Results 11 to 20 of about 16,442 (164)
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
wiley +1 more source
Highlights Mild acquired impaired thyroid hormone sensitivity was widespread among the general populations. Reduced thyroid hormone sensitivity was related with metabolic syndrome and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.
Fang Lv +6 more
wiley +1 more source
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
wiley +1 more source
Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source
Acute phase protein concentrations following serial procaine penicillin G injections in horses
Abstract Background Acute phase protein (APP) measurement is used to detect inflammation. Intramuscular (IM) injections could cause tissue injury and induce an acute phase response (APR). Objectives To evaluate the effects of IM procaine penicillin G (PPG) injections on APP concentrations in horses.
Danielle L. Gordon +5 more
wiley +1 more source
Evaluation and redesign of the primers for detecting nitrogen cycling genes in environments
Abstract A better understanding of how nitrogen (N) cycling genes are involved in ecological processes is one of the crucial areas of microbial ecology. Currently, most molecular biological techniques investigating N cycling genes in the environment heavily rely on the accuracy of the polymerase chain reaction (PCR) primers; however, their specificity ...
Zhujun Wang +12 more
wiley +1 more source
Synthetic microbial consortia with programmable ecological interactions
Abstract Central to the composition, structure and function of any microbial community is the complex species interaction web. But understanding the overwhelming complexity of ecological interaction webs has been challenging, owing at least partly to the lack of efficient tools for disentangling species interactions in natural or artificial microbial ...
Shuyao Li +8 more
wiley +1 more source
目的 探討全基因體定序 (WGS) 對兒童神經疾病的診斷率及治療影響。 方法 從 2016 年 1 月至 2019 年 12 月, 使用全基因體定序對疑似患有遺傳性神經疾病的兒科病人進行評估。符合條件的病人依其臨床表現型分為四組: 神經發展障礙病人、癲癇病人、神經肌肉疾病病人及運動障礙病人。我們描述全基因體定序的診斷率及經全基因體定序確診後對病人治療的影響。 結果 共有 214 例病人 (男性 128 例, 女性 86 例) 接受了全基因體定序檢測, 病人平均 (SD) 發病年齡為 13.8 (27.6) 個月, 範圍為 1 天至 15 年 5 個月, 接受全基因體定序檢測的平均 (SD) 年齡為 71.7 (58.9) 個月, 範圍從 8 天到 18 歲。 43.9 ...
李 秀芬, 遲景 上, 蔡 啟仁
wiley +1 more source
Study on the New Method for the Construction of P-N Bond [PDF]
磷酰胺酯是一类重要的有机中间体,含有磷酰胺酯结构的化合物具有广泛的生物活性,如抗菌、抗病毒、抗癌活性等。此外,其还可以应用于药物前体和阻燃剂等方面的研究。 早期合成磷酰胺酯最常用的方法是通过胺与磷酰卤反应来实现,但是这种方法不仅反应条件要求苛刻,而且需要前期处理剧毒的磷酰卤化合物。近几十年来,随着研究的不断深入,研究者们终于在合成磷酰胺酯的方法上取得了一系列的突破,但仍存在着一些不足之处。例如,Atherton-Todd法虽操作简便,但使用了计量的剧毒CCl4,在一定程度上又限制了该方法的广泛使用 ...
桑帅
core
ABSTRACT The electrocatalytic reduction of nitrate (NO3ER) has emerged as a promising strategy for mitigating NO3− ${{\text{NO}}_{3}}^{-}$ pollution in wastewater while concurrently producing value‐added ammonia; however, its process is significantly hindered by the lack of highly efficient and low‐cost electrocatalysts. Herein, we proposed several non‐
Xue‐Shi Song +5 more
wiley +1 more source

