Results 41 to 50 of about 15,066 (234)
Highlights The association between stress hyperglycemia ratio (SHR) and long‐term outcomes was still controversial. Based on a large prospective multicenter cohort, we found that high SHR levels were independently associated with increased risk of major adverse cardiovascular events (MACE), all‐cause death, and unplanned revascularization. Associations
Guyu Zeng+18 more
wiley +1 more source
Highlights Transcutaneous oxygen pressure (TcPO2) could be used to assess microcirculation, which revealed endothelial injury. As endothelial injury is a cause of albuminuria in diabetic kidney disease (DKD), albuminuria and creatinine (ACR) might be employed to assess microcirculation in DKD patients in rural hospital where TcPO2 is not available. Our
Jin Sun+7 more
wiley +1 more source
Highlights All three estimated glomerular filtration rates (GFRs) (based on creatinine [eGFRcr], cystatin C [eGFRcys], or both [eGFRcr‐cys]) were more strongly associated with risk of all‐cause mortality among individuals with diabetes than among those without diabetes. Regardless of diabetes status, eGFRcys and eGFRcr‐cys were more strongly associated
Yu‐Jie Liu+10 more
wiley +1 more source
Abstract Many species are restricted to a marginal or suboptimal fraction of their historical range due to anthropogenic impacts, making it hard to interpret their ecological preferences from modern‐day data alone. However, inferring past ecological states is limited by the availability of robust data and biases in historical archives, posing a ...
Tom B. Letessier+8 more
wiley +1 more source
Abstract The Common Agricultural Policy (CAP) is the European Union's main instrument for agricultural planning, with a new reform approved for 2023–2027. The CAP intends to align with the European Green Deal (EGD), a set of policy initiatives underpinning sustainable development and climate neutrality in the European Union (EU), but several flaws cast
Ivon Cuadros‐Casanova+9 more
wiley +1 more source
Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen+6 more
wiley +1 more source
Clinical value of alpha-fetoprotein: alpha-fetoprotein-L3 isoform ratio and des-γ-carboxyprothrombin in early diagnosis of HBV-related hepatocellular carcinoma [PDF]
Objective To evaluate the value of different combinations of alpha-fetoprotein (AFP), alpha-fetoprotein-L3 isoform ratio (AFP-L3%) and des-γ-carboxyprothrombin (DCP) for early diagnosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC ...
Duan Jianping, Du Lei, Song Ting, Liu Zhensheng
core +1 more source
Clinical implication of PD-L2 in the prognosis assessment of HNSCC immunotherapy [PDF]
Background and purpose: Programmed death-1 (PD-1) monoclonal antibody therapy plays an increasingly important role in the treatment of head and neck squamous cell carcinoma (HNSCC).
HUANG He, JU Houyu, YANG Wenyi, YAN Ming, REN Guoxin, HU Jingzhou
core +1 more source
Advances in the role of circular RNA in schizophrenia [PDF]
Schizophrenia is a complex and severe mental disorder, the precise cause of which remains unknown. Circular RNA (circRNA), a type of non-coding RNA with a loop-like structure, is abundant in eukaryotic cell transcriptomes. Recent advancements
FU Lirong, ZHANG Chen
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NMR联用HILIC-UPLC-MS/MS测定TNBS诱导的结肠炎大鼠尿液和血浆代谢物变化 [PDF]
目的基于非靶标和靶标代谢组学技术,探讨三硝基苯磺酸(TNBS)诱导的结肠炎模型大鼠尿液以及血浆中内源性代谢物的变化。方法16只雄性SD大鼠随机分成对照组和模型组,每组8只,对模型组大鼠给予TNBS灌肠以建立实验性大鼠结肠炎模型。利用核磁共振氢谱(1H NMR)检测两组大鼠尿液代谢物,同时联用HILIC模式超高效液相色谱串联三重四级杆质谱(HILIC-UPLC-MS/MS)测定以上大鼠尿液以及血浆中氨基酸水平,并通过多元变量统计方法对代谢组学数据进行分析。结果同对照组相比,1H ...
刘德亮+7 more
core +1 more source