Results 31 to 40 of about 37,492 (172)

Analysis of the immunomodulatory properties of mycobacterium cell wall fraction on the cytokine production of peripheral blood mononuclear cells of healthy dogs

open access: yesVeterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.
Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward   +9 more
wiley   +1 more source

肾移植受者外周血白细胞CMV 抗原阳性细胞数及意义

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2001
【目的】探讨肾移植受者外周血白细胞巨细胞病毒(CMV)PP-65 抗原阳性细胞数的变化及意义。【方法】用免疫 细胞化学法检测外周血白细胞CMV-PP65 抗原, 术后头3 个月每周1 次。【结果】273 例肾移植受者中124 例术后检出CMVPP65 抗原阳性, 初次检出CM V-PP65 抗原的平均时间为(24.1±11.3)d, 每5 万白细胞中CMV 抗原阳性细胞数均值为7.1 ±5.8 , 其中5 例CMV 抗原阳性细胞数超过10/ 5 万白细胞。无症状性和症状性CMV ...
许元文, 毛海萍, 梁艳冰
doaj  

Experimental Study on the Effects of Ciji Hua’Ai BaoSheng Decoction on Cytokines of Tumor Chemotherapy Model Mouse with H22 Hepatoma Carcinoma Cells [PDF]

open access: yes, 2015
背景:癌症是一类严重危害人类生命健康的致死性疾病。化疗(Chemotherapy)是癌症临床治疗的经典方法之一,但化疗药物无选择性杀伤肿瘤细胞的同时,也杀伤正常细胞,带来较严重的副作用,严重影响患者生存质量及预后。慈济化癌保生汤(CHBF)是导师王彦晖教授临床多年诊治癌症所创立的经验方,该方用于癌症患者化疗后的长期调理,具有提高生存质量,改善体质、降低复发率及延长生存期的作用。前期研究证实[1]:慈济化癌保生颗粒能延长移植瘤和腹水瘤化疗模型小鼠的生存期,有一定的抑制化疗后移植瘤生长的作用 ...
GUAN JIE LOY
core  

Development of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance

open access: yesRare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.
Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man   +7 more
wiley   +1 more source

恶性血液病患者CD54表达及其与临床特征、疗效的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】探讨细胞间黏附分子-1(CD54)在恶性血液病的表达。【方法】用免疫荧光方法检测19 例急性髓系白血 病, 34 例急性淋巴细胞白血病, 10 例慢性粒细胞白血病, 15 例多发性骨髓瘤, 21 例非霍奇金淋巴瘤和16 例正常人骨髓单个核 细胞表达CD54 。【结果】①除多发性骨髓瘤、慢性粒细胞性白血病外, 急性髓性白血病细胞、非霍奇金淋巴瘤、急性淋巴细胞 白血病患者骨髓单个核细胞表面CD54表达低于正常人。②CD54在急性早幼粒细胞白血病(M3)表达高于在其它类型急性髓 ...
童秀珍   +5 more
doaj  

The spectrum-effect relationship study on Tripterygium Wilfordii glycoside tablet based on therapeutic effect and toxicity [PDF]

open access: yes, 2015
雷公藤多苷片是由雷公藤的干燥根提取、纯化制得的,具有良好的抗炎、免疫抑制的药理作用,临床上广泛用于治疗类风湿关节炎、肾病综合征等疾病,疗效确切。但临床不良反应高发,且临床应用表明不同厂家的雷公藤多苷片药效和毒副反应有较大差异。由于雷公藤化学成分复杂,多个成分既为有效成分又为毒性成分,而目前多仅对雷公藤甲素(雷公藤内酯醇)或雷公藤内酯甲进行含量控制,无法全面的对雷公藤多苷片的药效和毒性进行控制。明确药效成分和毒性成分,建立全面科学、符合中药制剂整体起效特点的质量控制方法,是当前研究的热点和难点 ...
池婕
core  

Update on the role of cytokines and chemokines in canine atopic dermatitis

open access: yesVeterinary Dermatology, Volume 35, Issue 1, Page 25-39, February 2024.
Background – Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD. Objectives – To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the ...
Chie Tamamoto‐Mochizuki   +6 more
wiley   +1 more source

磷酸氯喹对白血病细胞株的影响

open access: yesZhongguo shiyan zhenduanxue, 2011
目的本实验以药物磷酸氯喹干预白血病细胞株,观察其对白血病细胞生长凋亡的影响,同时研究用药后凋亡相关蛋白Pnas-2的变化,以探寻磷酸氯喹作用白血病细胞株机制。方法 MTT法检测药物干预后白血病细胞增长情况;AnnexinⅤ/sytox标记细胞以流式细胞仪检测药物干预前后细胞凋亡情况的差别;激光共聚焦观察蛋白Pnas-2的亚细胞定位,蛋白印迹实验检测药物作用前后,Pnas-2表达量的变化。结果 50μg/mL的磷酸氯喹能够诱导白血病细胞株凋亡。并发现凋亡相关蛋白Pnas ...
刘佳   +6 more
doaj  

Holliday交叉识别蛋白在肾细胞癌中的表达及意义

open access: yesZhongguo shiyan zhenduanxue, 2020
目的观察肾细胞癌中Holliday交叉识别蛋白基因和蛋白表达的改变。方法肾癌A498细胞、os-rc-2细胞作为实验组,人肾小管上皮细胞HK2作为对照组,实时荧光定量聚合酶链反应分析Holliday交叉识别蛋白在实验组和对照组的基因表达情况,蛋白印迹分析其蛋白表达情况。结果与对照组人肾近曲小管上皮细胞HK2细胞相比较,os-rc-2和A498肾癌细胞中Holliday交叉识别蛋白基因和蛋白表达水平均明显下降 ...
原江水   +3 more
doaj  

Molecular mechanism of inhibitory effect of lipoxin A4 on estrogen-induced epithelial to mesenchymal transition (EMT) in endometriosis [PDF]

open access: yes, 2016
子宫内膜异位症,简称内异症(Endometriosis,EM),是育龄妇女的常见病,它是指具有活性的子宫内膜出现在子宫腔以外所引起的一种病变。人群发病率高达10%-15%。其典型症状为不孕和疼痛,严重影响患者的生活质量和家庭和谐,尤其是高达50%的复发率,给家庭和社会带来沉重的经济负担。这一系列防治难题的根本原因在于发病机制尚不明确。解析内异症的发病机制,进而寻找新的药物靶点和安全高效的治疗方法具有重大意义。 本论文首先以临床内异症患者在位/异位子宫内膜组织及非内异症患者子宫内膜组织为研究对象 ...
吴荣锋
core  

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