Results 21 to 30 of about 2,214 (157)
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
Translocation of Mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death [PDF]
, 2016 在最近的研究结果中，混交激酶域蛋白Mlkl(mixedlineagekinasedomain-like protein)被确认为Rip3蛋白在细胞坏死信号通路中的下游蛋白。然而，Mlkl如何 在细胞坏死信号通路中行使怎样的功能，尚未明晰。通过在Mlkl基因敲除的细 胞中回补Mlkl蛋白进行一系列的研究，实验数据表明，Mlkl蛋白氨基端结构域 是其在坏死通路中行使功能的必要部分。在坏死过程中，Mlkl蛋白形成多聚体； 或者在细胞中利用分子生物学手段人为地诱导形成Mlkl蛋白多聚体，也能够引 起细胞坏死 ...
李文娟
core
Glycyrrhizic acid attenuates cerebral ischemia-reperfusion injury in rats by inhibiting HMGB1-mediated pyroptosis [PDF]
Objective To explore the protective impact of glycyrrhizic acid on rats experiencing cerebral ischemia-reperfusion, and to elaborate its mechanism of action via high mobility group box-1 protein (HMGB1)- mediated pyroptosis.
CHEN Guolei +5 more
core +1 more source
, 2016 中国科协生命科学学会联合体:免疫细胞在病原菌的清除中发挥关键作用。病原菌入侵免疫细胞后能引起免疫细胞的炎性坏死即细胞焦亡(pyroptosis),这是机体的重要免疫防御反应,在清除病原感染和内源危险信号中发挥重要作用。细胞焦亡由炎性蛋白酶caspase介导,但具体机制完全未知 ...
韩家淮
core
Gasdermin D is an executor of pyroptosisand required for interleukin-1secretion [PDF]
, 2015 炎症小体是先天免疫系统中一类重要的胞内信号复合体。炎症小体的激活可以引发白介素1β（IL-1β）和白介素18（IL-18）的成熟和分泌，同时引发细胞焦亡。Caspase-1和caspase-11(人源同源蛋白caspase-4/5)分别在经典炎症小体和非经典炎症小体信号通路中起关键作用。本实验中，我们通过利用高灵敏度定量质谱技术，发现蛋白gasderminD（GSDMD）是炎症小体复合物的另一重要组成成分，它会随着NLRP3炎症小体激活剂的刺激进入炎症小体复合体。我们通过敲除GSDMD基因 ...
何琬婷
core
Research progress on influence of PM2.5 on allergic rhinitis [PDF]
, 2023 Allergic rhinitis (AR) is one of the main chronic inflammatory diseases that pose a global threat. Its symptoms persist for a long time, recur, and seriously affect the physical and mental health of the patients.
Huai WEI +4 more
core +1 more source
A small-molecule inhibitor B57 plays a role in the process of NLRP3 inflammasome activation [PDF]
, 2017 炎症小体是先天免疫系统中一类重要的胞内信号复合体。炎症小体的激活可以引发白介素1β（IL-1β）和白介素18（IL-18）的成熟和分泌，同时引发细胞焦亡。NLRP3炎症小体是迄今为止，研究最为广泛的炎症小体，它的上游刺激物性质各异，种类庞杂。研究表明，被激活的NLRP3向下游传递信号，依赖于模式识别受体对双接头蛋白ASC的招募，进而促使ASC在胞内形成大型蛋白复合体，激活炎症相关Caspase1。然而NLRP3招募相互作用蛋白ASC的过程，可能是其信号传递被调控的关键步骤 ...
郑振渊
core
高脂饮食诱导
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨高脂饮食引起的慢性炎症反应与阿尔兹海默病神经功能障碍之间的关系。方法12月龄C57BL/6J小鼠和APPswe/PS1ΔE9（APP/PS1）雄性小鼠，按体质量随机分为4组，正常组（C57BL/6J小鼠n=6）、普通高脂组（C57BL/6J小鼠+高脂饲料n=6）、痴呆组（APP/PS1小鼠n=6）、痴呆高脂组（APP/PS1小鼠+高脂饲料n=6）4组；普通饲料/高脂饲料喂养6周。每周监测小鼠体质量变化，免疫组化观察海马小胶质细胞激活情况，RT-qPCR检测海马炎性因子IL-1β、IL-6、TNF-
李泽 +6 more
doaj
A Screening to Find Protein Kinases Involved in MLKL-dependent Programmed Cell Death [PDF]
, 2017 细胞程序性死亡是细胞的一种基本生物学现象，由基因控制，自主而有序地发生。多细胞生物通过细胞程序性死亡的途径去除不需要的或异常的细胞。细胞程序性死亡有多种不同方式，细胞程序性坏死是其中之一。细胞程序性坏死由肿瘤坏死因子受体家族以及Toll-like受体家族启动，RIP1与RIP3是已知的通过相互作用传递死亡信号的蛋白激酶，RIP3是具有决定性作用的使细胞程序性坏死与其他有RIP1参与的信号通路相区分的转折关键性蛋白，而假激酶MLKL是RIP3的特异性底物蛋白。MLKL被RIP3磷酸化之后 ...
马欢
core
Physiological function of nerve injury-induced protein 1 and its role in relevant diseases [PDF]
, 2023 Nerve injury-induced protein 1 (NINJ1) is a cell-surface adhesion molecule containing an extracellular adhesion domain and two transmembrane domains. NINJ1 is named for its original discovery in damaged nerve endings.
LU Xinwu +4 more
core +1 more source