Results 11 to 20 of about 706,680 (160)
Zhongshan Daxue xuebao. Yixue kexue ban, 1992 用抗补体免疫荧光法检测鼻咽癌患者和对照人群中EB病毒核抗原-1(EBNA-1)和EB病毒核抗原-2(EBNA-2)抗体的水平。鼻咽癌组中两种抗体滴度都升高,以EBNA-1抗体上升明显;且EBNA-1抗体与总EBNA抗体水平的变化趋势相一致。鼻咽增生性病变组中EBNA-2抗体略占优势,该组中EBNA-2抗体水平升高可能与潜伏状态的EB病毒激活或再感染的早期阶段有关。
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, 2019 单克隆抗体因其与抗原结合具有高度特异性与强亲和力,已成为抗体药物研发的主要类型。但随着天然单克隆抗体的深入研究,它的诸多缺陷也浮出水面,如与抗原结合次数有限、带来非预期的抗体清除效应和抗原累积效应。人们不再局限于天然抗体的筛选,而是想通过改造提升抗体药物的药效。近年来,一类新型再循环抗体的问世,很好地解决了天然单克隆抗体发展的瓶颈。再循环抗体可以在胞外结合抗原,在细胞内与抗原解离,使抗体结合抗原次数最大化,减少抗原介导的抗体清除效应和抗体介导的抗原累积效应 ...
陈远志, 罗文新, 温灿
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一种抗对虾白斑综合症病毒(WSSV)线性抗原表位单链抗体的筛选
, 2008 对虾白斑综合症病毒(WSSV)是全世界对虾养殖业最主要的病原体之一,虽然对该病毒的研究已较为深入,但目前仍无有效的防治方法。本研究应用噬菌体展示技术,构建了抗变性WSSV的单链抗体噬菌体展示文库,分别以WSSV病毒粒子和原核表达的囊膜蛋白VP28为靶分子对该文库进行淘选。经过数轮淘选后,得到5个能特异识别WSSV的单链抗体,且首次获得了能特异识别WSSV线性抗原表位的单链抗体P75E8。并通过免疫胶体金电镜分析,对5种单链抗体对应在病毒粒子上的表位进行了定位 ...
戴和平 +4 more
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PLANTS, PEOPLE, PLANET, EarlyView.Traditional Chinese Medicine has expanded far beyond Asia, with growing markets in North America and Europe for supplements and functional foods. Lingzhi or Reishi (Ganoderma lingzhi), a well‐known medicinal mushroom, is valued for its anti‐inflammatory and anticancer properties.
Torda Varga +8 more
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Mixed‐Scale Powder Enables 3D Printing of Tungsten Alloy
Rare Metals, Volume 45, Issue 11, November 2026.ABSTRACT Laser powder bed fusion (LPBF) offers a promising route for manufacturing tungsten alloy components with complex geometries, whereas W–Ni–Fe alloys remain the most widely used tungsten alloys because of their excellent overall performance.
Jingjia Sun +3 more
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Rare Metals, Volume 45, Issue 11, November 2026.ABSTRACT A thermomechanical strategy based on rolling‐annealing cyclic (RAC) was developed to regulate defect architecture and precipitation behavior in a (FeCoCrNi)94Al3Ti3 high‐entropy alloy. Intermediate annealing during rolling enables progressive grain refinement and introduces a high density of twins, stacking faults, and dislocations, forming a ...
Jiale Man +6 more
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Rare Metals, Volume 45, Issue 11, November 2026.ABSTRACT Biodegradable magnesium alloys are limited in orthopedic applications due to their rapid corrosion and poor interfacial stability. In this work, a composite coating is constructed via magnetic filtered cathodic vacuum arc (MFCVA) deposition of a Zn interlayer, followed by hydrothermal in situ generation of ZnO to induce hydroxyapatite (HA ...
Chao Zhang +9 more
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GHK‐Cu Delays Aging Through the Repair of Mitochondrial Dysfunction
Rare Metals, Volume 45, Issue 11, November 2026.ABSTRACT Althugh glycyl‐L‐histidyl‐L‐lysine copper (GHK‐Cu) shows antiaging potential, its precise molecular mechanisms remain unclear. Using Caenorhabditis elegans (C. elegans) as an in vivo aging model, we observed that GHK‐Cu extended organismal lifespan and improved stress resilience.
Haoquan Yu +8 more
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Rare Metals, Volume 45, Issue 11, November 2026.ABSTRACT To address the insufficient wear resistance of high‐entropy alloy (HEA) coatings under extreme conditions, FeCoNiCrCu and FeCoNiCrCuB0.03Si0.03 microalloyed coatings were fabricated via annular oscillating laser deposition. This work systematically investigated the effects of synergistic B/Si addition on their phase composition, microstructure,
Tao Wang +6 more
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, 2003 本文研究了作用力对TNF-α抗原/抗体二维反应的影响,结果表明,TNF-α抗原/抗体间的解离力满足正态分布,而非定值,且不同的作用力,回拉速率和接触时间影响抗原 ...
李宝霞, 龙勉, 叶志义
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