Results 11 to 20 of about 2,142 (98)
Zhejiang Daxue xuebao. Lixue ban, 2008 2-苄硫基-5，7-二甲氧基-1，2，4-三唑并[1，5-a]嘧啶（Ⅲ）是磺草唑胺(metosulam)及1，2，4-三唑[1，5-a]嘧啶醚类超高效除草剂的重要中间体.由5-氨基-3-苄硫基-1，2，4-三唑(Ⅰ)为起始原料，经环合、氯代一步反应制得2-苄硫基-5，7-二氯-1，2，4-三唑并[1，5-a]嘧啶（Ⅱ).优化试验发现90 ℃、丙二酸与(Ⅰ)摩尔比为1.1：1、反应20 h时收率达85%以上.（Ⅱ)与甲醇钠进行置换反应制得(Ⅲ)，对反应温度和物料配比进行了优化试验，发现25 ℃、甲醇钠与 ...
SUNGuo-xiang(孙国香) +4 more
doaj +1 more source
Research Progress in the Formation and Regulation of Fish Soup Flavor [PDF]
, 2023 Fish soup, a traditional Chinese broth food, is loved by consumers due to its rich nutrition, high digestion and absorption rate, umami and sweet taste, and strong aroma.
WU Yanni, AN Yueqi, XIONG Shanbai
core +1 more source
Progress in Understanding the Relationship between Diabetes and Host Intestinal Microbiota and Diet-Mediated Microbiota Regulation [PDF]
, 2023 Diabetes is a metabolic disease characterized by insulin secretion disorder. When serious, it can cause various complications (cardiovascular and cerebrovascular diseases, cataract and other eye diseases, kidney disease and cancer), bringing a huge ...
WANG Danping, XU Jinzhao, ZHANG Xiaohang, NING Ke, LIU Ye, XU Yuanzhi, XIE Qinggang, XU Xiaoxi
core +1 more source
Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy [PDF]
Objective·To investigate the effects of trimethylamine oxide (TMAO) on cardiac function in mice with hypertrophic cardiomyopathy (HCM) and its potential molecular mechanism.Methods·Mice with myosin heavy chain 6 (Myh6) c.1211G>A (p.R404Q+/-) point ...
CHEN Hanzhang +8 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2020 氧化三甲胺(TMAO)是在人体摄入富含胆碱、左旋肉碱、卵磷脂等高脂营养物质后经肠道微生物转化后生成三甲胺(TMA),而后在肝脏的作用下生成的一种小分子化合物[1]。有相关研究表明,心血管疾病及不良心血管事件的发生与TMAO的产生、代谢过程相关,因此TMAO或可作心血管疾病诊断及治疗的潜在靶点[2,3]。本文就TMAO的生物学特性及其与心血管疾病的联系进行综述。
吴箴言 +5 more
doaj
乳腺癌是女性最常见的癌症之一，严重威胁女性健康。早期诊断和精准化治疗乳腺癌有助于改善患者预后。本文总结了细菌及其代谢物对乳腺癌发展与治疗的研究现状，详细探讨了细菌及其代谢物在乳腺癌发展及干预中的作用与机制。这些机制包括调控炎症和免疫反应、损伤DNA以及调控细胞生物学特征等。工程菌因其在靶向肿瘤和激活免疫方面的天然优势，近年来已成为乳腺癌治疗领域的热点之一。本文进一步对工程菌在乳腺癌治疗中的研究进展进行了总结，旨在为制定靶向治疗策略及改善患者预后提供重要参考依据 ...
孙丹丹, 田国宝
core +4 more sources
Prediction value of serum TMAO on myocardial injury after PCI in patients with coronary heart disease based on decision curve analysis [PDF]
Objective To explope the predictive efficacy of serum trimethylamine N ⁃ oxide（TMAO）on myocardial injury after percutaneous coronary intervention（PCI）in patients with coronary heart disease. Methods A total of 200 patients with coronary heart disease who
CHEN Guixiu，GUO Cheng，HE Lin
core +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的为了解肿瘤医院院感情况及其变化趋势，探讨肿瘤专科医院感染防控重点策略。方法通过医院感染监测系统获取中山大学肿瘤防治中心2019~2021年医院感染质量控制指标数据，采用卡方检验和趋势卡方检验对指标变化进行分析。结果2019~2021年该院院感发生率分别为0.80%、0.78%和0.57%，逐年显著下降（P<0.001）。其中以手术部位和呼吸系统感染较常见，两部位占比分别是35.75%和31.08%。革兰阴性菌和真菌是主要病原体。多重耐药菌院感发生率逐年显著上升，从0.08‰上升至0.14‰（P&
黄丽华 +6 more
doaj
Zhongguo shiyan zhenduanxue, 2020 纤维化指各种有害刺激造成组织损伤后启动的修复机制,表现为过度、无序的间质内纤维结缔组织大量增生、细胞外基质增多、实质细胞减少,严重可致器官结构破坏和功能减退。探讨纤维化的发生机制对于有效延缓器官功能减退至关重要。研究表明,肠道源性毒素氧化三甲胺(TMAO)在器官纤维化进程中扮演着重要角色。基于目前最新研究,本文就肠道源性毒素TMAO与心肌纤维化、肾脏纤维化的关系及机制进行综述。
谢舜昀, 刘师辰, 李微, 崔文鹏
doaj
Impact of Choline Intestinal Metabolism on Gut Microbiota and Physiological Indicators of Host Homeostasis [PDF]
This study aimed to investigate the changes in trimethylamine (TMA) levels in cecal contents, intestinal microflora structure and physiological homeostasis indicators in mice receiving dietary supplementation of choline, dietary supplementation of ...
SONG Yu, WU Di, ZHANG Lu, WANG Ting, ZHANG Min, LI Qian
core +1 more source