24）与心力衰竭（HF）病人（n=21）心肌标本中 circ_0120051及其宿主基因溶质载体家族8成员A1（SLC8A1）的表达水平。核糖核酸外切酶（RNase R）消化实验鉴定circ_0120051的RNA稳定性。RT-qPCR检测circ_0120051在人心肌细胞AC16中的核质分布情况。利用腺病毒在C57BL/6乳小鼠心肌成纤维细胞（
伍华燕 +7 more
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肾透明细胞癌差异表达基因的筛选及其核心基因相应miRNA和lncRNA预测分析 [PDF]
, 2018 【目的】筛选肾透明细胞癌(ccRCC)中差异表达基因并其相关miRNA和lncRNA,寻找可作为ccRCC诊断及治疗的生物标志物。【方法】通过从TCGA数据库和GEO数据库筛选ccRCC差异表达基因并取交集,对差异表达基因进行GO功能分析和KEGG通路富集分析,使用MCODE软件筛选出差异表达基因中的核心基因,并利用mirDIP数据库和STARBASE数据库对核心基因上游的miRNA和lncRNA进行预测。【结果】共筛选出427个差异表达基因,这些差异表达基因在GO功能分析上主要与催化活性 ...
朱合欢 +5 more
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Research progress in the treatment of bladder cancer based on nanotechnology [PDF]
, 2023 Bladder cancer is the most common malignant tumor in the urinary system. Currently, the clinical treatment options for bladder cancer mainly include surgery, chemotherapy, radiotherapy, immunotherapy, targeted therapy, photodynamic therapy, combination ...
CAO Xiangqian +5 more
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Ameliorative effects on osteoporosis of small extracellular vesicles derived from bone marrow mesenchymal stem cells [PDF]
, 2023 Objective·To investigate the effects of small extracellular vesicles (sEVs) derived from human bone marrow mesenchymal stem cells (BMSCs) on the regulation of osteoclast differentiation and macrophage polarization in mice, and mouse model of osteoporosis.
GUO Shangchun, LI Xuran, TAO Shicong
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微粒体在缺血性卒中的作用 The Role of Microparticles in Ischemic Stroke
Zhongguo cuzhong zazhi, 2019 【摘要】 在血管内皮功能障碍、急慢性血管炎症和高凝状态下均可发现由血小板、白细胞和内皮细胞释放的微粒体。不同种类的微粒体在缺血性卒中病理过程中的作用有所不同：缺血性卒中患者外周血白细胞微粒升高，高水平的白细胞微粒体能加重血管内皮细胞损伤，血浆中长期及高水平的血小板微粒体可诱导微血管血栓形成。另外，不同种类的微粒体均能反映血管内皮损伤的程度，诱导内皮细胞功能失调，加重内皮功能障碍，同时微粒体中携带的信使RNA和微小核糖核酸等能促进内皮细胞增殖，促进动脉粥样硬化斑块内新生血管生成，使斑块更易破裂出血。
周蕾，吴冬雨，姚小梅，时彦莹，朱宪策，黄晶，王春雪，张宁
doaj +1 more source
Research progress of immune response regulated by epigenetic modification in pneumonia [PDF]
, 2023 Pneumonia is one of the most common infectious diseases, and although considerable progress has been made in the diagnosis and treatment of pneumonia, it is still associated with high mortality, prolonged hospitalization, and significant medical ...
HAN Xiao, WANG Qing, ZHANG Xiaobo
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Bibliometric Analysis of Forensic Genetics Literatures in SCIE from 1989 to 2019 [PDF]
, 2021 Objective To conduct bibliometric analysis of forensic genetics literatures published by Chinese mainland scholars in SCIE journals from 1989 to 2019, to show the research achievements of the past three decades and predict future research fields and ...
ZHANG Xing-ru, HE Yong-feng, ZHANG Yun-ying, et al.
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主动脉夹层患者血清中miR-20、miR-15a水平与预后关系
Zhongguo shiyan zhenduanxue, 2021 目的探究微小RNA-20(miR-20)、微小RNA-15a(miR-15a)在主动脉夹层患者血清中的表达水平及两者与预后的关系。方法选取2015年4月至2018年7月于本院确诊的109例主动脉夹层患者为研究对象,称患病组,并将同期106例健康体检者作为对照,为健康组。以实时荧光定量PCR法检查所有受试者血清中miR-20、miR-15a表达水平;分析两组不同预后患者一般资料及血清中miR-20、miR-15a水平;采用Logistic回归分析影响主动脉夹层预后的因素;利用受试者工作特征曲线(ROC ...
李亮 +6 more
doaj
, 2021 目的研究外泌体中糖尿病相关的微RNA（miRNA）在妊娠期糖尿病（GDM）孕妇血浆中的表达情况并探讨其与GDM发病机制的关系。方法本研究在基因表达汇编（GEO）数据库中检索到糖尿病相关的miRNAs芯片数据集，采用GEO2R筛选数据集中表达上调或下调的miRNAs，选取在2个或以上数据集中变化一致的miRNAs作为糖尿病相关的miRNAs。研究纳入孕龄在10~16周的单胎孕妇，随访至24~28周，根据口服葡萄糖耐量试验（OGTT）结果将其分为GDM组和正常糖耐量（NGT）组，采用实时定量RT ...
刘斌 +6 more
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Research progress on non-coding small RNA in oral submucosal fibrosis [PDF]
Oral submucous fibrosis (OSF) is one of the most common precancerous lesions of the oral mucosa, and its pathogenesis has not been fully elucidated. Small noncoding RNAs (SncRNAs), a class of RNA molecules that do not code for proteins, have been widely ...
PENG Hui, WU Yingfang
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