Results 21 to 30 of about 3,303 (156)
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, EarlyView.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
基于环境
Haiyang yu huzhao海山遍布大洋海底，由于其特殊海底地形和水文动力环境，孕育了丰富且特殊的生物群落。采用环境RNA技术分析西太平洋M4浅水海山区真核微生物的多样性和分布，并与环境DNA技术检获的结果进行比较，揭示二者的异同。研究发现，RNA和DNA技术检获的表层和DCM层群落结构相似，在200 m以深的水层中群落结构差异较大。共甲藻纲的相对丰度在DNA数据中占比高于RNA数据，因此可能被基于eDNA的技术高估；而甲藻纲和金藻纲则相反，存在被低估的可能性。通过真核微生物与细菌的共现网络 ...
尹 婷婷 +3 more
doaj +1 more source
Advances in epigenetic mechanisms of lead toxicity [PDF]
Lead is a ubiquitous toxic heavy metal and one of the earliest and most widely used heavy metal elements in human history. Due to its non-degradable nature in the environment and its long biological accumulation effects (lasting up to 30‒50 years) in the
YAN Chonghuai, ZHANG Xinxin
core +1 more source
Rare Metals, EarlyView.ABSTRACT This study introduces novel nonequiatomic TiZrCoCrMoCux (x = 0, 5, 10; at%) medium‐entropy alloys (MEAx) tailored for orthopedic implants, synergistically combining the biocompatibility of Ti‐based alloys, the wear resistance of CoCrMo alloys, and the antibacterial/osteogenic attributes of Cu. The alloy's microstructure, mechanical properties,
Hang Yu +9 more
wiley +1 more source
Rare Metals, EarlyView.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Rare Metals, EarlyView.ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang +14 more
wiley +1 more source
Methods in Ecology and Evolution, EarlyView.Abstract DNA barcode‐based species identification has become pivotal in biodiversity research. Current barcoding‐based deep learning methods have advantages in species identification but exhibit significant limitations. By using COI barcoding alone, previous studies were unable to fully capture species identification features. Prior methods showed that
Bin Ye +4 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的探讨膀胱癌中微小RNA-21和肿瘤抑素表达与临床病理特征之间的关系。方法采用SABC法对98例膀胱癌患者分别进行微小RNA-21和肿瘤抑素的免疫组化染色,其与肿瘤临床分期和细胞分级间的关系及微小RNA-21和肿瘤抑素在瘤细胞中的共表达情况。结果膀胱癌患者中微小RNA-21和肿瘤抑素的阳性表达率分别是69.4%和43.9%。与浅表性和分化较好的膀胱癌相比,侵袭性和分化差的癌细胞中微小RNA-21表达上调明显,而肿瘤抑素表达则显著下调,组间比较 ...
李然伟 +5 more
doaj
Genomic responses to increased temperature and pollinator selection in Brassica rapa L.
New Phytologist, EarlyView.Summary Rapid environmental change reshapes both abiotic stress and biotic interactions, yet it remains unclear how these combined forces structure plants' genomic adaptation. In particular, the joint influence of temperature and pollinator identity, two ecological axes undergoing simultaneous global shifts, has rarely been quantified at genomic ...
Yanqian Ding, Florian P. Schiestl
wiley +1 more source
Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source