Shanghai plan for early screening, diagnosis and treatment of colorectal cancer (2023 edition) [PDF]
Colorectal cancer is a common malignant tumor in China. At present, the incidence rate and the mortality rate of colorectal cancer in China are on the rise.
Colorectal Cancer Special Committee of Shanghai Anti-Cancer Association
core +1 more source
Integrative Conservation, Volume 4, Issue 3, Page 277-286, September 2025.This study provides an innovation to address the challenge in accessibility to samples and genetic markers in Snow leopard conservation genetic studies. We performed next‐generation sequencing (NGS) on 19 fecal samples obtained from the eastern Qinghai‐Tibet Plateau, and successfully assembled 17 complete mitogenome sequences (~16,720 bp) and ...
Chen Cheng +7 more
wiley +1 more source
Function and mechanism of Repulsive Guidance Molecule RGMb/Dragon during Colorectal Cancer progression [PDF]
, 2016 结直肠癌是我国甚至全球范围内最常见的肿瘤之一，也是肿瘤相关死亡的主要原因之一。及时而有效的诊断是降低结直肠癌死亡率的重要措施。除了临床上常规的诊断及治疗方法外，人们也在不断致力于新型肿瘤标志物的研究，以进一步明确结直肠癌发生发展的机制。排斥导向分子(RGM)家族成员RGMb，又名Dragon，作为骨形态发生蛋白(Bonemorphogeneticprotein，BMP)通路的辅助受体，不但承载着胚胎发生、神经修复和肾脏正常生理功能，还与各种上皮来源肿瘤的发生发展密切相关。然而，RGMb ...
施颖
core
Research of diagnostic biomarkers in Breast cancer and Gastric cancer [PDF]
, 2013 自生物标志物（biomarker）这一概念提出以来，肿瘤生物标志物（tumorbiomarker，TBM）在基础医学领域的研究已成为热点。本文基于大量的临床病理样本，利用免疫组织化学、甲基化芯片分析、实时荧光定量PCR等技术，研究乳腺癌、胃癌预后诊断的生物标志物，为疾病的治疗提供新的思路和靶点。 我们利用免疫组织化学，调查了酪氨酸磷酸酶Shp2和它的伴侣蛋白Gab2在141例乳腺浸润性导管癌中的表达，并分析了他们与临床病理学特征的相关性，发现Gab2蛋白表达与病人的年龄存在显著相关性 ...
陈宝珍
core
Research Progress on Microbial Source Tracking for Traceability of Pollution Sources in Food Chains [PDF]
Fecal microbial contamination in the food chain is a significant concern in the field of food safety as it is one of the most important pathways causing foodborne diseases.
FAN Lihua, WANG Jiangxue, OU Zongyuan, ZHANG Yanru, Zhang Luyao, LIU Shiyi, ZHOU Zimei, LI Guoliang
core +1 more source
野生动物学报, 2021 2018年3月—2019年1月，在卧龙国家级自然保护区三江片区和其他3个重要区域布设120个红外相机监测点对食肉动物（Carnivora）进行调查，以了解保护区内食肉动物的物种组成与垂直分布；依据粪便采样与DNA宏条形码分析，对粪便产生者及其食物种类进行鉴定，了解重要物种的食物组成和同域分布物种间的捕食关系。结果表明：在卧龙保护区共记录到13种食肉动物，其中分布海拔跨度最高的物种为猪獾（Arctonyx collaris），其次为豹猫（Prionailurus bengalensis）与黄喉貂 ...
金森龙 1# 瞿春茂 1# 施小刚 1 邹晓艳 1 刘俊 1 邵昕宁 2 +3 more
doaj
Using bar coded 454 pyrosequencing technology to study the structure of gut microbiota in patients with Nonalcoholic fatty liver disease [PDF]
, 2014 目的：非酒精性脂肪性肝病（nonalcoholicfattyliverdisease，NAFLD）及慢性乙型肝炎（ChronicHepatitisB，CHB）均是严重危害人类健康的常见病。大量临床研究表明肝病的发生发展常与人体肠道微生态的变化密切相关。本研究通过分析NAFLD及CHB并NAFLD患者与健康人的肠道细菌构成及数量之间的差异，以阐明NAFLD及CHB并NAFLD对肠道菌群结构的影响。 方法：本研究通过使用barcoded454测序技术，共对经临床病理确诊的47例NAFLD患者 ...
陈建能
core
Effect of gnetol on osteoporotic bone defect mice based on RANKL/RANK/TRAF6 and gut microbiota [PDF]
Objective To explore the potential mechanism of gnetol in the treatment of osteoporotic bone defects and its effect on the gut microbiota. Methods A total of 30 C57BL/6J mice were randomly divided into sham group, model group, alendronate sodium group ...
WEI Yuhang, ZENG Gaofeng
core +1 more source
Effects of Fermented Milk with Live Bifidobacterium lactis Y6 on Intestinal Health in People with Digestive Dysfunction [PDF]
To investigate the effects of administering fermented milk with live Bifidobacterium lactis Y6 on intestinal health in people with digestive dysfunction, a dietary intervention experiment was conducted. Volunteers with digestive problems were selected to
Chunchang TAO +4 more
core +1 more source
野生动物学报, 2015 粪便由于容易辨识来源,方便收集并且可以提供动物食性分析、肠道寄生虫、种群数量、群体遗传学方面的信息而成为野生动物非损伤性采样的主要方式而被广泛采用。在食性分析方面,使用粪便残渣,同位素分析,植物表皮烷类蜡质,近红外以及DNA条码技术,能够获得不易观察的动物的食性数据; 利用粪便中的寄生虫幼虫或虫卵可以调查野生动物肠道寄生虫侵染情况; 在种群数量统计方面,粪堆计数法由于简便而广被使用,另一种粪便种群研究方法是非损伤标记重捕法,该法虽然会受到DNA质量的困扰,但是由于可以获得家域 ...
周璨林 宁礼群 马合木提·哈力克
doaj