泛凋亡与中枢神经系统疾病的研究进展（Research Progress on PANoptosis and Central Nervous System Diseases）
Zhongguo cuzhong zazhi泛凋亡（PANoptosis）是一种全新的炎症性程序性细胞死亡形式，由泛凋亡体（PANoptosome）复合物调控并激活，具有细胞焦亡、凋亡和坏死性凋亡的主要特征。泛凋亡在病毒、细菌、真菌感染性疾病中发挥自我防御功能，在炎症性疾病中则加重疾病损伤。本文介绍泛凋亡的定义及分子调控机制，探讨多种细胞死亡形式的串扰和关联关系，阐述泛凋亡在卒中、脑肿瘤、脓毒症相关性脑病、癫痫等中枢神经系统疾病中的作用机制，旨在为中枢神经系统疾病的临床治疗提供新思路。Abstract: PANoptosis, a novel ...
刘嘉，刘雪梅（LIU Jia, LIU Xuemei ）
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Kukoamine B regulates pyroptosis mediated by NLRP3/Caspase-1/GSDMD pathway to alleviate lipopolysaccharide-induced macrophage inflammation [PDF]
Objective To investigate the regulatory effect of kukoamine B (KB) on the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/Caspase-1/gasdermin D (GSDMD) pyroptosis pathway in human monocytic leukemia THP-1 cells induced by ...
HE Ping, KE Rui, NING Pu, YANG Shuanying
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Research advances Progress in mechanistic studies of renal fibrosis based upon regulatory cell death [PDF]
As a basic pathological feature at advanced stage of various kidney diseases, renal fibrosis (RF) is an important cause of kidney failure. It is characterized by an excessive accumulation of extracellular matrix (ECM), damage of renal tissue structure ...
Guang-ming Yin +5 more
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Zhongguo shiyan zhenduanxue, 2018 细胞焦亡是近年来发现的以促炎为特点的细胞程序性死亡,与多种疾病的发生、发展及预后相关。GSDM蛋白家族包括6个成员,可通过多种途径被半胱氨酸蛋白酶caspase切割,暴露其具有活性的N端,后者在细胞膜表面形成孔道,引起细胞肿胀,从而诱导细胞焦亡,最终参与炎症反应、恶性肿瘤及神经系统疾病的发生及发展,并对恶性肿瘤的治疗及预后产生影响。此外,GSDM家族蛋白的单核苷酸多态性(SNP)还参与多种免疫性疾病的发生。
吴珊 +6 more
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Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage [PDF]
Objective: To investigate the main component verbascoside (VB) in Osmanthus fragrans which inhibits NLRP3 inflammasome activation to improve inflammatory damage in BV-2 cells and its related mechanisms.
Fang CHENG +7 more
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Study on the mechanism of Boschniakia rossica polysaccharide inhibiting the activation of inflammasomes and pyroptosis in J774A.1 macrophages [PDF]
Objective: This study aimed to investigate the inhibitory effect of Boschniakia rossica polysaccharides （BRPS） on the activation of inflammasome and pyroptosis of J774A.1 macrophages induced by lipopolysaccharide （LPS） and adenosine triphosphate （ATP ...
JIN Aihua +3 more
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Research progress on the pathogenesis of acute lung injury in sepsis [PDF]
Sepsis is a systemic inflammatory response syndrome caused by severe infection leading to host dysfunction，often involving multiple organs and causing functional failure.
WANG Qin，YU Xu，LI Qingying，LU Yibin
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Zhongguo shiyan zhenduanxue, 2010 目的观察羟基喜树碱（HCPT）对前列腺癌PC-3m细胞凋亡的影响,初步探讨其作用机制。方法采用四甲基偶氮唑盐（MTT）法、流式细胞仪（FCM）及激光共聚焦显微镜（CLSM）检测细胞增殖与凋亡变化。结果HCPT作用后PC-3m生长明显受抑,且呈时间-浓度依赖性;在FCM及CLSM上可见凋亡率增加。结论HCPT体外能有效抑制前列腺癌细胞株生长;但其作用机制目前尚需进一步研究。
金光虎 +4 more
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Research progress of endoplasmic reticulum stress in peritoneal dialysis [PDF]
Peritoneal dialysis is an effective renal replacement therapy for the treatment of end-stage renal disease. Prolonged peritoneal dialysis is prone to peritoneal inflammation， neoangiogenesis， and fibrosis， ultimately leading to interruption of peritoneal
Li Yan-ling, Zou Xun-liang
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蛛网膜下腔出血病理生理机制研究进展 Advance in Pathophysiological Mechanism of Subarachnoid Hemorrhage
Zhongguo cuzhong zazhi, 2019 【摘要】 蛛网膜下腔出血（subarachnoid hemorrhage，SAH）是临床上常见的脑血管病急危重症，具有高致死率和高致残率的特点。尽管药物和血管内治疗不断进步，SAH患者功能预后的改善仍是目前面临的一大难题。现研究已表明SAH脑血管痉挛，氧化应激反应，炎症反应，血脑屏障破坏与脑水肿，细胞凋亡、焦亡与坏死，细胞自噬，皮质传播抑制和微血栓形成等病理变化过程是影响患者临床转归的潜在机制。本文就SAH病理生理机制进行综述，以期为SAH临床预防、治疗和药物研发提供参考依据。 【Abstract】
张昌林，倪小佳，林浩，吴俊标，李春花，黎劭学，蔡业峰
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