Results 11 to 20 of about 2,034 (122)
The Anatomical Record, Volume 306, Issue 12, Page 3214-3228, December 2023., 2023 Abstract The effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation.
Li‐Zhe‐Xiong Song +8 more
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Research progress in the relationship between mitochondrial dysfunction and osteoporosis [PDF]
, 2023 Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always
CHEN Yantong +4 more
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Recent advance in autophagy-related pathways and key biomarkers in major depressive disorder [PDF]
, 2023 Major depressive disorder (MDD) is a very common and severe mental disorder. Persistent emotional distress is one of its main clinical symptoms. The etiology of MDD is complex and highly heterogeneous, and has not yet been clarified.
HE Shen, LI Huafang, LI Siyuan
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自噬是一种高度保守的细胞自我调节机制，主要发生在哺乳动物和酵母细胞的溶酶体或液泡中，对维持生命活动及物质代谢的平衡至关重要。当细胞处于应激状态（如营养缺乏、物理化学刺激、感染、氧化应激等），或细胞质中积累了老化或受损的细胞器，自噬过程就会被激活，通过降解并循环利用受损的蛋白质和细胞器，清除潜在的有害物质，将降解产物用于能量供应和大分子的再合成，从而帮助细胞维持稳态。自噬激活剂是指能够促进细胞自清除过程的化合物或药物（如mTOR抑制剂、AMPK激动剂、SIRT1激活剂、溶酶体增强剂等 ...
侯宇, 赵英鹏
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Mitochondrial Damage due to Hypoxia and Its Forensic Significance [PDF]
, 2020 Mitochondria are the special organelle in eukaryotic cells. Their main functions are to synthesize energy required for cell activity by oxidative phosphorylation. Most of the oxygen absorbed by the body is consumed in the mitochondria.
HU Yi-kai, ZHANG Heng, XIAO Bi, et al
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Advances in Chinese medicine-mediated AMPK/mTOR signaling pathway for the treatment of osteoporosis [PDF]
, 2023 Osteoporosis （OP） is a systemic bone disease and a common orthopedic disorder in elderly patients. High morbidity， disability and mortality rates and medical cost of OP bring huge burden to the patients and their family.
Zhang Wenhao, Yi Lin, Xiang Wenyuan, Remira·Aimaiti, Deng Yingjie, Liao Jun, Liang Zhiquan, Li Leijiang, Fang Rui
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Food-Derived Natural Products Prevent Neurodegenerative Diseases by Regulating Mitophagy: A Review of Research Progress [PDF]
Neurodegenerative diseases are often characterized by progressive dysfunction and loss of neuronal structure and function, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. Mitochondria, the center of energy metabolism in the body,
CAO Yuxin, ZHANG Yanqing, QI Wuqin, XIE Junbo
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Influence of transient receptor potential cation channel 6 on renal tubulointerstitial inflammation in mice with diabetic kidney disease and its mechanism [PDF]
Objective To investigate the influence of transient receptor potential cation channel 6 (TRPC6) on renal tubulointerstitial inflammation in mice with diabetic kidney disease (DKD) and its mechanism. Methods A total of 36 male C57/BL6J mice, aged 6 weeks,
LIU Congcong, ZHANG Xingjian, DING Lin, ZHANG Yao, ZHANG Dongjie, MA Ruixia
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Function of Apoptosis and Autophagy in Cardiovascular Diseases [PDF]
, 2017 细胞凋亡与自噬是普遍存在于各种细胞内的生命现象,广泛参与了机体的生理、病理过程,且二者有着多因子、多通路的相互影响,这种错综复杂的关系贯穿于各种心血管疾病的始终,对多种心血管疾病的发生发展转归起重要作用。现对细胞凋亡与自噬及其相互关系进行梳理,并综述其在心血管疾病中的作用。Apoptosis and autophagy are common life phenomenon in various cells, which widely involve in physiological and ...
杨雅瑾, 林小凤, 费燕, 陈尚瑜
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, 2019 肝脏作为体内代谢外源因素暴露最重要的器官之一,具有独特的血窦结构和丰富的免疫细胞亚群,构成了肝脏局部免疫微环境。其中,肝脏的先天免疫细胞既可通过清除病原体、抗原提呈作用参与宿主防御,还通过与肝实质细胞的相互作用参与外源因素介导的急性免疫反应、肝细胞毒性转归、慢性肝损伤以及肝致癌作用。线粒体作为细胞应激的关键靶细胞器,是整合肝脏局部免疫信号的分子互作平台,既通过线粒体质量控制精细调控细胞内的分子事件,也通过线粒体损伤相关分子模式介导不同细胞间通讯和交互作用调控免疫微环境的稳态 ...
张力引, 林忠宁, 林育纯
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