Results 81 to 90 of about 8,323 (166)
Plant Biotechnology Journal, EarlyView.ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su +8 more
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Haiyang yu huzhao循环水养殖是水产养殖的重要发展方向，研究光照对循环水养殖系统中水产动物生长发育的影响对促进健康高效养殖具有重要意义。以日本对虾(Penaeus japonicus)为对象，设置0L∶24D、6L∶18D、12L∶12D、18L∶6D和24L∶0D五个光照周期组(L:光照, D:黑暗)，探究其对生长及血清生化指标的影响。结果显示，存活率(SR)以24L∶0D组最高，终重、增重率(WGR)和特定生长率(SGR)均以24L∶0D组最优(P<0.05)，12L∶12D组次之。血清生化指标中，6L ...
李 彬 +7 more
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Natural antisense transcripts (NATs) correspond to nearly 60% of annotated rice loci, however their functions are largely unknown. In this study, we characterise a rice cis‐NAT (NAT1850) that completely overlaps with a rice‐specific primary miRNA, pri‐miR1850.
Yang Shen +11 more
wiley +1 more source
Gaoya dianqi, 2013 2013年9月25日拍摄的正式投入运行的"皖电东送"浙江安吉变电站。1 000 kV安吉变电站是浙江省内第一个特高压站点,通过该变电站,皖电东送工程每年可向浙江年送电量近300亿kW·h。当日10时,1 000 kV"皖电东送"特高压输电工程正式投入商业运行。这是我国首条同塔双回路特高压交流输电工程,
doaj
[Management of COVID-19: the Zhejiang experience]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2020 Xu K +16 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu +7 more
wiley +1 more source
浙江大学学报. 医学版研究表明，铁代谢和铁死亡影响了髓系肿瘤的发生发展，可以作为其治疗靶点。铁代谢失调存在于多种髓系肿瘤中：急性髓系白血病的预后与铁代谢分子的差异表达相关；伴随铁过载的骨髓增生异常综合征患者预后不良；骨髓增殖性肿瘤常表现为缺铁和红细胞增多共存，可通过靶向铁调素进行治疗。髓系肿瘤细胞容易受到活性氧积累的影响而发生氧化损伤，具有铁死亡敏感性。在急性髓系白血病和骨髓增生异常综合征中，铁死亡均具有抗肿瘤作用；在慢性髓系白血病中，靶向铁死亡可以逆转伊马替尼耐药。本文综述了髓系肿瘤发生发展中铁代谢水平的特征 ...
王 雨涤 +3 more
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Effects of NaHCO3 Alkalinity Stress on Micropterus salmoides
Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.ABSTRACT To provide guidance for the actual cultivation of Micropterus salmoides in saline alkali environment, the effects of NaHCO3 alkalinity stress on enzymatic activity, tissue structure and gut microbiota were investigated. The experimental groups consisted of Group 1 (no NaHCO3 added), Group 2 (10 mmol/L NaHCO3 alkalinity) and Group 3 (30 mmol/L ...
Wen‐ping Jiang +7 more
wiley +1 more source
浙江大学学报. 医学版信使RNA（mRNA）疗法是一种将体外转录的mRNA递送至特定细胞，生成目标蛋白以治疗或预防疾病的生物技术。mRNA疗法离不开有效的mRNA递送系统，而脂质纳米粒（LNP）是目前临床应用最为广泛的一类mRNA递送载体。LNP由可电离脂质、两性磷脂、胆固醇和聚乙二醇化脂质四种脂质材料组成，可有效解决mRNA药物存在的体内稳定性较差、难以跨越体内多级生物屏障等难题，并能够针对肝脏、肺和脾脏等器官实现mRNA安全、高效和靶向递送。本文阐述了LNP四种脂质组分在递送mRNA中的作用，介绍了通过抗体修饰 ...
何 顺, 刘 帅
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Aerobic Exercise Ameliorates Adverse Vascular Remodeling in Diabetes via PDK1/FoxO1 Axis
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Reduced PDK1 expression in the carotid arteries of type 1 diabetic mice promotes abnormal FoxO1 expression, thereby inducing inflammatory responses and vascular remodeling. These phenotypes can be ameliorated by regular aerobic exercise. In vitro experiments further confirm that the PDK1‐FoxO1 signaling axis in a high‐glucose environment can induce ...
Xiang Xie +3 more
wiley +1 more source