Results 1 to 10 of about 2,142 (98)
NMR联用HILIC-UPLC-MS/MS测定TNBS诱导的结肠炎大鼠尿液和血浆代谢物变化 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的基于非靶标和靶标代谢组学技术，探讨三硝基苯磺酸（TNBS）诱导的结肠炎模型大鼠尿液以及血浆中内源性代谢物的变化。方法16只雄性SD大鼠随机分成对照组和模型组，每组8只，对模型组大鼠给予TNBS灌肠以建立实验性大鼠结肠炎模型。利用核磁共振氢谱（1H NMR）检测两组大鼠尿液代谢物，同时联用HILIC模式超高效液相色谱串联三重四级杆质谱（HILIC-UPLC-MS/MS）测定以上大鼠尿液以及血浆中氨基酸水平，并通过多元变量统计方法对代谢组学数据进行分析。结果同对照组相比，1H ...
刘雯 +7 more
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Zhongguo cuzhong zazhi针灸作为传统医学的重要组成部分，近年来在缺血性卒中治疗中的机制受到广泛关注。本文对针灸通过干预脑-肠轴治疗缺血性卒中的相关基础研究进行汇总分析，发现其可能涉及以下机制：其一，调节肠道菌群组成，抑制致病菌增殖并促进有益菌定植，同时增强肠上皮紧密连接蛋白表达以维持肠道屏障功能，减少肠源性毒素入血；其二，通过神经内分泌调控抑制下丘脑-垂体-肾上腺轴过度激活，降低促炎因子释放，并激活迷走神经介导的抗炎通路；其三，调节短链脂肪酸、氧化三甲胺等肠道菌群代谢产物的动态平衡，改善全身炎症微环境；其四 ...
赵乾坤1，2，李宪东2，徐天策2，陈会生1，2 (ZHAO Qiankun1,2, LI Xiandong2, XU Tiance2, CHEN Huisheng1,2 )
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Correlation Study between Serum Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke [PDF]
, 2022 BackgroundAssessment of the risks of stroke and then initiation of primary prevention are crucial to reducing the incidence rate of stroke. Trimethylamine-N-oxide (TMAO) is a recently discovered intestinal microbial metabolite, whose relationships with ...
LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun
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Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus [PDF]
, 2023 The global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation.
FANG Zichen +5 more
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Advances in the Mechanism and Regulation of Obesity Induced by Gut Microbiota [PDF]
, 2023 The global prevalence of obesity has nearly tripled in the past 40 years and continues to rise at an alarming rate. High fat and high carbohydrate diets can cause gut microbiota disturbance and impairment of intestinal barrier function in obese ...
YU Miao, XU Jinzhao, YANG Xiaoying, MA Longkai, YU Yansong, NING Ke, XIE Qinggang, XU Xiaoxi
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Advances in fundamental and translational breast cancer research in 2022 [PDF]
, 2023 According to the data released by the International Cancer Research Institute of the World Health Organization (WHO), breast cancer is the malignant tumor with the highest incidence rate in women, and seriously endangers women's health.Many impressive ...
WANG Ziyu, XIAO Yi, JIANG Yizhou, SHAO Zhimin
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Zhejiang Daxue xuebao. Lixue ban, 2007 以过硫酸铵和季戊四醇为氧化还原引发体系引发丙烯酰胺(AM)与甲基丙烯酰氧乙基三甲基氯化铵(DMC)自由基共聚合，采用FTIR和1H-NMR进行结构表征.研究了引发剂用量、单体配比及浓度对星形阳离子型聚丙烯酰胺共聚物特性粘数及阳离子度的影响，并用于处理高岭土废水，其絮凝效果明显优于相应的均聚物及线形共聚物.
ZHENGBao-qing(郑宝庆) +1 more
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Application Prospects and Prospect of Metabolomics in the Identification of Sudden Cardiac Death [PDF]
, 2021 In cases of sudden death, the prevention of sudden cardiac death and the analysis of the cause of death after sudden cardiac death have always been a difficult problem.
GU Zhen, NIU Jia-jia, AN Guo-shuai, et al.
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Zhejiang Daxue xuebao. Lixue ban, 2008 采用等转化率法研究了2， 4， 6-三（羟基苯甲基氨基）-均三嗪(MFP)与双酚A型环氧树脂(DGEBA)在等温和非等温条件下的固化反应行为，两种条件下MFP/DGEBA固化反应的表观活化能（Eα）均随转化率(α)增加呈先减后增的趋势（α= 0.25时取得最小值）.由于仲胺基和酚羟基对环氧基反应的不等活性，非等温固化反应时两种反应先后发生，形成Triazine-NCH2-CH(OH)-结构后，再形成ArO-CH2-CH(OH)-结构并产生交联，前后两阶段Eα分别为69.8、86.8 kJ • mol-1.
ZHANGXing-hong(张兴宏) +2 more
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Zhejiang Daxue xuebao. Lixue ban, 2006 合成了一种含氮固化剂2，4，6-三（羟基苯基亚甲基胺）-均三嗪(MFP)和两种结构不同的含磷环氧树脂(FD、ED), 经红外光谱、核磁共振和元素分析等表征，证实了其化学结构.用MFP固化FD和ED制得了新型无卤阻燃的环氧树脂.用DSC测定了固化物玻璃化转变温度（Tg)，用TGA表征了其热性能，UL-94垂直燃烧试验表征了其阻燃性能.结果表明，所得含磷氮的无卤阻燃环氧树脂具有较高的玻璃化转变温度，优良的热稳定性，初始分解温度高达300 ℃以上，在850 ℃下的残炭率达到了27%以上，阻燃性能均达到了 UL-
MINYu-qin(闵玉勤) +3 more
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