Results 31 to 40 of about 3,303 (156)
Zhongguo shiyan zhenduanxue, 2018 微小RNA（miRNAs）是一类内源性的高度保守的非编码蛋白质的单链小分子RNA。它们通过与靶基因结合,在转录后水平导致靶mRNA的翻译抑制或降解,调节靶基因的表达[1]。微小RNA-92（miR-92）是近年来发现的一种新型miRNA ...
郭凤军, 邹颖刚, 李丹, 田静岩
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Veterinary Dermatology, EarlyView.ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann +2 more
wiley +1 more source
胃癌患者血清中miR-204水平变化及与幽门螺杆菌感染的关系
Zhongguo shiyan zhenduanxue, 2017 幽门螺杆菌（Hp）感染已经被国际癌症研究机构列为第一类癌病致病原[1]。目前大量研究已证实Hp感染与胃癌发生、发展密切相关,但具体机制尚不清楚。微小RNA（miRNA）是一种单链RNA,目前研究认为其具有非编码性和高度保守性[2]。Calin[3]研究发现有超过半数的miRNA的基因所在区域与肿瘤有关,诸如杂合子缺失的微小区域 ...
周保贞 +3 more
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Advanced Science, Volume 13, Issue 3, 14 January 2026.Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng * +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2002 新近发展的组织微阵列 /芯片技术是将多个细小组织片整齐排列于同一载体而成的缩微组织切片 ,具有体积小、信息含量高的特点。适于免疫组化和DNA、RNA原位杂交 ,并能大大提高实验效率 ,而且可根据需要灵活设计 ,所得结果均一可靠、可比性强。近年来多项研究表明组织微阵列 ...
杨琳, 李锦毅, 郑华川
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
China-Australia Science and Technology Forum 2010 [PDF]
, 2010 This presentation was originally in Chinese. The following is only a brief description. From metazoan to mammals, the number of protein coding genes and functional scope are broadly similar, about two million, and the functions of these genes encoding ...
Liu, Guang Bin
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Veterinary Dermatology, Volume 36, Issue 5, Page 668-678, October 2025.Background – Erythemato‐ceruminous otitis externa (ECOE) is commonly associated with Malassezia spp. and microbial imbalance. Hypothesis/Objective – To assess the clinical performance of an ear cleaner in dogs suffering from ECOE associated with Malassezia spp. overgrowth and to measure its impact on the microbiota. Conclusions and Clinical Relevance –
Amaury Briand +11 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2020 胶质瘤(glioma)是起源于脑部或脊髓的神经系统肿瘤,根据组织细胞形态学特征可分为不同的亚型。胶质瘤组织病理学分类仍存在较大异质性,同一病理类型患者其分子学改变、病程演进、治疗反应等仍不尽相同[1]。因而,深入研究胶质瘤的分子病理机制是近年的研究热点之一。微小RNA(micro RNAs,miRNAs)为长度19-22个核苷酸组成的非编码RNA,通过与靶基因信使RNA结合,进而调控基因的转录后表达 ...
董阳, 李世星, 邵艳春
doaj
Lentivirus production by HEK 293T cell lines using two sites of SIPI/EDG-I gene in chicken [PDF]
, 2010 RNA干扰的发现是近十年生物学上最重要的发现。RNA干扰是指动植物体内由与被沉默的基因同源的双链RNA诱发的、具有序列特异性的、转录后基因沉默的一个过程。 RNA干扰目前已成为一种出色的运用在脊椎动物体上抗病毒技术。尽管在多数研究中采用外源短链干扰RNA(siRNA)来抑制病毒复制，然而最有效的是能在修饰过的内源微RNA(miRNA)存在的情况下表达短链发卡RNA(shRNA-mirs)的载体。这些载体已在活体中得到了运用。 本研究中，通过病毒注射或病毒感染HEK293T细胞株发育而来的鸡胚胎成纤维细胞，
KARAMO TOURE
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