Results 21 to 30 of about 2,239 (121)
人重组骨形态发生蛋白7通过下调半胱氨酸蛋白酶-1/焦孔素D信号通路抑制高糖诱导的近曲小管上皮细胞的焦亡
Linchuang shenzangbing zazhi, 2023 魏凯悦 +5 more
doaj +1 more source
浙江大学学报. 医学版副黏病毒是一类重要的呼吸道病原体，在儿童感染性疾病中具有重要临床意义。其感染过程中可诱导多种形式的程序性细胞死亡（PCD），这些PCD形式在病毒复制、传播及宿主免疫应答中发挥关键作用，显著影响病毒的生命周期及疾病进展。一方面，PCD通过清除被感染细胞有助于限制病毒扩散并激活宿主免疫应答，从而增强抗病毒防御能力；另一方面，过度或异常的细胞死亡可能导致组织损伤和免疫紊乱，为病毒复制提供有利环境，进而加重病情。如细胞凋亡通过外源性与内源性通路参与感染控制，同时亦可能被病毒操控以增强其扩散能力 ...
刘 叶 +3 more
doaj +1 more source
低强度聚焦超声触发PLGA阿霉素在细胞内空化增加乳腺癌细胞死亡
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨低强度聚焦超声能否触发聚乳酸-羟基乙酸共聚物（PLGA）包裹阿霉素在细胞内的空化作用以增加4T1肿瘤细胞的死亡。方法采用双乳化溶剂蒸发法制备了负载阿霉素的聚乳酸-羟基乙酸共聚物（PLGA）纳米气泡。设立细胞内释药组，细胞外释药组，传统给药组，单独超声组和对照组。用流式细胞仪检测各组细胞的死亡情况，用细胞活力检测试剂盒（CCK8）检测各组的细胞增殖，细胞划痕检测各组的侵袭情况。结果超声组细胞核的红色荧光平均强度高于对照组，差异具有统计学意义（t=16.627，P<0.001）；聚乳酸 ...
黄盘辉, 罗琼, 严飞, 李绍林
doaj
A more‐than‐human political ecology of Indonesian songbird trade
Conservation Biology, Volume 40, Issue 3, June 2026.Abstract Since its inception, conservation science has considered wildlife trade a problem. In focusing on conservation outcomes, conservationists almost completely ignore the welfare of traded animals and plants and the harms they endure. We developed a political ecology approach that incorporates the interconnectedness of people with animals and ...
Sicily Fiennes +9 more
wiley +1 more source
Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou +6 more
wiley +1 more source
Explore the Mechanism of Morphological Differences between Pyroptosis and Necroptosis [PDF]
, 2017 细胞坏死和细胞焦亡是两种形式的程序性细胞死亡，均具有细胞质膜破裂的特征。在本文中，我们研究了细胞坏死和细胞焦亡的形态学差异及其机制。不同于细胞坏死，焦亡的细胞在细胞质膜破裂之前，细胞质膜上起泡并产生凋亡小体样的细胞突出物（将其命名为焦亡小体）。细胞质膜的破裂在坏死的细胞中是爆破样的，而在焦亡的细胞则为内容物缓慢释放，最终细胞变得扁平。细胞坏死是由其执行蛋白MLKL在细胞质膜上寡聚介导的，而细胞焦亡是由蛋白GSDMD被炎性caspase1或caspase11切割后介导的 ...
李敬贤
core
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]
, 2016 炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core
The role of TIFA in endothelial innate immunity
, 2017 類鐸受體所介導的NF-kappaB的激活是響應於助氧化和促炎性刺激的血管內皮細胞的一個主要的先天免疫反義。 我們確定了TIFA [TNFalpha receptor-associated factor（TRAF) interacting protein with a FHA damain]在血管內皮細胞中不但參與引發NLRP3炎症小體的誘導（信號1) 也參與了其活化（信號2)。我們首先發現氧化和炎性壓力如atheroprone流和高脂血症在in vitro及 in vivo實驗中皆能誘發與活化TIFA ...
Lin, Ting-Yang, 林庭揚
core +1 more source
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source